The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ... View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

1985

AUTHORS

C. D. Dijkstra , E. A. Döpp , P. Joling , G. Kraal

ABSTRACT

The precursors of macrophages, originating in the bone marrow, differentiate into circulating monocytes, which, after leaving the peripheral blood for the tissue compartments, differentiate into macrophages. The macrophages form a heterogeneous population, as expressed by differences in their characteristics, like morphology, density, enzyme activity, cell surface properties and functional capacities. Together these characteristics determine the phenotypical appearance of macrophages, which differs with different environmental circumstances, like the state of activity3,6,20,32, the developmental stage of the individual macrophage7, the localization in different tissues12,14,26 and compartments15 and often a combination of these factors. Whether these environmental conditions determine the phenotypical appearance of the macrophages24 or the origin of the heterogeneity is already determined at bone marrow level5 is still a subject of discussion. More... »

PAGES

409-419

Book

TITLE

Microenvironments in the Lymphoid System

ISBN

978-1-4612-9495-5
978-1-4613-2463-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-2463-8_50

DOI

http://dx.doi.org/10.1007/978-1-4613-2463-8_50

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019590164


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