Functional Studies with Monoclonal Antibodies Against Function-Associated Leukocyte Antigens View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1986

AUTHORS

Frank Miedema , Fokke G. Terpstra , Cornelius J. M. Melief

ABSTRACT

Lymphocyte function-associated antigen-1 (LFA-1) has initially been described in the mouse system (1,2). Monoclonal antibodies (mAbs) specific for the human counterpart to murine LFA-1 have subsequently been produced in several laboratories (3–6). Anti-LFA-1 mAbs inhibit a variety of T cell functions including cytotoxic T cell (CTL) activity (1–6), natural killer (NK) cell activity (3–6), killer (K) cell activity (6), T cell-dependent immunoglobulin (Ig) synthesis (1), and lectin-induced T cell proliferation (1,2,5). The inhibiting effect of anti-LFA-1 mAbs was shown to be caused by a blockade of cell—cell contact, required for cytotoxic activity (effector—target) or T cell activation (T—macrophage interaction) (2,7). More... »

PAGES

69-76

Book

TITLE

Leukocyte Typing II

ISBN

978-1-4612-9329-3
978-1-4612-4850-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-4850-7_5

DOI

http://dx.doi.org/10.1007/978-1-4612-4850-7_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015836288


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