Pharmacology of calcium currents in mammalian central neurones View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1984

AUTHORS

D. A. Brown , A. Constanti , R. J. Docherty , M. Galvan , B. Gähwiler , J. V. Halliwell

ABSTRACT

A variety of neurones possess Ca-currents (ICa (Hagiwara & Byerly, 1981; Kostyuk, 1981). Mammalian central neurones are no exception: the presence of Ca-currents has been inferred from a variety of Ca-dependent voltage transients (reviewed by Llinas & Walton, 1980), and has been verified directly by voltage-clamp experiments in spinal motoneurones (Schwindt & Crill, 1980a,b) and hippocampal pyramidal cells (Johnston et al., 1980; Brown & Griffith, 1983b). In addition to their role (at terminals) in transmitter release, these currents play an important part in determining the electrical behaviour of brain cells (see Llinas & Walton, 1980; Crill & Schwindt, 1983). Notwithstanding, information about the properties of ICa in central neurones — and particularly their sensitivity to pharmacological agents — is comparatively rudimentary when compared with that available for the equivalent currents in cardiac cells or in invertebrate neurones (see Reuter, 1983). More... »

PAGES

343-348

Book

TITLE

IUPHAR 9th International Congress of Pharmacology

ISBN

978-0-333-37135-0
978-1-349-86029-6

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-349-86029-6_45

DOI

http://dx.doi.org/10.1007/978-1-349-86029-6_45

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086286583


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