Spinal Opioid Analgesia: Present Status and Future Developments View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

Perry G. Fine , Theodore H. Stanley

ABSTRACT

Recognition of opiate binding sites (receptors) in the dorsal horn of the spinal cord rapidly led to the demonstration of spinal opioid-mediated analgesia [1–3] and new techniques for delivering pain relief [4–6]. The capability of blocking nociception at discrete spinal cord receptor sites without motor, sensory, or sympathetic blockade is a quantum step forward in pain management. Furthermore, the potential exists for even more precise localization of active receptor sites in the spinal cord, which could dramatically change conventional approaches of administering many times the dose of a drug to effect “equivalent” analgesia. Such changes could eliminate or drastically reduce systemic and other undesirable side effects of oral, parenteral, or spinal analgesia (anesthesia). Thus, spinal opioid analgesia (SOA) may serve as a model for a new principle of anesthetic drug administration that we shall call drug focusing. More... »

PAGES

129-143

References to SciGraph publications

  • 1984-03. Pharmacokinetics of epidural morphine in man in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1971. Polarization Changes Induced in the Pyramidal Cell and Other Neural Elements by Externally Applied Fields in THE NERVOUS SYSTEM AND ELECTRIC CURRENTS
  • Book

    TITLE

    Spinal Narcotics

    ISBN

    978-1-4612-8890-9
    978-1-4613-1609-1

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4613-1609-1_8

    DOI

    http://dx.doi.org/10.1007/978-1-4613-1609-1_8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049794004


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