The β-Globin Dominant Control Region View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

Frank Grosveld , Mike Antoniou , Greet Blom van Assendelft , Phil Collis , Niall Dillon , David R. Greaves , Olivia Hanscombe , Jacky Hurst , Michael Lindenbaum , Dale Talbot , Miguel Vidal

ABSTRACT

The strongest evidence for the existence of an important control in the flanking region of the globin gene domain was provided by the analysis of human γβ-thalassaemias.1,2 Patients with heterozygous Dutch γβ-thalassaemia have a deletion that removes 100 kb of DNA, leaving the β-globin gene and the promoter and enhancer regions intact. However, it abolishes expression of the deleted chromosome and leaves the gene in an inactive chromatin configuration.3–5 The wild-type allele on the other chromosome is expressed at normal levels, indicating that there is no shortage of trans-acting factors. This suggests a cis effect on β-globin gene transcription, which could be caused by a loss of positive acting elements or by the juxtaposition of the intact β-globin gene and sequences that remain in an inactive chromatin configuration in erythroid cells. The first indication that positive acting sites may be involved in activation of the β-globin domain came with the observation of erythroid specific DNasel hypersensitive sites that map 6–18 kb upstream from the ε-globin gene (Fig. 1).6–8 More... »

PAGES

141-148

Book

TITLE

Protein Production by Biotechnology

ISBN

978-1-4612-8858-9
978-1-4613-1565-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-1565-0_10

DOI

http://dx.doi.org/10.1007/978-1-4613-1565-0_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018098741


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grosveld", 
        "givenName": "Frank", 
        "id": "sg:person.010064524477.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010064524477.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antoniou", 
        "givenName": "Mike", 
        "id": "sg:person.014243367454.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014243367454.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Assendelft", 
        "givenName": "Greet Blom", 
        "id": "sg:person.0651604017.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651604017.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collis", 
        "givenName": "Phil", 
        "id": "sg:person.01343606447.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343606447.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dillon", 
        "givenName": "Niall", 
        "id": "sg:person.0675552716.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675552716.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greaves", 
        "givenName": "David R.", 
        "id": "sg:person.01102720407.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102720407.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanscombe", 
        "givenName": "Olivia", 
        "id": "sg:person.01154015246.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154015246.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hurst", 
        "givenName": "Jacky", 
        "id": "sg:person.01052247552.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052247552.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindenbaum", 
        "givenName": "Michael", 
        "id": "sg:person.0644376707.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644376707.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Talbot", 
        "givenName": "Dale", 
        "id": "sg:person.01275473247.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275473247.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vidal", 
        "givenName": "Miguel", 
        "id": "sg:person.013666477457.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013666477457.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0092-8674(83)90103-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004573475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90631-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010045419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.11.3845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017514016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/15.24.10159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018766354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(86)90862-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025842968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/306662a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026221696", 
          "https://doi.org/10.1038/306662a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/283637a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029197826", 
          "https://doi.org/10.1038/283637a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(80)90631-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032443885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(86)90885-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034322384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90630-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034607873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/331035a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036305086", 
          "https://doi.org/10.1038/331035a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(86)90877-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037898644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.82.19.6384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040101303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90584-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041471577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(84)90548-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047716047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/315338a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048403304", 
          "https://doi.org/10.1038/315338a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/338352a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053703271", 
          "https://doi.org/10.1038/338352a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1985.tb03841.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079497531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1988.tb03205.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079613942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081657045", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990", 
    "datePublishedReg": "1990-01-01", 
    "description": "The strongest evidence for the existence of an important control in the flanking region of the globin gene domain was provided by the analysis of human \u03b3\u03b2-thalassaemias.1,2 Patients with heterozygous Dutch \u03b3\u03b2-thalassaemia have a deletion that removes 100 kb of DNA, leaving the \u03b2-globin gene and the promoter and enhancer regions intact. However, it abolishes expression of the deleted chromosome and leaves the gene in an inactive chromatin configuration.3\u20135 The wild-type allele on the other chromosome is expressed at normal levels, indicating that there is no shortage of trans-acting factors. This suggests a cis effect on \u03b2-globin gene transcription, which could be caused by a loss of positive acting elements or by the juxtaposition of the intact \u03b2-globin gene and sequences that remain in an inactive chromatin configuration in erythroid cells. The first indication that positive acting sites may be involved in activation of the \u03b2-globin domain came with the observation of erythroid specific DNasel hypersensitive sites that map 6\u201318 kb upstream from the \u03b5-globin gene (Fig. 1).6\u20138", 
    "editor": [
      {
        "familyName": "Harris", 
        "givenName": "T. J. R.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4613-1565-0_10", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4612-8858-9", 
        "978-1-4613-1565-0"
      ], 
      "name": "Protein Production by Biotechnology", 
      "type": "Book"
    }, 
    "name": "The \u03b2-Globin Dominant Control Region", 
    "pagination": "141-148", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018098741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4613-1565-0_10"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "563bb7eb7b7b52c59be30bcf5c382374ea4176c4243ee6583a96945f68c867e1"
        ]
      }
    ], 
    "publisher": {
      "location": "Boston, MA", 
      "name": "Springer US", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4613-1565-0_10", 
      "https://app.dimensions.ai/details/publication/pub.1018098741"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T09:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130794_00000001.jsonl", 
    "type": "Chapter", 
    "url": "https://link.springer.com/10.1007%2F978-1-4613-1565-0_10"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4613-1565-0_10'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4613-1565-0_10'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4613-1565-0_10'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4613-1565-0_10'


 

This table displays all metadata directly associated to this object as RDF triples.

199 TRIPLES      23 PREDICATES      47 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4613-1565-0_10 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Naefbfef4df3e465a81e501ad12339ad4
4 schema:citation sg:pub.10.1038/283637a0
5 sg:pub.10.1038/306662a0
6 sg:pub.10.1038/315338a0
7 sg:pub.10.1038/331035a0
8 sg:pub.10.1038/338352a0
9 https://app.dimensions.ai/details/publication/pub.1081657045
10 https://doi.org/10.1002/j.1460-2075.1985.tb03841.x
11 https://doi.org/10.1002/j.1460-2075.1988.tb03205.x
12 https://doi.org/10.1016/0092-8674(80)90631-5
13 https://doi.org/10.1016/0092-8674(83)90103-4
14 https://doi.org/10.1016/0092-8674(84)90548-8
15 https://doi.org/10.1016/0092-8674(86)90862-7
16 https://doi.org/10.1016/0092-8674(86)90877-9
17 https://doi.org/10.1016/0092-8674(86)90885-8
18 https://doi.org/10.1016/0092-8674(87)90584-8
19 https://doi.org/10.1016/0092-8674(89)90630-2
20 https://doi.org/10.1016/0092-8674(89)90631-4
21 https://doi.org/10.1073/pnas.82.19.6384
22 https://doi.org/10.1073/pnas.85.11.3845
23 https://doi.org/10.1093/nar/15.24.10159
24 schema:datePublished 1990
25 schema:datePublishedReg 1990-01-01
26 schema:description The strongest evidence for the existence of an important control in the flanking region of the globin gene domain was provided by the analysis of human γβ-thalassaemias.1,2 Patients with heterozygous Dutch γβ-thalassaemia have a deletion that removes 100 kb of DNA, leaving the β-globin gene and the promoter and enhancer regions intact. However, it abolishes expression of the deleted chromosome and leaves the gene in an inactive chromatin configuration.3–5 The wild-type allele on the other chromosome is expressed at normal levels, indicating that there is no shortage of trans-acting factors. This suggests a cis effect on β-globin gene transcription, which could be caused by a loss of positive acting elements or by the juxtaposition of the intact β-globin gene and sequences that remain in an inactive chromatin configuration in erythroid cells. The first indication that positive acting sites may be involved in activation of the β-globin domain came with the observation of erythroid specific DNasel hypersensitive sites that map 6–18 kb upstream from the ε-globin gene (Fig. 1).6–8
27 schema:editor N56e5d6247a8f43b4b3cb90d368a187eb
28 schema:genre chapter
29 schema:inLanguage en
30 schema:isAccessibleForFree false
31 schema:isPartOf Nb22160922b974a7cb088c71a5688860b
32 schema:name The β-Globin Dominant Control Region
33 schema:pagination 141-148
34 schema:productId N562e367083b240ffac4239fb274d4414
35 N666ccde7189641b6b9e86527bd16f521
36 N725eb53281234ad08be61cc7f36edecd
37 schema:publisher Nc7c50bf3e3e346fdbbe670c477ee3c76
38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018098741
39 https://doi.org/10.1007/978-1-4613-1565-0_10
40 schema:sdDatePublished 2019-04-16T09:10
41 schema:sdLicense https://scigraph.springernature.com/explorer/license/
42 schema:sdPublisher N9aed73e46ae046608f49cbf183b3d8fa
43 schema:url https://link.springer.com/10.1007%2F978-1-4613-1565-0_10
44 sgo:license sg:explorer/license/
45 sgo:sdDataset chapters
46 rdf:type schema:Chapter
47 N034fdc91ca534b33ab874a2c9607472a rdf:first sg:person.014243367454.26
48 rdf:rest N0e5e174fd1f2463cae997157ef856242
49 N0e5e174fd1f2463cae997157ef856242 rdf:first sg:person.0651604017.39
50 rdf:rest N84ffbb1c92c1499d932cd1d13768e547
51 N15fd1429a7b241858237844e05cf6c88 rdf:first sg:person.01102720407.51
52 rdf:rest N68b9c103e38e4970a53deffa1b81d6a4
53 N5431896f6b1948bb95a896514fb6f4f5 rdf:first sg:person.01052247552.05
54 rdf:rest Nf7834ab2ceca452a9dda2a47e2c984e1
55 N562e367083b240ffac4239fb274d4414 schema:name dimensions_id
56 schema:value pub.1018098741
57 rdf:type schema:PropertyValue
58 N56e5d6247a8f43b4b3cb90d368a187eb rdf:first N7a386512843d4994b697bc3b6ad8326e
59 rdf:rest rdf:nil
60 N666ccde7189641b6b9e86527bd16f521 schema:name readcube_id
61 schema:value 563bb7eb7b7b52c59be30bcf5c382374ea4176c4243ee6583a96945f68c867e1
62 rdf:type schema:PropertyValue
63 N68b9c103e38e4970a53deffa1b81d6a4 rdf:first sg:person.01154015246.17
64 rdf:rest N5431896f6b1948bb95a896514fb6f4f5
65 N725eb53281234ad08be61cc7f36edecd schema:name doi
66 schema:value 10.1007/978-1-4613-1565-0_10
67 rdf:type schema:PropertyValue
68 N7a386512843d4994b697bc3b6ad8326e schema:familyName Harris
69 schema:givenName T. J. R.
70 rdf:type schema:Person
71 N84ffbb1c92c1499d932cd1d13768e547 rdf:first sg:person.01343606447.05
72 rdf:rest Nb23a0120a2614e748da3ca2c59124419
73 N9aed73e46ae046608f49cbf183b3d8fa schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 Naefbfef4df3e465a81e501ad12339ad4 rdf:first sg:person.010064524477.44
76 rdf:rest N034fdc91ca534b33ab874a2c9607472a
77 Nb22160922b974a7cb088c71a5688860b schema:isbn 978-1-4612-8858-9
78 978-1-4613-1565-0
79 schema:name Protein Production by Biotechnology
80 rdf:type schema:Book
81 Nb23a0120a2614e748da3ca2c59124419 rdf:first sg:person.0675552716.08
82 rdf:rest N15fd1429a7b241858237844e05cf6c88
83 Nc7c50bf3e3e346fdbbe670c477ee3c76 schema:location Boston, MA
84 schema:name Springer US
85 rdf:type schema:Organisation
86 Ne05cc92bf2ee4644986ed9effac9ccd1 rdf:first sg:person.01275473247.63
87 rdf:rest Nf3b76e3d6e4e467db4599e3037c1451f
88 Nf3b76e3d6e4e467db4599e3037c1451f rdf:first sg:person.013666477457.51
89 rdf:rest rdf:nil
90 Nf7834ab2ceca452a9dda2a47e2c984e1 rdf:first sg:person.0644376707.36
91 rdf:rest Ne05cc92bf2ee4644986ed9effac9ccd1
92 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
93 schema:name Biological Sciences
94 rdf:type schema:DefinedTerm
95 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
96 schema:name Genetics
97 rdf:type schema:DefinedTerm
98 sg:person.010064524477.44 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
99 schema:familyName Grosveld
100 schema:givenName Frank
101 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010064524477.44
102 rdf:type schema:Person
103 sg:person.01052247552.05 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
104 schema:familyName Hurst
105 schema:givenName Jacky
106 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052247552.05
107 rdf:type schema:Person
108 sg:person.01102720407.51 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
109 schema:familyName Greaves
110 schema:givenName David R.
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102720407.51
112 rdf:type schema:Person
113 sg:person.01154015246.17 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
114 schema:familyName Hanscombe
115 schema:givenName Olivia
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154015246.17
117 rdf:type schema:Person
118 sg:person.01275473247.63 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
119 schema:familyName Talbot
120 schema:givenName Dale
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275473247.63
122 rdf:type schema:Person
123 sg:person.01343606447.05 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
124 schema:familyName Collis
125 schema:givenName Phil
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343606447.05
127 rdf:type schema:Person
128 sg:person.013666477457.51 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
129 schema:familyName Vidal
130 schema:givenName Miguel
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013666477457.51
132 rdf:type schema:Person
133 sg:person.014243367454.26 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
134 schema:familyName Antoniou
135 schema:givenName Mike
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014243367454.26
137 rdf:type schema:Person
138 sg:person.0644376707.36 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
139 schema:familyName Lindenbaum
140 schema:givenName Michael
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644376707.36
142 rdf:type schema:Person
143 sg:person.0651604017.39 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
144 schema:familyName van Assendelft
145 schema:givenName Greet Blom
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651604017.39
147 rdf:type schema:Person
148 sg:person.0675552716.08 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
149 schema:familyName Dillon
150 schema:givenName Niall
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675552716.08
152 rdf:type schema:Person
153 sg:pub.10.1038/283637a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029197826
154 https://doi.org/10.1038/283637a0
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/306662a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026221696
157 https://doi.org/10.1038/306662a0
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/315338a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048403304
160 https://doi.org/10.1038/315338a0
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/331035a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036305086
163 https://doi.org/10.1038/331035a0
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/338352a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053703271
166 https://doi.org/10.1038/338352a0
167 rdf:type schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1081657045 schema:CreativeWork
169 https://doi.org/10.1002/j.1460-2075.1985.tb03841.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079497531
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1002/j.1460-2075.1988.tb03205.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079613942
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/0092-8674(80)90631-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032443885
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/0092-8674(83)90103-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004573475
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/0092-8674(84)90548-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047716047
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/0092-8674(86)90862-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025842968
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0092-8674(86)90877-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037898644
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/0092-8674(86)90885-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034322384
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/0092-8674(87)90584-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041471577
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/0092-8674(89)90630-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034607873
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/0092-8674(89)90631-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010045419
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1073/pnas.82.19.6384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040101303
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1073/pnas.85.11.3845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017514016
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1093/nar/15.24.10159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018766354
196 rdf:type schema:CreativeWork
197 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
198 schema:name Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK
199 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...