Production of l-Malic Acid via Biocatalysis Employing Wild-Type and Respiratory-Deficient Yeasts View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

1998

AUTHORS

Xiaohai Wang , C. S. Gong , George T. Tsao

ABSTRACT

The yeast Saccharomyces cerevisiae has been used to efficiently produce l-malic acid from fumaric acid. Fumarase is responsible for the reversible conversion of fumaric and l-malic acids in the TCA cycle. To investigate the function of mitochondrial and cytoplasmic fumarase iso-enzymes in l-malic acid bioconversion, a wild-type strain and a cytoplasmic respiratory-deficient mutant devoid of functional mitochondria were employed. The mutant strain, which only contained the cytoplasmic fumarase, was still functional in fumaric acid to l-malic acid bioconversion. However, its specific conversion rate was much lower (0.20 g/g·h) than that of the wild-type strain (0.55 g/g·h). More... »

PAGES

845-852

References to SciGraph publications

Book

TITLE

Biotechnology for Fuels and Chemicals

ISBN

978-1-4612-7295-3
978-1-4612-1814-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4612-1814-2_77

DOI

http://dx.doi.org/10.1007/978-1-4612-1814-2_77

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034661906


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