Structure, Function, and Antigenicity of the Hemagglutinin of Influenza Virus View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

S. A. Wharton , W. Weis , J. J. Skehel , D. C. Wiley

ABSTRACT

The major surface glycoprotein of influenza virus is hemagglutinin (HA). This chapter reviews the two major functions of HA: (1) its involvement in binding to receptors on cells before their infection, and (2) its role in the fusion of viral and endosomal membranes, necessary for the release of the viral genome into the cell. In addition, HA is the viral antigen that interacts with infectivity-neutralizing antibodies; alterations in the molecule enable the virus to escape immune surveillance and cause epidemics of disease. The nature of these changes in antigenicity is discussed. More... »

PAGES

153-173

Book

TITLE

The Influenza Viruses

ISBN

978-1-4612-8094-1
978-1-4613-0811-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-0811-9_3

DOI

http://dx.doi.org/10.1007/978-1-4613-0811-9_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006613282


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