Heterogeneity in Human Acid β-Glucosidase with Cellulose-Acetate Electrophoresis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

M. C. Sa Miranda , R. Pinto , A. W. Schram , J. M. Tager , J. M. F. G. Aerts , J. A. Barranger

ABSTRACT

Human tissues and cells contain multiple isoenzymes of β-glucosidase capable of hydrolyzing 4-methylumbelliferyl-β-glucoside (reviewed in Refs. 1, 2). Besides the lysosomal acid β-glucosidase (glucocerebrosidase, EC 3.2.1.45), a soluble, broad-specificity β-glucosidase and a tightly membrane-bound non-specific β-glucosidase have been described1. Only glucocerebrosidase is able to hydrolyze the lipid glucosylceramide (also called glucocerebroside). Deficiency of glucocerebrosidase is the metabolic basis for Gaucher disease, an inherited lysosomal storage disorder in man2. The other β-glucosidases are not deficient in Gaucher disease1. More... »

PAGES

83-88

Book

TITLE

Lipid Storage Disorders

ISBN

978-1-4612-8300-3
978-1-4613-1029-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-1029-7_9

DOI

http://dx.doi.org/10.1007/978-1-4613-1029-7_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044249015


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute of Health Dr. Ricardo Jorge", 
          "id": "https://www.grid.ac/institutes/grid.422270.1", 
          "name": [
            "Instituto de Genetica Medica, Praca Pedro Nunes 74, 4000\u00a0Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miranda", 
        "givenName": "M. C. Sa", 
        "id": "sg:person.01013406735.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013406735.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Health Dr. Ricardo Jorge", 
          "id": "https://www.grid.ac/institutes/grid.422270.1", 
          "name": [
            "Instituto de Genetica Medica, Praca Pedro Nunes 74, 4000\u00a0Porto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinto", 
        "givenName": "R.", 
        "id": "sg:person.013231326732.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013231326732.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Laboratory of Biochemistry, University of Amsterdam, P.O. Box 20151, 1000 HD\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schram", 
        "givenName": "A. W.", 
        "id": "sg:person.012436416414.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012436416414.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Laboratory of Biochemistry, University of Amsterdam, P.O. Box 20151, 1000 HD\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tager", 
        "givenName": "J. M.", 
        "id": "sg:person.0627746335.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627746335.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Laboratory of Biochemistry, University of Amsterdam, P.O. Box 20151, 1000 HD\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aerts", 
        "givenName": "J. M. F. G.", 
        "id": "sg:person.011356472752.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011356472752.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Division of Medical Genetics, Department of Pediatrics, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA\u00a090054, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barranger", 
        "givenName": "J. A.", 
        "id": "sg:person.013427442463.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013427442463.71"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0005-2736(86)90387-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000462495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(86)90387-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000462495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1987.tb10907.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018422432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2744(80)90235-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020911145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2744(80)90235-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020911145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-9861(85)90609-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035316466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(81)90251-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045329915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(81)90251-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045329915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(85)90276-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048123823"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1988", 
    "datePublishedReg": "1988-01-01", 
    "description": "Human tissues and cells contain multiple isoenzymes of \u03b2-glucosidase capable of hydrolyzing 4-methylumbelliferyl-\u03b2-glucoside (reviewed in Refs. 1, 2). Besides the lysosomal acid \u03b2-glucosidase (glucocerebrosidase, EC 3.2.1.45), a soluble, broad-specificity \u03b2-glucosidase and a tightly membrane-bound non-specific \u03b2-glucosidase have been described1. Only glucocerebrosidase is able to hydrolyze the lipid glucosylceramide (also called glucocerebroside). Deficiency of glucocerebrosidase is the metabolic basis for Gaucher disease, an inherited lysosomal storage disorder in man2. The other \u03b2-glucosidases are not deficient in Gaucher disease1.", 
    "editor": [
      {
        "familyName": "Salvayre", 
        "givenName": "Robert", 
        "type": "Person"
      }, 
      {
        "familyName": "Douste-Blazy", 
        "givenName": "Louis", 
        "type": "Person"
      }, 
      {
        "familyName": "Gatt", 
        "givenName": "Shimon", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4613-1029-7_9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4612-8300-3", 
        "978-1-4613-1029-7"
      ], 
      "name": "Lipid Storage Disorders", 
      "type": "Book"
    }, 
    "name": "Heterogeneity in Human Acid \u03b2-Glucosidase with Cellulose-Acetate Electrophoresis", 
    "pagination": "83-88", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4613-1029-7_9"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d2c5e057988bd95dcaf2d42d1872bae9fd3c2d18dd4649ff9c2be9eba69d0420"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044249015"
        ]
      }
    ], 
    "publisher": {
      "location": "Boston, MA", 
      "name": "Springer US", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4613-1029-7_9", 
      "https://app.dimensions.ai/details/publication/pub.1044249015"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T11:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000270.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-4613-1029-7_9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4613-1029-7_9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4613-1029-7_9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4613-1029-7_9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4613-1029-7_9'


 

This table displays all metadata directly associated to this object as RDF triples.

134 TRIPLES      23 PREDICATES      33 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4613-1029-7_9 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N12cb7b9e880342228fff3b117ce7d00d
4 schema:citation https://doi.org/10.1016/0003-2697(85)90276-3
5 https://doi.org/10.1016/0003-9861(85)90609-5
6 https://doi.org/10.1016/0005-2736(86)90387-1
7 https://doi.org/10.1016/0005-2744(80)90235-1
8 https://doi.org/10.1016/0009-8981(81)90251-5
9 https://doi.org/10.1111/j.1432-1033.1987.tb10907.x
10 schema:datePublished 1988
11 schema:datePublishedReg 1988-01-01
12 schema:description Human tissues and cells contain multiple isoenzymes of β-glucosidase capable of hydrolyzing 4-methylumbelliferyl-β-glucoside (reviewed in Refs. 1, 2). Besides the lysosomal acid β-glucosidase (glucocerebrosidase, EC 3.2.1.45), a soluble, broad-specificity β-glucosidase and a tightly membrane-bound non-specific β-glucosidase have been described1. Only glucocerebrosidase is able to hydrolyze the lipid glucosylceramide (also called glucocerebroside). Deficiency of glucocerebrosidase is the metabolic basis for Gaucher disease, an inherited lysosomal storage disorder in man2. The other β-glucosidases are not deficient in Gaucher disease1.
13 schema:editor Nfdf17f1ea833418699f96d139897bdf6
14 schema:genre chapter
15 schema:inLanguage en
16 schema:isAccessibleForFree false
17 schema:isPartOf Nd1b3025b75034368a6bac8cffbcba9e2
18 schema:name Heterogeneity in Human Acid β-Glucosidase with Cellulose-Acetate Electrophoresis
19 schema:pagination 83-88
20 schema:productId N198b90901a2a4985a05994468a0dad25
21 N1e95caa676594692bdab7a8f0de88f43
22 N4e5a5d847619498782b04b323c0c87bf
23 schema:publisher N9bfe409d42b946d89ac90b96e87bd643
24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044249015
25 https://doi.org/10.1007/978-1-4613-1029-7_9
26 schema:sdDatePublished 2019-04-15T11:37
27 schema:sdLicense https://scigraph.springernature.com/explorer/license/
28 schema:sdPublisher Ne8ea26a74cd34422bfa5dd971955a9d3
29 schema:url http://link.springer.com/10.1007/978-1-4613-1029-7_9
30 sgo:license sg:explorer/license/
31 sgo:sdDataset chapters
32 rdf:type schema:Chapter
33 N12cb7b9e880342228fff3b117ce7d00d rdf:first sg:person.01013406735.08
34 rdf:rest N4d70613b2b094f26914340bc69642b83
35 N198b90901a2a4985a05994468a0dad25 schema:name readcube_id
36 schema:value d2c5e057988bd95dcaf2d42d1872bae9fd3c2d18dd4649ff9c2be9eba69d0420
37 rdf:type schema:PropertyValue
38 N1e95caa676594692bdab7a8f0de88f43 schema:name dimensions_id
39 schema:value pub.1044249015
40 rdf:type schema:PropertyValue
41 N4b734a0708d24ebdb512c0ed0a18217f schema:familyName Gatt
42 schema:givenName Shimon
43 rdf:type schema:Person
44 N4cde4e52e7504419a8833063f4e32c9c schema:familyName Salvayre
45 schema:givenName Robert
46 rdf:type schema:Person
47 N4d70613b2b094f26914340bc69642b83 rdf:first sg:person.013231326732.80
48 rdf:rest N9ee2ee868ad14deea701063f6608f786
49 N4e5a5d847619498782b04b323c0c87bf schema:name doi
50 schema:value 10.1007/978-1-4613-1029-7_9
51 rdf:type schema:PropertyValue
52 N59064ba97889462a9b3189117d18c133 rdf:first sg:person.011356472752.53
53 rdf:rest N803c25d0168944a0be2288e0b2f6df7e
54 N72bee2aa4c994f07afaca23b2c2250d7 rdf:first N4b734a0708d24ebdb512c0ed0a18217f
55 rdf:rest rdf:nil
56 N740a074878ba41e3bddfe42b4d012fe5 rdf:first sg:person.0627746335.85
57 rdf:rest N59064ba97889462a9b3189117d18c133
58 N803c25d0168944a0be2288e0b2f6df7e rdf:first sg:person.013427442463.71
59 rdf:rest rdf:nil
60 N806d02bcf73a4a328a4cc82f0f8a169e rdf:first N9a6e7d8ac35a4a218c1ddf2c6a804119
61 rdf:rest N72bee2aa4c994f07afaca23b2c2250d7
62 N9a6e7d8ac35a4a218c1ddf2c6a804119 schema:familyName Douste-Blazy
63 schema:givenName Louis
64 rdf:type schema:Person
65 N9bfe409d42b946d89ac90b96e87bd643 schema:location Boston, MA
66 schema:name Springer US
67 rdf:type schema:Organisation
68 N9ee2ee868ad14deea701063f6608f786 rdf:first sg:person.012436416414.28
69 rdf:rest N740a074878ba41e3bddfe42b4d012fe5
70 Nd1b3025b75034368a6bac8cffbcba9e2 schema:isbn 978-1-4612-8300-3
71 978-1-4613-1029-7
72 schema:name Lipid Storage Disorders
73 rdf:type schema:Book
74 Ne8ea26a74cd34422bfa5dd971955a9d3 schema:name Springer Nature - SN SciGraph project
75 rdf:type schema:Organization
76 Nfdf17f1ea833418699f96d139897bdf6 rdf:first N4cde4e52e7504419a8833063f4e32c9c
77 rdf:rest N806d02bcf73a4a328a4cc82f0f8a169e
78 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
79 schema:name Biological Sciences
80 rdf:type schema:DefinedTerm
81 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
82 schema:name Biochemistry and Cell Biology
83 rdf:type schema:DefinedTerm
84 sg:person.01013406735.08 schema:affiliation https://www.grid.ac/institutes/grid.422270.1
85 schema:familyName Miranda
86 schema:givenName M. C. Sa
87 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013406735.08
88 rdf:type schema:Person
89 sg:person.011356472752.53 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
90 schema:familyName Aerts
91 schema:givenName J. M. F. G.
92 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011356472752.53
93 rdf:type schema:Person
94 sg:person.012436416414.28 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
95 schema:familyName Schram
96 schema:givenName A. W.
97 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012436416414.28
98 rdf:type schema:Person
99 sg:person.013231326732.80 schema:affiliation https://www.grid.ac/institutes/grid.422270.1
100 schema:familyName Pinto
101 schema:givenName R.
102 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013231326732.80
103 rdf:type schema:Person
104 sg:person.013427442463.71 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
105 schema:familyName Barranger
106 schema:givenName J. A.
107 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013427442463.71
108 rdf:type schema:Person
109 sg:person.0627746335.85 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
110 schema:familyName Tager
111 schema:givenName J. M.
112 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627746335.85
113 rdf:type schema:Person
114 https://doi.org/10.1016/0003-2697(85)90276-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048123823
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1016/0003-9861(85)90609-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035316466
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1016/0005-2736(86)90387-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000462495
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1016/0005-2744(80)90235-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020911145
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1016/0009-8981(81)90251-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045329915
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1111/j.1432-1033.1987.tb10907.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018422432
125 rdf:type schema:CreativeWork
126 https://www.grid.ac/institutes/grid.422270.1 schema:alternateName National Institute of Health Dr. Ricardo Jorge
127 schema:name Instituto de Genetica Medica, Praca Pedro Nunes 74, 4000 Porto, Portugal
128 rdf:type schema:Organization
129 https://www.grid.ac/institutes/grid.42505.36 schema:alternateName University of Southern California
130 schema:name Division of Medical Genetics, Department of Pediatrics, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90054, USA
131 rdf:type schema:Organization
132 https://www.grid.ac/institutes/grid.7177.6 schema:alternateName University of Amsterdam
133 schema:name Laboratory of Biochemistry, University of Amsterdam, P.O. Box 20151, 1000 HD Amsterdam, The Netherlands
134 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...