Biosynthesis and Processing of the Cytoadhesins, GPIIb/IIIa and Vitronectin Receptor View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

A. Troesch , A. Duperray , R. Berthier , G. Marguerie

ABSTRACT

Integrins are heterodimers comprised of non covalently associated α and β subunits (1, 2). This family has been divided into four groups of adhesion receptors, according to their β subunit. Each group is composed of glycoproteins sharing the same β subunit and different α subunits. This includes the VLA family (3), the leukocyte adhesion proteins LFA-1, Mac-1 and p 150,95 (4), the cytoadhesin family (5), and the newly identified epithelial integrin (6). The platelet GPIIb/IIIa and the vitronectin receptor (VNR) belong to the cytoadhesin family (5) and share the same β subunit, i.e. GPIIIa or VNRβ (7), according to its primary sequence (8–10) and distinct a subunits, i.e. GPIIb or VNRα (11–13). More... »

PAGES

58-64

References to SciGraph publications

Book

TITLE

Experimental Hematology Today—1989

ISBN

978-1-4613-9005-3
978-1-4613-9003-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-9003-9_10

DOI

http://dx.doi.org/10.1007/978-1-4613-9003-9_10

DIMENSIONS

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