Radioimmunolocalisation of primary cerebral tumours in humans View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

R. B. Richardson , A. G. Davies , S. P. Bourne , G. E. Staddon , D. Jones , J. T. Kemshead , H. B. Coakham

ABSTRACT

Following appropriate animal experiments, radioimmunolocalisation of primary cerebral tumours in 5 patients was performed with a 131I-labelled mouse monoclonal antibody which recognises an antigen expressed by most normal and malignant neuroectodermal tissues. Images were taken at 10 minutes, 4 hours, 24 hours, and thence daily, from the time of injection. Region of Interest Analysis of counts in the tumour and a selected area of normal brain were obtained at each time of scanning. Good tumour localisation was observed in 3 of the 5 patients; in the fourth patient subtraction was needed to demonstrate uptake of the antibody by the tumour, and in the fifth the antibody image remained consistently negative. Regions of interest analysis showed that the radiolabel continued to accumulate in the tumour for between 12 and 24 hours after the time of injection, whereas the counts from the area of normal brain progressively declined with respect to the counts in the 10 minute image. Positive images were present at 4 hours after injection in 2 patients, but optimal times for imaging were between 24 and 120 hours. In one patient studied, the difference in the uptake of a small molecular weight agent, (99m Technetium glucoheptonate) and the antibody conjugate may suggest regional and qualitative Blood Brain Barrier (BBB) breakdown. The BBB may be disrupted to varying degrees in the patients studied, and this should be considered when evaluating scintigraphy of this part of the body. Further studies are in progress to determine the specificity of the uptake of the antibody by the tumour. More... »

PAGES

179-187

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-2297-9_24

DOI

http://dx.doi.org/10.1007/978-1-4613-2297-9_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039626190


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