Utilization of Plant Metabolic Engineering for Production of Pharmaceuticals in Tea View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

A. Borthakur , R. K. Dutta , S. Borchetia , Sudripta Das

ABSTRACT

Plant biotechnology combined with genetic engineering have contributed immensely to the development of and increase in the medicinal value of plants. The proven medicinal properties of tea include antioxidative, anti-tumourous, antiallergic, antibacterial, antiviral and antiseptic properties. The present study is on the application of molecular studies to identify and overcome rate-limiting steps in accumulation of secondary metabolites involved in the catechin and terpenoid pathways for production of choice chemicals in tea. The construction of cDNA library, identification, cloning and overexpression of genes related to the catechin and terpenoid pathways in tea are discussed. An increase in the secondary metabolite content in cell suspension cultures of tea was observed in the presence of signal molecules which culminated in the effort to understand the mechanism of regulation of the pathways. For the first time genes from the carotenoid pathway (four) and monoterpenes (two) were cloned from tea. The analysis of modified tea plants containing multiple copies of the various genes cloned would help to better understand the measurements of flux coefficients, metabolite channeling and the interactions between enzymes and other protein partners. The identification of the transcriptors and regulators related to the catechin and terpenoid pathways would help in better manipulation of these pathways for improvement of quality. More... »

PAGES

235-258

Book

TITLE

Biotechnology and Sustainable Agriculture 2006 and Beyond

ISBN

978-1-4020-6634-4
978-1-4020-6635-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4020-6635-1_38

DOI

http://dx.doi.org/10.1007/978-1-4020-6635-1_38

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047998227


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