Mechanisms of Plasticity of Inhibition in Chronic Pain Conditions View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-10-05

AUTHORS

Charalampos Labrakakis , Francesco Ferrini , Yves De Koninck

ABSTRACT

The balance between inhibition and excitation in the dorsal spinal cord plays a critical role in ensuring that sensory information is relayed accurately to the brain. In particular, a loss of inhibitory control, and the ensuing increase in excitability in spinal dorsal horn neuronal circuits, appears to be a key substrate of pain hypersensitivity. In this Chapter, we summarize the most current knowledge on the involvement of altered GABA and glycine-mediated inhibition in pathological pain. Particular emphasis has been given to the recent finding that altered intracellular chloride homeostasis in neurons of the superficial dorsal horn may explain how inhibition is impaired following peripheral nerve injury and how this may underlie the development of neuropathic pain syndromes. Of particular interest is the finding that this mechanism of injury-induced central disinhibition results from a neuro-immune interaction involving a neuron-to-microglia-to-neuron signalling cascade. More... »

PAGES

91-105

Book

TITLE

Inhibitory Synaptic Plasticity

ISBN

978-1-4419-6977-4
978-1-4419-6978-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4419-6978-1_7

DOI

http://dx.doi.org/10.1007/978-1-4419-6978-1_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044733992


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece", 
          "id": "http://www.grid.ac/institutes/grid.9594.1", 
          "name": [
            "Division Cellular neurobiology, Centre de recherche universit\u00e9 Laval Robert Giffard, Quebec, Canada", 
            "Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Labrakakis", 
        "givenName": "Charalampos", 
        "id": "sg:person.01223405244.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223405244.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ferrini", 
        "givenName": "Francesco", 
        "id": "sg:person.0671222240.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671222240.39"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "De Koninck", 
        "givenName": "Yves", 
        "id": "sg:person.01331376266.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331376266.64"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2010-10-05", 
    "datePublishedReg": "2010-10-05", 
    "description": "The balance between inhibition and excitation in the dorsal spinal cord plays a critical role in ensuring that sensory information is relayed accurately to the brain. In particular, a loss of inhibitory control, and the ensuing increase in excitability in spinal dorsal horn neuronal circuits, appears to be a key substrate of pain hypersensitivity. In this Chapter, we summarize the most current knowledge on the involvement of altered GABA and glycine-mediated inhibition in pathological pain. Particular emphasis has been given to the recent finding that altered intracellular chloride homeostasis in neurons of the superficial dorsal horn may explain how inhibition is impaired following peripheral nerve injury and how this may underlie the development of neuropathic pain syndromes. Of particular interest is the finding that this mechanism of injury-induced central disinhibition results from a neuro-immune interaction involving a neuron-to-microglia-to-neuron signalling cascade.", 
    "editor": [
      {
        "familyName": "Woodin", 
        "givenName": "Melanie A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Maffei", 
        "givenName": "Arianna", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4419-6978-1_7", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4419-6977-4", 
        "978-1-4419-6978-1"
      ], 
      "name": "Inhibitory Synaptic Plasticity", 
      "type": "Book"
    }, 
    "keywords": [
      "neuro-immune interactions", 
      "neuropathic pain syndromes", 
      "superficial dorsal horn", 
      "peripheral nerve injury", 
      "chronic pain conditions", 
      "dorsal spinal cord", 
      "intracellular chloride homeostasis", 
      "pain hypersensitivity", 
      "pathological pain", 
      "pain syndrome", 
      "dorsal horn", 
      "nerve injury", 
      "pain conditions", 
      "spinal cord", 
      "mechanisms of plasticity", 
      "chloride homeostasis", 
      "neuronal circuits", 
      "inhibitory control", 
      "neurons", 
      "inhibition", 
      "sensory information", 
      "recent findings", 
      "current knowledge", 
      "critical role", 
      "pain", 
      "microglia", 
      "cord", 
      "syndrome", 
      "findings", 
      "injury", 
      "excitability", 
      "GABA", 
      "hypersensitivity", 
      "brain", 
      "key substrate", 
      "homeostasis", 
      "horn", 
      "involvement", 
      "mechanism", 
      "control", 
      "plasticity", 
      "particular emphasis", 
      "role", 
      "increase", 
      "cascade", 
      "loss", 
      "glycine", 
      "particular interest", 
      "development", 
      "balance", 
      "knowledge", 
      "results", 
      "emphasis", 
      "information", 
      "conditions", 
      "interaction", 
      "interest", 
      "chapter", 
      "circuit", 
      "substrate", 
      "excitation", 
      "spinal dorsal horn neuronal circuits", 
      "dorsal horn neuronal circuits", 
      "horn neuronal circuits", 
      "injury-induced central disinhibition results", 
      "central disinhibition results", 
      "disinhibition results"
    ], 
    "name": "Mechanisms of Plasticity of Inhibition in Chronic Pain Conditions", 
    "pagination": "91-105", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044733992"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4419-6978-1_7"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4419-6978-1_7", 
      "https://app.dimensions.ai/details/publication/pub.1044733992"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2021-12-01T20:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/chapter/chapter_368.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4419-6978-1_7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4419-6978-1_7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4419-6978-1_7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4419-6978-1_7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4419-6978-1_7'


 

This table displays all metadata directly associated to this object as RDF triples.

145 TRIPLES      23 PREDICATES      91 URIs      84 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4419-6978-1_7 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nb32949fe7e7c44a4bd9ab26beb5ac6ca
4 schema:datePublished 2010-10-05
5 schema:datePublishedReg 2010-10-05
6 schema:description The balance between inhibition and excitation in the dorsal spinal cord plays a critical role in ensuring that sensory information is relayed accurately to the brain. In particular, a loss of inhibitory control, and the ensuing increase in excitability in spinal dorsal horn neuronal circuits, appears to be a key substrate of pain hypersensitivity. In this Chapter, we summarize the most current knowledge on the involvement of altered GABA and glycine-mediated inhibition in pathological pain. Particular emphasis has been given to the recent finding that altered intracellular chloride homeostasis in neurons of the superficial dorsal horn may explain how inhibition is impaired following peripheral nerve injury and how this may underlie the development of neuropathic pain syndromes. Of particular interest is the finding that this mechanism of injury-induced central disinhibition results from a neuro-immune interaction involving a neuron-to-microglia-to-neuron signalling cascade.
7 schema:editor Na7a55590159346989538fbdadbe67262
8 schema:genre chapter
9 schema:inLanguage en
10 schema:isAccessibleForFree false
11 schema:isPartOf N491d9ac612144222a4dd75048569dab4
12 schema:keywords GABA
13 balance
14 brain
15 cascade
16 central disinhibition results
17 chapter
18 chloride homeostasis
19 chronic pain conditions
20 circuit
21 conditions
22 control
23 cord
24 critical role
25 current knowledge
26 development
27 disinhibition results
28 dorsal horn
29 dorsal horn neuronal circuits
30 dorsal spinal cord
31 emphasis
32 excitability
33 excitation
34 findings
35 glycine
36 homeostasis
37 horn
38 horn neuronal circuits
39 hypersensitivity
40 increase
41 information
42 inhibition
43 inhibitory control
44 injury
45 injury-induced central disinhibition results
46 interaction
47 interest
48 intracellular chloride homeostasis
49 involvement
50 key substrate
51 knowledge
52 loss
53 mechanism
54 mechanisms of plasticity
55 microglia
56 nerve injury
57 neuro-immune interactions
58 neuronal circuits
59 neurons
60 neuropathic pain syndromes
61 pain
62 pain conditions
63 pain hypersensitivity
64 pain syndrome
65 particular emphasis
66 particular interest
67 pathological pain
68 peripheral nerve injury
69 plasticity
70 recent findings
71 results
72 role
73 sensory information
74 spinal cord
75 spinal dorsal horn neuronal circuits
76 substrate
77 superficial dorsal horn
78 syndrome
79 schema:name Mechanisms of Plasticity of Inhibition in Chronic Pain Conditions
80 schema:pagination 91-105
81 schema:productId N8abc7f67bad9416092cc398744660431
82 Nfe82c520380b43759fa46ba2a21ec8f5
83 schema:publisher N250e418f23474956b7d83968f86fae77
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044733992
85 https://doi.org/10.1007/978-1-4419-6978-1_7
86 schema:sdDatePublished 2021-12-01T20:07
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N857a6b41e2154efcb280a26c8cf6a48a
89 schema:url https://doi.org/10.1007/978-1-4419-6978-1_7
90 sgo:license sg:explorer/license/
91 sgo:sdDataset chapters
92 rdf:type schema:Chapter
93 N250e418f23474956b7d83968f86fae77 schema:name Springer Nature
94 rdf:type schema:Organisation
95 N491d9ac612144222a4dd75048569dab4 schema:isbn 978-1-4419-6977-4
96 978-1-4419-6978-1
97 schema:name Inhibitory Synaptic Plasticity
98 rdf:type schema:Book
99 N53351dd6332d42ef9df9bdb59c6f3d5a schema:familyName Maffei
100 schema:givenName Arianna
101 rdf:type schema:Person
102 N69d30c59157d4a89860d964f5bfc492c schema:familyName Woodin
103 schema:givenName Melanie A.
104 rdf:type schema:Person
105 N857a6b41e2154efcb280a26c8cf6a48a schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 N8abc7f67bad9416092cc398744660431 schema:name dimensions_id
108 schema:value pub.1044733992
109 rdf:type schema:PropertyValue
110 N9856ebf13bae4c249c0c82600477555e rdf:first sg:person.0671222240.39
111 rdf:rest Na96d50faa3d24f98815239ddff12f6a9
112 Na7a55590159346989538fbdadbe67262 rdf:first N69d30c59157d4a89860d964f5bfc492c
113 rdf:rest Nba678a7e7c224181b7071b66f1086509
114 Na96d50faa3d24f98815239ddff12f6a9 rdf:first sg:person.01331376266.64
115 rdf:rest rdf:nil
116 Nb32949fe7e7c44a4bd9ab26beb5ac6ca rdf:first sg:person.01223405244.25
117 rdf:rest N9856ebf13bae4c249c0c82600477555e
118 Nba678a7e7c224181b7071b66f1086509 rdf:first N53351dd6332d42ef9df9bdb59c6f3d5a
119 rdf:rest rdf:nil
120 Nfe82c520380b43759fa46ba2a21ec8f5 schema:name doi
121 schema:value 10.1007/978-1-4419-6978-1_7
122 rdf:type schema:PropertyValue
123 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
124 schema:name Medical and Health Sciences
125 rdf:type schema:DefinedTerm
126 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
127 schema:name Neurosciences
128 rdf:type schema:DefinedTerm
129 sg:person.01223405244.25 schema:affiliation grid-institutes:grid.9594.1
130 schema:familyName Labrakakis
131 schema:givenName Charalampos
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223405244.25
133 rdf:type schema:Person
134 sg:person.01331376266.64 schema:familyName De Koninck
135 schema:givenName Yves
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331376266.64
137 rdf:type schema:Person
138 sg:person.0671222240.39 schema:familyName Ferrini
139 schema:givenName Francesco
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671222240.39
141 rdf:type schema:Person
142 grid-institutes:grid.9594.1 schema:alternateName Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece
143 schema:name Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece
144 Division Cellular neurobiology, Centre de recherche université Laval Robert Giffard, Quebec, Canada
145 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...