Translational Medicine—A Paradigm Shift in Modern Drug Discovery and Development: The Role of Biomarkers View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Mark Day , J. Lynn Rutkowski , Giora Z. Feuerstein

ABSTRACT

The success rate of novel medical entities that are submitted for registration by the regulatory agencies and followed successful marketing has been stagnating for the past decade. Failure in efficacy and safety continue to be the prime hurdles and causes of failure. Translational medicine is a new function within the pharmaceutical industry R&D organization aimed to improve the predictability and success of drug discovery and development. Biomarkers are the essence of the translational medicine strategy focus on disease biomarker, patient selection, pharmacodynamic responses (efficacy and safety) target validation, compound-target interaction). Successful deployment of biomarkers research, validation and implementation is adopted and embraced as key strategy to improved the drug discovery and development towards new medical entities. More... »

PAGES

1-12

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4419-1132-2_1

DOI

http://dx.doi.org/10.1007/978-1-4419-1132-2_1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013394269

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20047030


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemistry, Pharmaceutical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Discovery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmaceutical Preparations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Design", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Wyeth Research, 500 Arcola Road, COL S2307, 19426, Collegeville, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Day", 
        "givenName": "Mark", 
        "id": "sg:person.01073532626.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073532626.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Wyeth Research, 500 Arcola Road, COL S2307, 19426, Collegeville, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rutkowski", 
        "givenName": "J. Lynn", 
        "id": "sg:person.0755414256.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755414256.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Wyeth Research, 500 Arcola Road, COL S2307, 19426, Collegeville, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feuerstein", 
        "givenName": "Giora Z.", 
        "id": "sg:person.01317467302.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317467302.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrd2251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002728270", 
          "https://doi.org/10.1038/nrd2251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ddstr.2005.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004078647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2007.05.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004730274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.298.1.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006877932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.npp.1300710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011392563", 
          "https://doi.org/10.1038/sj.npp.1300710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.npp.1300710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011392563", 
          "https://doi.org/10.1038/sj.npp.1300710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6446(05)03721-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017763031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.61.4.354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017901399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018773545", 
          "https://doi.org/10.1038/nrd1927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018773545", 
          "https://doi.org/10.1038/nrd1927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10543400600614742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021089706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmp058315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026883810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-07-0255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028510342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0009-9236(97)90160-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031926675", 
          "https://doi.org/10.1016/s0009-9236(97)90160-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1067/mcp.2001.113989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032912526", 
          "https://doi.org/10.1067/mcp.2001.113989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1789.2007.00798.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036050303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000092527.33910.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036182363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000092527.33910.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036182363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.1006e12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072204857"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009", 
    "datePublishedReg": "2009-01-01", 
    "description": "The success rate of novel medical entities that are submitted for registration by the regulatory agencies and followed successful marketing has been stagnating for the past decade. Failure in efficacy and safety continue to be the prime hurdles and causes of failure. Translational medicine is a new function within the pharmaceutical industry R&D organization aimed to improve the predictability and success of drug discovery and development. Biomarkers are the essence of the translational medicine strategy focus on disease biomarker, patient selection, pharmacodynamic responses (efficacy and safety) target validation, compound-target interaction). Successful deployment of biomarkers research, validation and implementation is adopted and embraced as key strategy to improved the drug discovery and development towards new medical entities.", 
    "editor": [
      {
        "familyName": "Guzm\u00e1n", 
        "givenName": "Carlos A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Feuerstein", 
        "givenName": "Giora Z.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4419-1132-2_1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4419-1131-5", 
        "978-1-4419-1132-2"
      ], 
      "name": "Pharmaceutical Biotechnology", 
      "type": "Book"
    }, 
    "name": "Translational Medicine\u2014A Paradigm Shift in Modern Drug Discovery and Development: The Role of Biomarkers", 
    "pagination": "1-12", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20047030"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013394269"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4419-1132-2_1"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3fcf04378fe3246e2449ca598cc68892848d2bf804d430a1cd246741ab7f4b0a"
        ]
      }
    ], 
    "publisher": {
      "location": "New York, NY", 
      "name": "Springer New York", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4419-1132-2_1", 
      "https://app.dimensions.ai/details/publication/pub.1013394269"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T07:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000356_0000000356/records_57865_00000000.jsonl", 
    "type": "Chapter", 
    "url": "https://link.springer.com/10.1007%2F978-1-4419-1132-2_1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4419-1132-2_1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4419-1132-2_1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4419-1132-2_1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4419-1132-2_1'


 

This table displays all metadata directly associated to this object as RDF triples.

173 TRIPLES      23 PREDICATES      52 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4419-1132-2_1 schema:about N146f903c49764d9b94016ac8dc369a30
2 N4a33835def954892b225822151f945d9
3 N6b07c0939bed4b479702a5855f460801
4 N6c4f95105e6d4b608139e979019d9588
5 N9f2eee1c9e0e4313acd970590c87a318
6 Nc2e4dcbc6f6d42fd848393d68145e052
7 Ncb1f8a61361546f3aeed7d90a89447ba
8 Ne5bc5b59db3a4501a51a46cb974b9cdd
9 anzsrc-for:11
10 anzsrc-for:1115
11 schema:author N7cb0e0231d40469582971f32208d2ea7
12 schema:citation sg:pub.10.1016/s0009-9236(97)90160-0
13 sg:pub.10.1038/nrd1927
14 sg:pub.10.1038/nrd2251
15 sg:pub.10.1038/sj.npp.1300710
16 sg:pub.10.1067/mcp.2001.113989
17 https://doi.org/10.1001/archpsyc.61.4.354
18 https://doi.org/10.1001/jama.298.1.29
19 https://doi.org/10.1016/j.ddstr.2005.08.010
20 https://doi.org/10.1016/j.schres.2007.05.039
21 https://doi.org/10.1016/s1359-6446(05)03721-9
22 https://doi.org/10.1056/nejmp058315
23 https://doi.org/10.1080/10543400600614742
24 https://doi.org/10.1111/j.1440-1789.2007.00798.x
25 https://doi.org/10.1158/1535-7163.mct-07-0255
26 https://doi.org/10.1161/01.str.0000092527.33910.89
27 https://doi.org/10.4088/jcp.1006e12
28 schema:datePublished 2009
29 schema:datePublishedReg 2009-01-01
30 schema:description The success rate of novel medical entities that are submitted for registration by the regulatory agencies and followed successful marketing has been stagnating for the past decade. Failure in efficacy and safety continue to be the prime hurdles and causes of failure. Translational medicine is a new function within the pharmaceutical industry R&D organization aimed to improve the predictability and success of drug discovery and development. Biomarkers are the essence of the translational medicine strategy focus on disease biomarker, patient selection, pharmacodynamic responses (efficacy and safety) target validation, compound-target interaction). Successful deployment of biomarkers research, validation and implementation is adopted and embraced as key strategy to improved the drug discovery and development towards new medical entities.
31 schema:editor Nd9bf2f1527b74c10a91c534391a6583e
32 schema:genre chapter
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N7896feb6dd3b4a65bf6d54f286bebefa
36 schema:name Translational Medicine—A Paradigm Shift in Modern Drug Discovery and Development: The Role of Biomarkers
37 schema:pagination 1-12
38 schema:productId N3c5b99fcc75a491db43a1a26bddadedd
39 N6cf74474a01c4a9eb7c16d316d02606e
40 Nd9c84f5211104f51b8d482ca9945897e
41 Nf668973a9ef54065b438548884433e60
42 schema:publisher Nd92deca4d9114e3f82206ea028d9edd5
43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013394269
44 https://doi.org/10.1007/978-1-4419-1132-2_1
45 schema:sdDatePublished 2019-04-16T07:29
46 schema:sdLicense https://scigraph.springernature.com/explorer/license/
47 schema:sdPublisher N8dc851c38b7b45f7875aa37640cac648
48 schema:url https://link.springer.com/10.1007%2F978-1-4419-1132-2_1
49 sgo:license sg:explorer/license/
50 sgo:sdDataset chapters
51 rdf:type schema:Chapter
52 N11a32adf5ba44a69a2ccafa9018bcb2a schema:familyName Feuerstein
53 schema:givenName Giora Z.
54 rdf:type schema:Person
55 N146f903c49764d9b94016ac8dc369a30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Clinical Trials as Topic
57 rdf:type schema:DefinedTerm
58 N1981ad7e51b54cc1bcd91f1f66929fc9 rdf:first N11a32adf5ba44a69a2ccafa9018bcb2a
59 rdf:rest rdf:nil
60 N2c12af7da4024850a1274ed2c898f94f rdf:first sg:person.0755414256.10
61 rdf:rest Ne78e4ab3e93e44fbb62f6a7df2e11913
62 N3c5b99fcc75a491db43a1a26bddadedd schema:name pubmed_id
63 schema:value 20047030
64 rdf:type schema:PropertyValue
65 N4a33835def954892b225822151f945d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Biomarkers
67 rdf:type schema:DefinedTerm
68 N6b07c0939bed4b479702a5855f460801 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Humans
70 rdf:type schema:DefinedTerm
71 N6c4f95105e6d4b608139e979019d9588 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Drug Design
73 rdf:type schema:DefinedTerm
74 N6cf74474a01c4a9eb7c16d316d02606e schema:name doi
75 schema:value 10.1007/978-1-4419-1132-2_1
76 rdf:type schema:PropertyValue
77 N7896feb6dd3b4a65bf6d54f286bebefa schema:isbn 978-1-4419-1131-5
78 978-1-4419-1132-2
79 schema:name Pharmaceutical Biotechnology
80 rdf:type schema:Book
81 N7cb0e0231d40469582971f32208d2ea7 rdf:first sg:person.01073532626.96
82 rdf:rest N2c12af7da4024850a1274ed2c898f94f
83 N8dc851c38b7b45f7875aa37640cac648 schema:name Springer Nature - SN SciGraph project
84 rdf:type schema:Organization
85 N9f2eee1c9e0e4313acd970590c87a318 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Drug Discovery
87 rdf:type schema:DefinedTerm
88 Nc2e4dcbc6f6d42fd848393d68145e052 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Pharmaceutical Preparations
90 rdf:type schema:DefinedTerm
91 Ncb1f8a61361546f3aeed7d90a89447ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Chemistry, Pharmaceutical
93 rdf:type schema:DefinedTerm
94 Nd92deca4d9114e3f82206ea028d9edd5 schema:location New York, NY
95 schema:name Springer New York
96 rdf:type schema:Organisation
97 Nd9bf2f1527b74c10a91c534391a6583e rdf:first Nf2a6cbbd473d442d886db7babdf327a1
98 rdf:rest N1981ad7e51b54cc1bcd91f1f66929fc9
99 Nd9c84f5211104f51b8d482ca9945897e schema:name dimensions_id
100 schema:value pub.1013394269
101 rdf:type schema:PropertyValue
102 Ne5bc5b59db3a4501a51a46cb974b9cdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Research Design
104 rdf:type schema:DefinedTerm
105 Ne78e4ab3e93e44fbb62f6a7df2e11913 rdf:first sg:person.01317467302.28
106 rdf:rest rdf:nil
107 Nf2a6cbbd473d442d886db7babdf327a1 schema:familyName Guzmán
108 schema:givenName Carlos A.
109 rdf:type schema:Person
110 Nf668973a9ef54065b438548884433e60 schema:name readcube_id
111 schema:value 3fcf04378fe3246e2449ca598cc68892848d2bf804d430a1cd246741ab7f4b0a
112 rdf:type schema:PropertyValue
113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
114 schema:name Medical and Health Sciences
115 rdf:type schema:DefinedTerm
116 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
117 schema:name Pharmacology and Pharmaceutical Sciences
118 rdf:type schema:DefinedTerm
119 sg:person.01073532626.96 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
120 schema:familyName Day
121 schema:givenName Mark
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073532626.96
123 rdf:type schema:Person
124 sg:person.01317467302.28 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
125 schema:familyName Feuerstein
126 schema:givenName Giora Z.
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317467302.28
128 rdf:type schema:Person
129 sg:person.0755414256.10 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
130 schema:familyName Rutkowski
131 schema:givenName J. Lynn
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755414256.10
133 rdf:type schema:Person
134 sg:pub.10.1016/s0009-9236(97)90160-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031926675
135 https://doi.org/10.1016/s0009-9236(97)90160-0
136 rdf:type schema:CreativeWork
137 sg:pub.10.1038/nrd1927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018773545
138 https://doi.org/10.1038/nrd1927
139 rdf:type schema:CreativeWork
140 sg:pub.10.1038/nrd2251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002728270
141 https://doi.org/10.1038/nrd2251
142 rdf:type schema:CreativeWork
143 sg:pub.10.1038/sj.npp.1300710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011392563
144 https://doi.org/10.1038/sj.npp.1300710
145 rdf:type schema:CreativeWork
146 sg:pub.10.1067/mcp.2001.113989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032912526
147 https://doi.org/10.1067/mcp.2001.113989
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1001/archpsyc.61.4.354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017901399
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1001/jama.298.1.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006877932
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/j.ddstr.2005.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004078647
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/j.schres.2007.05.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004730274
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/s1359-6446(05)03721-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017763031
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1056/nejmp058315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026883810
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1080/10543400600614742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021089706
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1111/j.1440-1789.2007.00798.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036050303
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1158/1535-7163.mct-07-0255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028510342
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1161/01.str.0000092527.33910.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036182363
168 rdf:type schema:CreativeWork
169 https://doi.org/10.4088/jcp.1006e12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072204857
170 rdf:type schema:CreativeWork
171 https://www.grid.ac/institutes/grid.410513.2 schema:alternateName Pfizer (United States)
172 schema:name Wyeth Research, 500 Arcola Road, COL S2307, 19426, Collegeville, Pennsylvania, USA
173 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...