Expression of IGF-I and IGF-I Receptor Gene in the Corpus Luteum View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

T. G. Parmer , M. Zilberstein , I. Khan , C. Albarracin , G. Gibori

ABSTRACT

Insulin-like growth factors (IGFs) are peptide mitogens that have been implicated in growth and development of the rat ovary. Insulin-like growth factor I (IGF-I) has been shown to affect granulosa cell proliferation and differentiation in vitro (1).Recent investigations indicate that granulosa cells produce IGF-I and IGF-I binding proteins (2) and are a major site of IGF-I mRNA gene expression (1). In addition, binding studies have revealed that granulosa and theca interstitial cells have receptors for IGF-I (3).Thus, IGF-I appears to act not only in an autocrine fashion, but also in a paracrine one as well, by serving as one of several signals through which the granulosa cells may communicate with the nearby theca interstitial cells. More... »

PAGES

291-296

References to SciGraph publications

Book

TITLE

Signaling Mechanisms and Gene Expression in the Ovary

ISBN

978-1-4612-7830-6
978-1-4612-3200-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-3200-1_31

DOI

http://dx.doi.org/10.1007/978-1-4612-3200-1_31

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024070740


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