α–Chain Disease: A Possible Model for the Pathogenesis of Human Lymphomas View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1978

AUTHORS

Maxime Seligmann , Jean-Claude Rambaud

ABSTRACT

α–Chain disease (α–CD) is a proliferative disorder of B lymphoid cells involving primarily the IgA secretory system, in which plasma cells produce a presumably homogeneous population of immunoglobulin (Ig) molecules consisting of incomplete α chains devoid of light (L) chains. Since the first description of this new Ig abnormality (Seligmann et al, 1968) in a young Syrian patient affected with malabsorption and diffuse plasmacytic infiltration of the small intestine (Rambaud et al. 1968), more than 150 cases have been recognized to our knowledge. Thus, α–CD appears to be by far the most frequent of the heavy (H)–chain diseases. More... »

PAGES

425-447

References to SciGraph publications

  • 1973-08. Alpha-chain disease in subsaharan Africa in DIGESTIVE DISEASES AND SCIENCES
  • 1975. Structural Variants of Human and Murine Immunoglobulins in CONTEMPORARY TOPICS IN MOLECULAR IMMUNOLOGY
  • 1969-11. Partial Deletion in the Heavy Chain Disease Protein ZUC in NATURE
  • Book

    TITLE

    The Immunopathology of Lymphoreticular Neoplasms

    ISBN

    978-1-4613-4017-1
    978-1-4613-4015-7

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4613-4015-7_14

    DOI

    http://dx.doi.org/10.1007/978-1-4613-4015-7_14

    DIMENSIONS

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    51 schema:description α–Chain disease (α–CD) is a proliferative disorder of B lymphoid cells involving primarily the IgA secretory system, in which plasma cells produce a presumably homogeneous population of immunoglobulin (Ig) molecules consisting of incomplete α chains devoid of light (L) chains. Since the first description of this new Ig abnormality (Seligmann et al, 1968) in a young Syrian patient affected with malabsorption and diffuse plasmacytic infiltration of the small intestine (Rambaud et al. 1968), more than 150 cases have been recognized to our knowledge. Thus, α–CD appears to be by far the most frequent of the heavy (H)–chain diseases.
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