TGF-β Inhibition of Intestinal Epithelial Cell Proliferation: G1 Cyclins, Cyclin-Dependent Kinases, and Cyclin Kinase Inhibitors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

E. Aubrey Thompson , Tien C. Ko , R. Daniel Beauchamp

ABSTRACT

Colon carcinogenesis is a multistep process involving alterations in the normal replication of intestinal epithelial cells Vogelstein et al., 1988; Cameron et al., 1990; Vogelstein, 1990. In recent years, there has been a significant increase in our understanding of the basic molecular mechanisms that underlie regulation of cell proliferation. This new insight has provided a clearer picture of gut epithelial cell replication and of the changes that lead to breakdown of these regulatory mechanisms during tumor initiation or progression. Anßsis of gut epithelial cell proliferation also promises to provide fundamental new insight into hormonal inhibition of cell proliferation and into the relationship between hormone insensitivity and transformation. More... »

PAGES

43-71

Book

TITLE

Hormones and Cancer

ISBN

978-1-4612-8715-5
978-1-4612-4266-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-4266-6_2

DOI

http://dx.doi.org/10.1007/978-1-4612-4266-6_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040074246


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