Pituitary Hormones and the Pathophysiology of Osteoporosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Manasi Agrawal , Shitij Arora , Graziana Colaianni , Li Sun , Jameel Z. Iqbal , Mone Zaidi

ABSTRACT

Pituitary hormones orchestrate the structure and function of various organ systems in the body. A specific, limited function is ascribed to each pituitary hormone. We have come to appreciate that pituitary hormones have profound effects on bone, so much so that the “pituitary-bone axis” is now understood to be integral to skeletal biology. All pituitary hormones play a part in bone regulation, including growth hormone (GH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), prolactin and oxytocin. In mice, reduction in hormone levels due to haploinsufficiency for any one of several pituitary hormones or their receptors alters bone dynamics, while the “primary” target organ remains unaffected. This finding indicates that bone is the more sensitive organ. An in-depth insight into the mechanism of action of each hormone gives us a better understanding of bone pathophysiology and opens up new avenues for treatment of osteoporosis. In this chapter, we discuss the interaction of each pituitary hormone with bone and the potential that targeting these interactions holds in management of osteoporosis. More... »

PAGES

87-100

Book

TITLE

Bone-Metabolic Functions and Modulators

ISBN

978-1-4471-2744-4
978-1-4471-2745-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4471-2745-1_5

DOI

http://dx.doi.org/10.1007/978-1-4471-2745-1_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037792877


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