Multi-scale, Multi-physics Heart Simulator as a Tool to Link Bench and Bedside View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2011-07-07

AUTHORS

S. Sugiura , T. Washio , J. Okada , H. Watanabe , T. Hisada

ABSTRACT

Advances in molecular and cell biology have enabled us to identify the genes responsible for the origin of various heart diseases but, in most cases, the detailed mechanisms by which such genetic defects lead to the signs and symptoms observed at the bedside remain to be elucidated. In an attempt to investigate such problems, we have developed a multi-scale, multi-physics heart simulator, in which normal and abnormal functioning of the heart is reproduced based on the molecular mechanisms of the cardiac excitation-contraction (E-C) coupling process. This simulator, based on the finite element method, consists of solid elements representing the myocardium and fluid elements representing the blood in the heart chamber. Each solid element is implemented with a molecular model of E-C coupling and thus behaves as a virtual cardiomyocyte. Because the governing equations for the solid and fluid parts are solved by the strong coupling method, we can obtain detailed information on the blood flow as well as the electrical and mechanical states of every myocyte during the cardiac cycle. Accordingly, this simulator can be used as a tool to see whether any specific molecular abnormality would lead to the development of macroscopic findings, thus making it applicable to various fields of cardiovascular research. More... »

PAGES

253-260

Book

TITLE

Genes and Cardiovascular Function

ISBN

978-1-4419-7206-4
978-1-4419-7207-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4419-7207-1_24

DOI

http://dx.doi.org/10.1007/978-1-4419-7207-1_24

DIMENSIONS

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