Cryptococcal Meningitis in AIDS Patients A Pilot Study of Fluconazole Therapy in 52 Patients View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

B. Dupont , I. Hilmarsdottir , A. Datry , M. Gentilini , P. Dellamonica , E. Bernard , S. Lefort , J. Frottier , P. Choutet , J. L. Vilde , The French study group on fluconazole in cryptococcal meningitis in AIDS patients

ABSTRACT

Cryptococcal meningitis in AIDS patients is liable to relapse and carries a high mortality rate. Standard treatment with amphotericin B and 5-fluorocytosine is limited by toxic effects. In the present study 64 AIDS patients with cryptococcal meningitis were admitted to a multicentre trial of fluconazole given either orally or intravenously. After a loading dose of 400 mg, two dosage regimens were adopted: 150–200 mg, or 400 mg daily for at least 45–60 days; subsequent maintenance therapy was 100 or 200 mg daily for both groups. Forty seven of the 52 evaluable patients were alive and improved or asymptomatic at day 60 and respectively 7 of 14 and 27 of 31 of those on 200 mg or 400 mg per day had negative cultures of the cerebrospinal fluid. Relapse rate under maintenance therapy was 23%. Fluconazole was well tolerated and free from severe side effects. These results merit further study of fluconazole, either alone or in combination. More... »

PAGES

287-303

Book

TITLE

Mycoses in AIDS Patients

ISBN

978-1-4612-7912-9
978-1-4613-0655-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-0655-9_27

DOI

http://dx.doi.org/10.1007/978-1-4613-0655-9_27

DIMENSIONS

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