Gene Therapy for Sarcoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-06-26

AUTHORS

Keila E. Torres , Raphael E. Pollock

ABSTRACT

Soft tissue sarcomas are a group of potentially devastating malignancies. Despite multidisciplinary treatment combining surgery, radiation therapy, and chemotherapy, the overall prognosis for sarcoma patients remains poor. Very few chemotherapeutic agents with meaningful efficacy: toxicity ratios are available, and the development of novel therapeutics will be critical if this currently unacceptable prognosis is to be improved. Much exciting progress in genetic profiling of sarcomas and molecular identification of constituent oncogenes and protein products has recently occurred, which will ultimately enable the development of sarcoma targeted therapies. In this chapter, we discuss the major advances in cytogenetics and the importance of genetic and molecular signatures in sarcoma diagnosis and treatment. In an attempt to create better treatments for cancers several strategies have evolved to administer therapeutic genes that inactivate oncogenes, restore tumor-suppressor genes, and enhance the native immune response. We explore some promising initial data regarding novel gene delivery systems, such as isolated limb perfusion which may be a useful promising technique in delivering growth-suppressing constructs into soft tissue sarcomas. More... »

PAGES

251-268

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  • Book

    TITLE

    Gene-Based Therapies for Cancer

    ISBN

    978-1-4419-6101-3
    978-1-4419-6102-0

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4419-6102-0_14

    DOI

    http://dx.doi.org/10.1007/978-1-4419-6102-0_14

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045581693


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