Development of Simple and Sensitive System for Detection of Bone Seeking Substances Employing Chick Embryo Tibiae View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

Masaei Kurokawa , Akitoshi Kawakubo , Masahiro Yoneda , Kensuke Takatsuki , Akio Tomita

ABSTRACT

Hypercalcemia is one of the most common complications of malignant diseases. Besides metastatic bone lesions, systemic bone resorption mediated by humoral factors which are produced by tumors causes hypercalcemia. Among many factors attributed to the “humoral hypercalcemia of malignancy”, the adenylate cyclase stimulating factor (ACSF), first described by Stewert et al. (1) in 1980, has been most extensively studied. Recently an ACSF isolated from a lung carcinoma was purified by Martin et al. (2). It is a polypeptide of 18,000 daltons having a remarkable homology with human parathyroid hormone (hPTH). However, ACSFs with different molecular weight have been reported by other investigators, suggesting that there may be multiple ACSF species. More... »

PAGES

451-454

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4613-0567-5_53

DOI

http://dx.doi.org/10.1007/978-1-4613-0567-5_53

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022363078


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