Identification of the Enzymic Defect in X-Linked Adrenoleukodystrophy: Oxidation of Very Long Chain Fatty Acids is Deficient Due to an ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

R. J. A. Wanders , C. W. T. Van Roermund , M. J. A. Van Wijland , R. B. H. Schutgens , H. Van Den Bosch , A. W. Schram , J. M. Tager

ABSTRACT

Mitochondria were long thought to be the sole site of fatty acid β-oxidation. Following the discovery by Cooper and Beevers1 that castor bean endosperm glyoxysomes, organelles closely related to peroxisomes, contain a fatty acid β-oxidation system, peroxisomes from rat liver2 and various other mammalian tissues were subsequently found to catalyze fatty acyl-CoA β-oxidation as well (reviewed in Refs. 3-6). Like mitochondrial fatty acid β-oxidation, peroxisomal fatty acid β-oxidation proceeds via successive steps of dehydrogenation, hydration, dehydrogenation and thiolytic cleavage. These reactions are catalyzed by the specific peroxisomal β-oxidation enzyme proteins acyl-CoA oxidase (EC 1.3.99.3), the bifunctional protein with enoyl-CoA hydratase (EC 4.2.1.17) and 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) activities and 3-oxoacyl-CoA thiolase (EC 2.3.1.16).7 Despite the apparent similarities in architecture between the β-oxidation systems in peroxisomes and mitochondria, there are a number of important differences between the two systems with regard to the properties of the individual enzymes, cofactor requirements, coupling to energy production etc. Moreover, the peroxisomal and mitochondrial β-oxidation systems have different substrate specificities. Studies by Moser and coworkers for instance have shown that very long chain fatty acids are primarily oxidized in peroxisomes, at least in rat liver.8 That this is also true in man is indicated by the finding of elevated very long chain fatty acid levels in tissues and body fluids from patients suffering from the cerebro-hepato-renal syndrome of Zellweger in which morphologically distinguishable peroxisomes are known to be absent.9 Recent immunoblotting studies have shown that the three peroxisomal β-oxidation enzyme proteins are strongly deficient in liver from Zellweger patients,10-12 which explains the impairment in peroxisomal very long chain fatty acid β-oxidation8,13-16 leading to elevated very long chain fatty acid levels in these patients. More... »

PAGES

405-412

Book

TITLE

Lipid Storage Disorders

ISBN

978-1-4612-8300-3
978-1-4613-1029-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-1029-7_49

DOI

http://dx.doi.org/10.1007/978-1-4613-1029-7_49

DIMENSIONS

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