Glycosphingolipids as Specific Differentiation-Markers and Differentiation-Inducers for Human Myelogenous Leukemia Cells: A Monosialyl Glycosphingolipid, Ganglioside GM3, is Highly Potent for ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

Masaki Saito , Hisao Nojiri , Yasusada Miura

ABSTRACT

Multiple surface-marker analysis recently developed in terms of immunologic, cytogenetic and enzymatic characteristics showed that human acute myelogeous leukemias and their established cell lines were blocked in cell maturation at certain, recognizable differentiation-steps such as myeloblast or promyelocyte stage. Many research-groups including us have demonstrated that some of them could be induced to differentiate into mature functioning cells by various chemical agents, implying the possibility that some leukemic cells are capable of maturation under certain environmental circumstances. This phenomenon gives profound therapeutic importance as well as one of the basic experimental models, providing a clue for elucidating the fundamental mechanisms of regulation for growth and differentiation of hematopoietic cells. More... »

PAGES

64-74

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-4920-7_11

DOI

http://dx.doi.org/10.1007/978-1-4612-4920-7_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020387296


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