Antiphospholipid Antibodies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

G. R. V. Hughes , E. N. Harris , A. E. Gharavi

ABSTRACT

Of the several types of antibodies described in autoimmune disorders, the antiphospholipid antibodies have received relatively little attention. There are two well-described groups of antiphospholipid antibodies, anticardiolipin antibodies (Pangborn, 1941; De Bruijn, 1966; Inoue and Nojima, 1969; Harris et al., 1983, 1985c) and the lupus anticoagulant (Conley and Hartmann, 1952; Margolius et al., 1961; Feinstein and Rapaport, 1972; Veltkamp et al1974; Byron, 1982; Shapiro and Thiagarajan, 1982). Based on the demonstration of cross reactivity of some monoclonal DNA antibodies with cardiolipin and other phospholipids (Lafer et al., 1981; Schoenfeld et al., 1983; Koike et al., 1984a,b), it is believed by some investigators that a subgroup of anti-DNA antibodies may bind to the repeating phosphodiester groups on the polynucleotide backbone of DNA and that these antibodies, too, may be antiphospholipid antibodies. More... »

PAGES

251-269

Book

TITLE

Immunology of Rheumatic Diseases

ISBN

978-1-4612-9509-9
978-1-4613-2493-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-2493-5_10

DOI

http://dx.doi.org/10.1007/978-1-4613-2493-5_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003460240


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