Chronic HTLV-III Infection in EBV-Genome Containing B-Cell Lines View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1987

AUTHORS

D. V. Ablashi , E. A. Hunter , K. L. Ablashi , S. Z. Salahuddin , P. D. Markham , B. Kramarsky , D. Viza

ABSTRACT

We have shown that B-cell lines lacking the EBV genome could not be infected with HTLV-III regardless of the isolate used. However, upon conversion to EBV positivity these lines could be infected (1). We were interested in obtaining B-cell lines which could continuously support HTLV-III infection similar to T-cell lines and (2) would also produce an infectious virus. Moreover, we wanted to examine the HTLV-III antigen/protein profiles of such cell lines. It is possible that continuous infection of HTLV-III in B-cells may contribute to aberrant humoral responses and/or increased frequency of B-cell malignancies in AIDS patients (3). Two B-cell lines containing the EBV genome were used. LDV-7 an EBV-nonproducer B-cell line (4) after infection with HTLV-III, was designated as DA-1. Another EBV-transformed nonproducer B-cell line (Craig) after HTLV-III infection, was designated as DA-2. For comparison purposes, H-9, a T-cell line, was used (2). More... »

PAGES

457-459

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-4590-2_99

DOI

http://dx.doi.org/10.1007/978-1-4612-4590-2_99

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043119636


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