The Molecular Basis of HLA—Disease Association View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

J. I. Bell , J. A. Todd , H. O. McDevitt

ABSTRACT

The human major histocompatibility complex (MHC) has been the object of more extensive characterization than any other polymorphic system in man. This complex of loci, situated on the short arm of chromosome 6, has particularly attracted the attention of those interested in the genetic control of immune responsiveness, as these loci are essential components of most humoral and cellular responses. The observation that these loci, which had been defined as several polymorphic series by serology, represented some of the immune response (Ir) genes that had been described in the mouse by McDevitt and Tyan (1968) stimulated further effort to characterize these genes and their products fully and to define further their biological role in the immune response. A further impetus to this work came from the observation that certain MHC alleles were strongly associated with susceptibility to over 40 diseases, mostly autoimmune in nature (Stastny et al., 1983). More... »

PAGES

1-41

References to SciGraph publications

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  • Book

    TITLE

    Advances in Human Genetics

    ISBN

    978-1-4612-8081-1
    978-1-4613-0785-3

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4613-0785-3_1

    DOI

    http://dx.doi.org/10.1007/978-1-4613-0785-3_1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043652260


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