Studies of Central and “Peripheral-Type” Benzodiazepine Receptors in Autopsied Brain Tissue from Cirrhotic Patients with Hepatic Encephalopathy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

Joël Lavoie , Gilles Pomier Layrargues , Roger F. Butterworth

ABSTRACT

Previous studies with galactosamine-induced liver failure in rats and rabbits suggested that benzodiazepine (BDZ) receptors were modified in brain in hepatic encephalopathy (HE). As part of a series of studies to evaluate brain BDZ receptors in human HE, the integrity of central and “peripheral-type” benzodiazepine receptors was evaluated in brain tissue obtained at autopsy from cirrhotic patients who died with hepatic encephalopathy and an equal number of appropriate controls. Affinities and densities of clonazepam-displaceable binding of [3H]-Flunitrazepam as well as [3H]-Ro15–1788, a specific ligand for central benzodiazepine receptors were unaltered. These findings do not support recent hypothesises that HE results from alterations of the GABA-benzodiazepine receptor complex. On the other hand, increased densities of high affinity binding sites for 3H-PK 11195 were observed in frontal cortex and caudate nuclei of cirrhotic patients with HE. More... »

PAGES

305-318

References to SciGraph publications

Book

TITLE

Hepatic Encephalopathy

ISBN

978-1-4612-8851-0
978-1-4612-4506-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-4506-3_22

DOI

http://dx.doi.org/10.1007/978-1-4612-4506-3_22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043118531


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132 schema:name Lab. of Neurochem. André-Viallet Clin. Res. Centre, Hôpital St-Luc (U. of Montréal), H2X 3J4, Montréal, Québec, Canada
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