Autoantibodies Blocking the TSH-Induced Adenylate Cyclase Stimulation in Idiopathic Myxedema and Hashimoto’s Thyroiditis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1987

AUTHORS

P. Vitti , L. Chiovato , A. Lombardi , G. Lopez , F. Santini , P. Ceccarelli , C. Mammoli , L. F. Giusti , S. Battiato , G. F. Fenzi , A. Pinchera

ABSTRACT

Adult idiopathic myxedema (IM) is believed to be the end stage of a lymphocytic thyroiditis in which humoral and cellular autoimmune processes lead to failure of the thyroid function (1). Recent data indicate that this disease may be associated with the presence of autoantibodies which block the effect of TSH on thyroid adenylate cyclase (2, 3) and cell growth (4). In the present report we describe a new method for the detection of blocking autoantibodies (TBkAb) by determining their blocking effect on the TSH-induced thyroid cAMP accumulation in FRTL-5 cells (5, 6). More... »

PAGES

393-395

Book

TITLE

Thyroid Autoimmunity

ISBN

978-1-4612-8258-7
978-1-4613-0945-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-0945-1_63

DOI

http://dx.doi.org/10.1007/978-1-4613-0945-1_63

DIMENSIONS

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