Site-Directed Homologous Recombination in Tobacco Cell Cultures via Zinc Finger Nucleases View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Charles Q. Cai , W. Michael Ainley , Trevor N. Collingwood , Robbi J. Garrison , Lisa L. Schulenberg , Andrew Worden , Philip D. Gregory , Beth C. Rubin-Wilson , Joseph F. Petolino

ABSTRACT

Targeted transgene integration via homologous recombination occurs at a very low frequency in plant cells compared to random integration, even when the incoming DNA comprises large stretches of sequence homologous to host DNA. As such, gene targeting in plants via homologous recombination has not been practical. Most recently, substantial increases in the frequency of homologous recombination have been observed following the induction of DNA double stranded breaks in host cells and apparent stimulation of cellular repair mechanisms. Restriction enzymes whose recognition sites are rare in the plant genome have been shown to stimulate homologous recombination following the formation and repair of DNA double stranded breaks in the host DNA. Strategies to achieve targeted DNA double stranded breaks have been developed by fusing zinc finger DNA binding proteins with sequence-independent nuclease domains derived from Type II restriction endonucleases More... »

PAGES

111-113

Book

TITLE

Biotechnology and Sustainable Agriculture 2006 and Beyond

ISBN

978-1-4020-6634-4
978-1-4020-6635-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4020-6635-1_12

DOI

http://dx.doi.org/10.1007/978-1-4020-6635-1_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026220227


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA", 
          "id": "http://www.grid.ac/institutes/grid.418574.b", 
          "name": [
            "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cai", 
        "givenName": "Charles Q.", 
        "id": "sg:person.0777575546.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777575546.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA", 
          "id": "http://www.grid.ac/institutes/grid.418574.b", 
          "name": [
            "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ainley", 
        "givenName": "W. Michael", 
        "id": "sg:person.0667056024.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667056024.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sangamo BioSciences, Inc., 501 Canal Blvd, 94804, Richmond, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.421831.d", 
          "name": [
            "Sangamo BioSciences, Inc., 501 Canal Blvd, 94804, Richmond, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collingwood", 
        "givenName": "Trevor N.", 
        "id": "sg:person.01042227251.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042227251.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA", 
          "id": "http://www.grid.ac/institutes/grid.418574.b", 
          "name": [
            "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garrison", 
        "givenName": "Robbi J.", 
        "id": "sg:person.01350342246.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350342246.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA", 
          "id": "http://www.grid.ac/institutes/grid.418574.b", 
          "name": [
            "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schulenberg", 
        "givenName": "Lisa L.", 
        "id": "sg:person.0673051346.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673051346.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA", 
          "id": "http://www.grid.ac/institutes/grid.418574.b", 
          "name": [
            "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Worden", 
        "givenName": "Andrew", 
        "id": "sg:person.0671245221.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671245221.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sangamo BioSciences, Inc., 501 Canal Blvd, 94804, Richmond, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.421831.d", 
          "name": [
            "Sangamo BioSciences, Inc., 501 Canal Blvd, 94804, Richmond, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gregory", 
        "givenName": "Philip D.", 
        "id": "sg:person.015620210017.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015620210017.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA", 
          "id": "http://www.grid.ac/institutes/grid.418574.b", 
          "name": [
            "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rubin-Wilson", 
        "givenName": "Beth C.", 
        "id": "sg:person.01117351540.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117351540.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA", 
          "id": "http://www.grid.ac/institutes/grid.418574.b", 
          "name": [
            "Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petolino", 
        "givenName": "Joseph F.", 
        "id": "sg:person.01253462235.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253462235.19"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2007", 
    "datePublishedReg": "2007-01-01", 
    "description": "Targeted transgene integration via homologous recombination occurs at a very low frequency in plant cells compared to random integration, even when the incoming DNA comprises large stretches of sequence homologous to host DNA. As such, gene targeting in plants via homologous recombination has not been practical. Most recently, substantial increases in the frequency of homologous recombination have been observed following the induction of DNA double stranded breaks in host cells and apparent stimulation of cellular repair mechanisms. Restriction enzymes whose recognition sites are rare in the plant genome have been shown to stimulate homologous recombination following the formation and repair of DNA double stranded breaks in the host DNA. Strategies to achieve targeted DNA double stranded breaks have been developed by fusing zinc finger DNA binding proteins with sequence-independent nuclease domains derived from Type II restriction endonucleases", 
    "editor": [
      {
        "familyName": "Xu", 
        "givenName": "Zhihong", 
        "type": "Person"
      }, 
      {
        "familyName": "Li", 
        "givenName": "Jiayang", 
        "type": "Person"
      }, 
      {
        "familyName": "Xue", 
        "givenName": "Yongbiao", 
        "type": "Person"
      }, 
      {
        "familyName": "Yang", 
        "givenName": "Weicai", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4020-6635-1_12", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4020-6634-4", 
        "978-1-4020-6635-1"
      ], 
      "name": "Biotechnology and Sustainable Agriculture 2006 and Beyond", 
      "type": "Book"
    }, 
    "keywords": [
      "homologous recombination", 
      "zinc finger DNA", 
      "zinc finger nucleases", 
      "tobacco cell cultures", 
      "repair of DNA", 
      "type II restriction", 
      "cellular repair mechanisms", 
      "plant genomes", 
      "induction of DNA", 
      "plant cells", 
      "nuclease domain", 
      "finger nucleases", 
      "random integration", 
      "incoming DNA", 
      "transgene integration", 
      "host DNA", 
      "host cells", 
      "repair mechanisms", 
      "DNA", 
      "recognition sites", 
      "large stretches", 
      "recombination", 
      "apparent stimulation", 
      "cell cultures", 
      "genome", 
      "cells", 
      "genes", 
      "nuclease", 
      "breaks", 
      "plants", 
      "protein", 
      "sites", 
      "sequence", 
      "induction", 
      "stretch", 
      "domain", 
      "substantial increase", 
      "mechanism", 
      "repair", 
      "culture", 
      "stimulation", 
      "formation", 
      "low frequency", 
      "strategies", 
      "integration", 
      "increase", 
      "restriction", 
      "frequency"
    ], 
    "name": "Site-Directed Homologous Recombination in Tobacco Cell Cultures via Zinc Finger Nucleases", 
    "pagination": "111-113", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026220227"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4020-6635-1_12"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4020-6635-1_12", 
      "https://app.dimensions.ai/details/publication/pub.1026220227"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-09-02T16:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/chapter/chapter_430.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4020-6635-1_12"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4020-6635-1_12'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4020-6635-1_12'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4020-6635-1_12'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4020-6635-1_12'


 

This table displays all metadata directly associated to this object as RDF triples.

181 TRIPLES      22 PREDICATES      73 URIs      66 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4020-6635-1_12 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Ncfe907a0b0ae45aaba477d3794f959fc
4 schema:datePublished 2007
5 schema:datePublishedReg 2007-01-01
6 schema:description Targeted transgene integration via homologous recombination occurs at a very low frequency in plant cells compared to random integration, even when the incoming DNA comprises large stretches of sequence homologous to host DNA. As such, gene targeting in plants via homologous recombination has not been practical. Most recently, substantial increases in the frequency of homologous recombination have been observed following the induction of DNA double stranded breaks in host cells and apparent stimulation of cellular repair mechanisms. Restriction enzymes whose recognition sites are rare in the plant genome have been shown to stimulate homologous recombination following the formation and repair of DNA double stranded breaks in the host DNA. Strategies to achieve targeted DNA double stranded breaks have been developed by fusing zinc finger DNA binding proteins with sequence-independent nuclease domains derived from Type II restriction endonucleases
7 schema:editor N246258c637d2411f950abf9c7ca61c08
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf Nd632d383e62d447d90fd31cf923808ad
11 schema:keywords DNA
12 apparent stimulation
13 breaks
14 cell cultures
15 cells
16 cellular repair mechanisms
17 culture
18 domain
19 finger nucleases
20 formation
21 frequency
22 genes
23 genome
24 homologous recombination
25 host DNA
26 host cells
27 incoming DNA
28 increase
29 induction
30 induction of DNA
31 integration
32 large stretches
33 low frequency
34 mechanism
35 nuclease
36 nuclease domain
37 plant cells
38 plant genomes
39 plants
40 protein
41 random integration
42 recognition sites
43 recombination
44 repair
45 repair mechanisms
46 repair of DNA
47 restriction
48 sequence
49 sites
50 stimulation
51 strategies
52 stretch
53 substantial increase
54 tobacco cell cultures
55 transgene integration
56 type II restriction
57 zinc finger DNA
58 zinc finger nucleases
59 schema:name Site-Directed Homologous Recombination in Tobacco Cell Cultures via Zinc Finger Nucleases
60 schema:pagination 111-113
61 schema:productId N2f1beda78adf427e8870226a39286be3
62 N84e714b680cc4b88bb55fada156a81fb
63 schema:publisher N9eb2a7e3a72e440fae5499a062490ba2
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026220227
65 https://doi.org/10.1007/978-1-4020-6635-1_12
66 schema:sdDatePublished 2022-09-02T16:16
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N30801ac0309c449fbe05e6be25efc04b
69 schema:url https://doi.org/10.1007/978-1-4020-6635-1_12
70 sgo:license sg:explorer/license/
71 sgo:sdDataset chapters
72 rdf:type schema:Chapter
73 N246258c637d2411f950abf9c7ca61c08 rdf:first Na38cf39c3c444559b816e600a5c75ddd
74 rdf:rest N6653f5d2ca18426b8415b3361a1567a9
75 N2f1beda78adf427e8870226a39286be3 schema:name doi
76 schema:value 10.1007/978-1-4020-6635-1_12
77 rdf:type schema:PropertyValue
78 N30801ac0309c449fbe05e6be25efc04b schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 N54301ae28df145f7b72011a3d74b0b59 schema:familyName Li
81 schema:givenName Jiayang
82 rdf:type schema:Person
83 N6653f5d2ca18426b8415b3361a1567a9 rdf:first N54301ae28df145f7b72011a3d74b0b59
84 rdf:rest Ne464951b220c4de8a6b744a3869ebb71
85 N6efc207d82a843afbb8884be56c800f7 rdf:first Nba455e10d9b140508fef58dca241ce44
86 rdf:rest rdf:nil
87 N6f29c92005be4b47a55f4144cf0b43e1 rdf:first sg:person.01042227251.89
88 rdf:rest Nf386554c88744a7d8e3bd92ff5779209
89 N84a9a974e67c4a4aafe4f98836ae515c rdf:first sg:person.01117351540.02
90 rdf:rest Nb9181c527ded413bbfb1f62b02651ebe
91 N84e714b680cc4b88bb55fada156a81fb schema:name dimensions_id
92 schema:value pub.1026220227
93 rdf:type schema:PropertyValue
94 N86b8915cdee341dca9a59670bdb0d191 rdf:first sg:person.015620210017.02
95 rdf:rest N84a9a974e67c4a4aafe4f98836ae515c
96 N9eb2a7e3a72e440fae5499a062490ba2 schema:name Springer Nature
97 rdf:type schema:Organisation
98 Na38cf39c3c444559b816e600a5c75ddd schema:familyName Xu
99 schema:givenName Zhihong
100 rdf:type schema:Person
101 Nac00592412e0494ca6264d37ddf399cd rdf:first sg:person.0671245221.13
102 rdf:rest N86b8915cdee341dca9a59670bdb0d191
103 Nb9181c527ded413bbfb1f62b02651ebe rdf:first sg:person.01253462235.19
104 rdf:rest rdf:nil
105 Nba455e10d9b140508fef58dca241ce44 schema:familyName Yang
106 schema:givenName Weicai
107 rdf:type schema:Person
108 Nbe8e2f181ed541abba585e0c4da6221c rdf:first sg:person.0673051346.30
109 rdf:rest Nac00592412e0494ca6264d37ddf399cd
110 Ncc8bf32452a349cfa64905cf27aa92cb schema:familyName Xue
111 schema:givenName Yongbiao
112 rdf:type schema:Person
113 Ncfe907a0b0ae45aaba477d3794f959fc rdf:first sg:person.0777575546.30
114 rdf:rest Nee4efa2bd0ad4b4d8612a654d7699b18
115 Nd632d383e62d447d90fd31cf923808ad schema:isbn 978-1-4020-6634-4
116 978-1-4020-6635-1
117 schema:name Biotechnology and Sustainable Agriculture 2006 and Beyond
118 rdf:type schema:Book
119 Ne464951b220c4de8a6b744a3869ebb71 rdf:first Ncc8bf32452a349cfa64905cf27aa92cb
120 rdf:rest N6efc207d82a843afbb8884be56c800f7
121 Nee4efa2bd0ad4b4d8612a654d7699b18 rdf:first sg:person.0667056024.14
122 rdf:rest N6f29c92005be4b47a55f4144cf0b43e1
123 Nf386554c88744a7d8e3bd92ff5779209 rdf:first sg:person.01350342246.24
124 rdf:rest Nbe8e2f181ed541abba585e0c4da6221c
125 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
126 schema:name Biological Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
129 schema:name Genetics
130 rdf:type schema:DefinedTerm
131 sg:person.01042227251.89 schema:affiliation grid-institutes:grid.421831.d
132 schema:familyName Collingwood
133 schema:givenName Trevor N.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042227251.89
135 rdf:type schema:Person
136 sg:person.01117351540.02 schema:affiliation grid-institutes:grid.418574.b
137 schema:familyName Rubin-Wilson
138 schema:givenName Beth C.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117351540.02
140 rdf:type schema:Person
141 sg:person.01253462235.19 schema:affiliation grid-institutes:grid.418574.b
142 schema:familyName Petolino
143 schema:givenName Joseph F.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253462235.19
145 rdf:type schema:Person
146 sg:person.01350342246.24 schema:affiliation grid-institutes:grid.418574.b
147 schema:familyName Garrison
148 schema:givenName Robbi J.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350342246.24
150 rdf:type schema:Person
151 sg:person.015620210017.02 schema:affiliation grid-institutes:grid.421831.d
152 schema:familyName Gregory
153 schema:givenName Philip D.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015620210017.02
155 rdf:type schema:Person
156 sg:person.0667056024.14 schema:affiliation grid-institutes:grid.418574.b
157 schema:familyName Ainley
158 schema:givenName W. Michael
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667056024.14
160 rdf:type schema:Person
161 sg:person.0671245221.13 schema:affiliation grid-institutes:grid.418574.b
162 schema:familyName Worden
163 schema:givenName Andrew
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671245221.13
165 rdf:type schema:Person
166 sg:person.0673051346.30 schema:affiliation grid-institutes:grid.418574.b
167 schema:familyName Schulenberg
168 schema:givenName Lisa L.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673051346.30
170 rdf:type schema:Person
171 sg:person.0777575546.30 schema:affiliation grid-institutes:grid.418574.b
172 schema:familyName Cai
173 schema:givenName Charles Q.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777575546.30
175 rdf:type schema:Person
176 grid-institutes:grid.418574.b schema:alternateName Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA
177 schema:name Dow AgroSciences, LLC, 9330 Zionsville Rd, 46268, Indianapolis, IN, USA
178 rdf:type schema:Organization
179 grid-institutes:grid.421831.d schema:alternateName Sangamo BioSciences, Inc., 501 Canal Blvd, 94804, Richmond, CA, USA
180 schema:name Sangamo BioSciences, Inc., 501 Canal Blvd, 94804, Richmond, CA, USA
181 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...