Bioconversion of Fumaric Acid to Succinic Acid by Recombinant E. coli View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

Xiaohai Wang , C. S. Gong , George T. Tsao

ABSTRACT

Succinic acid was produced efficiently from fumaric acid by a recombinant E. coli strain DH5α/pGC1002 containing multicopy fumarate reductase genes. The effects of initial fumaric acid and glucose concentration on the production of succinic acid were investigated. Succinic acid reached 41 to over 60 g/L in 48.5 h starting with 50 to 64 g/L fumaric acid. Significant substrate inhibition was observed at initial fumaric acid concentration of 90 g/L. l-Malic acid became the major fermentation product under these conditions. Provision of glucose (5–30 g/L) to the fermentation medium stimulated the initial succinic acid production rate over two folds. More... »

PAGES

919-928

Book

TITLE

Biotechnology for Fuels and Chemicals

ISBN

978-1-4612-7295-3
978-1-4612-1814-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-1814-2_85

DOI

http://dx.doi.org/10.1007/978-1-4612-1814-2_85

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015612139


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