Interactions between protein kinase C and the T3/T cell antigen receptor complex View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

D. A. Cantrell , A. A. Davies , G. Krissansen , M. J. Crumpton

ABSTRACT

Activators of protein kinase C induce T cells to become refractory to mitogenic anti-T3 antibodies. A possible mechanism for this unresponsiveness is suggested by the observations that activation of C kinase results in a rapid down regulation of the surface expression of the T3/T cell antigen receptor complex. As well, there is a concommitant phosphorylation of the T3γ and d polypeptides; the γ chain was more extensively phosphorylated than the d chain. No phosphorylation of the T3e chain and the Ti, α and β polypeptides was detected. Evidence was obtained that the T3γ chain is phosphorylated only on serine residues. More... »

PAGES

119-133

Book

TITLE

Regulation of Immune Gene Expression

ISBN

978-1-4612-9399-6
978-1-4612-5014-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-5014-2_11

DOI

http://dx.doi.org/10.1007/978-1-4612-5014-2_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051792969


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