A Teratology Test System which Utilizes Postnatal Growth and Viability in the Mouse View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1983

AUTHORS

Neil Chernoff , Robert J. Kavlock

ABSTRACT

The necessity of testing chemical agents for their potential to induce teratogenic effects has led to the establishment of standard teratology protocols (WHO, 1967; Health Protection Branch, 1977). These involve the exposure of pregnant animals to exogenous agents during the period of major embryonic organogenesis and the subsequent examination of the fetuses for soft visceral tissue and skeletal anomalies. These protocols are labor intensive and require highly trained personnel, factors which contribute to the considerable expense of such testing. A variety of potential screens, including developmental anomalies in invertebrates and lower vertebrates (Johnson, 1980; Davis et al., 1981), growth inhibition of mammalian cell cultures (Freese et al., 1979; Wilk et al., 1980), effects on organ culture (Kochar and Aydelotte, 1974), effects on cultured mammalian embryos (Kochar, 1975; Chatot et al., 1980), and in vivo embryotoxicity (Marhan and Jelinek, 1979), have been discussed as possible screens that would allow the prioritization of environmental agents for testing by standard methodologies. There have also been several excellent reviews of this general area in recent years (Wilson, 1978; Barrach and Neubert, 1980). More... »

PAGES

417-427

References to SciGraph publications

  • 1981-05. Toxic and teratogenic effects of selected aromatic amines on embryos of the amphibianXenopus laevis in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 1980-09. Significance of organ culture techniques for evaluation of prenatal toxicity in ARCHIVES OF TOXICOLOGY
  • 1976-06. Fetal toxicity of toxaphene in rats and mice in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • Book

    TITLE

    Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III

    ISBN

    978-1-4613-3613-6
    978-1-4613-3611-2

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4613-3611-2_29

    DOI

    http://dx.doi.org/10.1007/978-1-4613-3611-2_29

    DIMENSIONS

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