Cell Transplantation Therapy for Myocardial Repair: Current Status and Future Challenges View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Wangde Dai , Robert A. Kloner

ABSTRACT

Recent experimental studies and clinical trials have demonstrated that cell transplantation therapy has the potential to improve cardiac function after myocardial infarction. However, the mechanisms responsible for the observed therapeutic effects remain unknown. Different mechanisms have been proposed to explain the beneficial effects, including regeneration of contractile myocardial tissue, therapeutic neovascularization, prevention of left ventricular remodeling, release of paracrine growth factors, induction of nerve fiber regeneration, and potential influences on the cardiac stem cell niche. Furthermore, the clinical application of stem cell transplantation therapy still faces many challenges, such as tumor formation and unexpected differentiation, immunogenicity, arrhythmogenesis of engrafted stem cells, as well as how to prevent cell loss after transplantation. In this chapter, we review the current status of cell transplantation therapy, and discuss future challenges for its application in treating ischemic heart disease. More... »

PAGES

193-212

Book

TITLE

Stem Cell Research and Therapeutics

ISBN

978-1-4020-8501-7
978-1-4020-8502-4

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4020-8502-4_11

DOI

http://dx.doi.org/10.1007/978-1-4020-8502-4_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042885199


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