Ecotaxis, Ecotaxopathy, and Lymphoid Malignancy: Terms, Facts, and Predictions View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1978

AUTHORS

Maria De Sousa

ABSTRACT

The term ecotaxis was designed originally to define the capacity of mature cells within the lymphomyeloid system to migrate and arrange themselves in clear-cut microenvironments of the peripheral lymphoid organs (de Sousa, 1971, 1973). Each of the mammalian peripheral lymphoid organs—the spleen, the lymph node, and the Peyer’s patch—can be divided into a number of clearly defined areas that can be represented diagramatically as in Figure 1. The spleen, in addition to containing the lymphoid component originally described by Malpighi (1686) as the follicular white pulp, contains a mixed white- and red-cell component, the red pulp; in the mouse, the red pulp is also a site of hemopoiesis (see Section 1.2.1). The splenic red pulp consists of cords and sinuses that are features of importance for the subsequent fate of circulating cells (see Sections 1.2.2 and 1.2.3). The white pulp, the lymph nodes, and the cortical areas of Peyer’s patches can be divided into thymus-dependent (T) and thymus-independent (B) zones, which contain a predominance of thymus-derived (T) and thymus-independent (B) cells, respectively (Parrott and de Sousa, 1971; de Sousa, 1973; de Sousa and Anderson, 1969). Ultrastructural studies (Veldman, 1970; Hoefschmit, 1974) and studies of the reticulum framework of the spleen and lymph nodes (Veerman, 1974; de Sousa, 1969) have revealed cellular. More... »

PAGES

325-359

Book

TITLE

The Immunopathology of Lymphoreticular Neoplasms

ISBN

978-1-4613-4017-1
978-1-4613-4015-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-4015-7_11

DOI

http://dx.doi.org/10.1007/978-1-4613-4015-7_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003361783


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