Pharmacogenetics in Potential Herb–Drug Interactions: Effects of Ginseng on CYP3A4 and CYP2C9 Allelic Variants View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-10-06

AUTHORS

Alice Luu , Brian C. Foster , Kristina L. McIntyre , Teresa W. Tam , John T. Arnason

ABSTRACT

This chapter focuses on the role of ginseng in potential herb–drug interactions through inhibition of cytochrome P450 enzymes CYP3A4 and three polymorphisms of CYP2C9. Using commercial ginseng products and preparations made from authentic ginseng roots, CYP3A4 but not CYP2C9 inhibition correlated significantly with total ginsenoside content of the ginseng products tested. The inhibition of CYP2C9 was low for the three allelic forms and the profile of inhibition by product did not vary with the three polymorphisms tested. These in vitro results suggest that CYP3A4 inhibition, but not CYP2C9 inhibition, may warrant further study in a clinical setting. More... »

PAGES

59-65

References to SciGraph publications

  • 1994-10. Evaluation of the Ergogenic Properties of Ginseng in SPORTS MEDICINE
  • 2005-01. Clinical Consequences of Cytochrome P450 2C9 Polymorphisms in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Book

    TITLE

    The Biological Activity of Phytochemicals

    ISBN

    978-1-4419-6961-3
    978-1-4419-7299-6

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4419-7299-6_5

    DOI

    http://dx.doi.org/10.1007/978-1-4419-7299-6_5

    DIMENSIONS

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