Response of Nerve Cell to Inhibitor Recorded by Aluminium-Gallium-Nitride FET View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Michael Gebinoga , Irina Cimalla , Liele Silveira , Maren Klett , Vadim Lebedev , Florentina Niebelschütz , Oliver Ambacher , Andreas Schober

ABSTRACT

In this work we report on the recording of extracellular potential of NG108-15 nerve cells as response to diisopropylfluorophosphate (DFP) using an open gate aluminium gallium nitride/gallium nitride (AlGaN/GaN) field effect transistor. The biocompatibility study of our GaN materials with NG108-15 nerve cells shows a proliferation rate of about 95%. The DFP was added to the medium with and without adherent cells and we record the source-drain current (IDS) of the AlGaN/GaN field effect transistor versus time. The cells react very differently to the inhibitor in the case of repeated titrations of the DFP inhibitor. A saturation concentration was determined, above which no further cell reaction was detectable. Sensor reaction without cells exhibits a clearly distinguishable behavior. More... »

PAGES

311-318

References to SciGraph publications

Book

TITLE

Sensors for Environment, Health and Security

ISBN

978-1-4020-9010-3
978-1-4020-9009-7

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4020-9009-7_20

DOI

http://dx.doi.org/10.1007/978-1-4020-9009-7_20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030546434


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