Understanding the Benefits of Bariatric Surgery on Gut Physiology: Implications for Obesity, Type 2 Diabetes, and Cardiovascular Disease View Full Text


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Chapter Info

DATE

2015

AUTHORS

Steven K. Malin , John P. Kirwan

ABSTRACT

Seminal discoveries in the bariatric surgery field have revealed a remarkable link between gastrointestinal physiology and obesity, a link that extends to remission of many metabolic diseases including type 2 diabetes and to risk of cardiovascular disease. Much of the beneficial health effects of bariatric surgery can be ascribed to weight loss. However, in the case of type 2 diabetes, resolution is so acute that it appears to be independent of the weight loss. These observations have created the intriguing scenario whereby altering gastrointestinal anatomy creates rapid physiological adaptations that manifest in normalization of glucose homeostasis. The cellular and molecular mechanisms that produce these favorable health changes are an area of intense scientific investigation. One leading hypothesis suggests that rerouting nutrient flow to the gut alters enteroendocrine signals and bile acid secretion that favors appetite suppression; increased energy expenditure and insulin action; and decreased inflammation, blood lipids, and hypertension. In addition, the gut microbiome has emerged as an area of particular interest with a focus on bacteria and metabolites that interact to influence weight regulation and metabolic health. The collective evidence presented herein provides strong support for an essential role for the gastrointestinal tract as a modulator of obesity-related disease. The gut is now considered a novel endocrine organ and a therapeutic target for prevention and treatment strategies that will benefit human health. More... »

PAGES

343-370

References to SciGraph publications

  • 2007-06. Relation of fasting plasma peptide YY to glucose metabolism and cardiovascular risk factors after restrictive bariatric surgery in WIENER KLINISCHE WOCHENSCHRIFT
  • 2010-06. Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype in INTERNATIONAL JOURNAL OF OBESITY
  • 2007-09. Nutritional deficiencies after bariatric surgery in OBESITY SURGERY
  • 2010-03. Acute effects of gastric bypass versus gastric restrictive surgery on β-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes in INTERNATIONAL JOURNAL OF OBESITY
  • 2006-12. Microbial ecology: Human gut microbes associated with obesity in NATURE
  • 2007-11. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia in DIABETOLOGIA
  • 2009-10. Obesity, Gut Hormones, and Bariatric Surgery in WORLD JOURNAL OF SURGERY
  • 2006-01. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation in NATURE
  • 2005-05. Gut microorganisms, mammalian metabolism and personalized health care in NATURE REVIEWS MICROBIOLOGY
  • 2005-11. Is roux-en-y gastric bypass surgery the most effective treatment for type 2 diabetes mellitus in morbidly obese patients? in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2011-04. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease in NATURE
  • 2005-12. U.S. experience with 749 laparoscopic adjustable gastric bands: intermediate outcomes in SURGICAL ENDOSCOPY
  • 2007-02. Long-Term Control of Type 2 Diabetes Mellitus and the Other Major Components of the Metabolic Syndrome after Biliopancreatic Diversion in Patients with BMI <35 kg/m2 in OBESITY SURGERY
  • 2002-04. Malabsorptive gastric bypass in patients with superobesity in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2009-07. Gastric Bypass is not Associated with Protein Malnutrition in Morbidly Obese Patients in OBESITY SURGERY
  • 2005-06. Peripheral Polyneuropathy from Thiamine Deficiency following Laparoscopic Roux-en-Y Gastric Bypass in OBESITY SURGERY
  • 2010-02. Does LKB1 Mediate Activation of Hepatic AMP-Protein Kinase (AMPK) and Sirtuin1 (SIRT1) After Roux-en-Y Gastric Bypass in Obese Rats? in JOURNAL OF GASTROINTESTINAL SURGERY
  • 1998-09. Biliopancreatic Diversion with Duodenal Switch in WORLD JOURNAL OF SURGERY
  • 2008-05-15. Human metabolic phenotype diversity and its association with diet and blood pressure in NATURE
  • 2009-04. Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery in INTERNATIONAL JOURNAL OF OBESITY
  • 2013-12. Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity in INTERNATIONAL JOURNAL OF OBESITY
  • 2010-02. Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus in NATURE REVIEWS ENDOCRINOLOGY
  • 2012-10. The importance of the gut microbiota after bariatric surgery in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2014-05. FXR is a molecular target for the effects of vertical sleeve gastrectomy in NATURE
  • Book

    TITLE

    Metabonomics and Gut Microbiota in Nutrition and Disease

    ISBN

    978-1-4471-6538-5
    978-1-4471-6539-2

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4471-6539-2_16

    DOI

    http://dx.doi.org/10.1007/978-1-4471-6539-2_16

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047316949


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