Poorly Differentiated Colorectal Adenocarcinoma (Methodology) View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Seiichi Shinji , Zenya Naito , Toshiyuki Ishiwata , Matsuda Yoko , Tomoko Seya , Takashi Tajiri

ABSTRACT

Poorly differentiated adenocarcinoma (PDAC) constitutes ∼ 2–25% of all colorec-tal carcinomas (CRCs) (Riddle et al., 2003; Ueno et al., 2002). In Japan, the frequency of PDAC among CRCs has been reported to be>5%, whereas it is between 10–25% in Western countries (Taniyama et al., 1991). Clinically, PDAC often penetrates deep through the bowel wall and frequ ently metastasizes to the lymph nodes or distant organs. PDAC is characterized by local recurrences and/or distant metastases despite curative surgery, and its prognosis is poor compared to well- or moderately-differentiated colorectal adenocarcinoma (Chung et al., 1982).Some PDACs show neuroendocrine cell differentiation in the part of the tumor. Neuroendocrine cell differentiation occurs in about 15% of PDAC patients (Shinji et al., 2006). The frequency of liver metas tasis at the time of diagnosis is significantly higher in PDAC patients with neuroendo-crine cell differentiation than in those without neuroendocrine cell differentiation. The microvessel density and vascular endothelial growth factor-A (VEGF-A) expression level tend to be high in PDAC patients with neuroendocrine cell differ entiation, and PDAC with neuroendocrine cell differentiation might induce liver metastasis through microvessel formation in the tumor as induced by VEGF-A. In the near future, the regulation of VEGF-A expression in PDAC patients with or with out neuroendocrine cell differentiation might become a new molecular target for the inhibition of liver metastasis and tumor regression. More... »

PAGES

13-23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4020-9545-0_2

DOI

http://dx.doi.org/10.1007/978-1-4020-9545-0_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005908477


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