Use of Rabbit Models to Study Atherosclerosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2022-03-02

AUTHORS

Jianglin Fan , Manabu Niimi , Yajie Chen , Ritsuko Suzuki , Enqi Liu

ABSTRACT

Rabbits are a useful animal model for examining human hyperlipidemia and atherosclerosis because they have unique features of lipoprotein metabolism that are similar to those in humans. Feeding rabbits a cholesterol-rich diet is a simple means to induce experimental atherosclerosis. Indeed, cholesterol-fed rabbits were first applied to address the relationship between dietary cholesterol and atherosclerosis more than 100 years ago. However, the methods for investigating atherosclerosis using cholesterol-fed rabbits have not been well formulated. In this chapter, we attempt to provide readers with the essential methods to use cholesterol-fed rabbits in the examination of atherosclerosis from cholesterol diet preparation to lesion analysis. These protocols are compiled for both experienced and young researchers who intend to use rabbits for the investigation of lipoprotein metabolism and atherosclerosis. More... »

PAGES

413-431

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-0716-1924-7_25

DOI

http://dx.doi.org/10.1007/978-1-0716-1924-7_25

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1145981065

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35237979


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0399", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atherosclerosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, Dietary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypercholesterolemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China", 
          "id": "http://www.grid.ac/institutes/grid.500400.1", 
          "name": [
            "Department of Molecular Pathology, Faculty of Medicine, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Japan", 
            "School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fan", 
        "givenName": "Jianglin", 
        "id": "sg:person.01136672602.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136672602.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Pathology, Faculty of Medicine, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Molecular Pathology, Faculty of Medicine, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niimi", 
        "givenName": "Manabu", 
        "id": "sg:person.01115327172.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115327172.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China", 
          "id": "http://www.grid.ac/institutes/grid.500400.1", 
          "name": [
            "Department of Molecular Pathology, Faculty of Medicine, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Japan", 
            "School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yajie", 
        "id": "sg:person.01037035370.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037035370.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Admission Center, University of Yamanashi, Kofu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Admission Center, University of Yamanashi, Kofu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Ritsuko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute of Atherosclerotic Disease and Laboratory Animal Center, Xi\u2019an Jiaotong University School of Medicine, Xi\u2019an, China", 
          "id": "http://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Research Institute of Atherosclerotic Disease and Laboratory Animal Center, Xi\u2019an Jiaotong University School of Medicine, Xi\u2019an, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Enqi", 
        "id": "sg:person.016446245112.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016446245112.43"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2022-03-02", 
    "datePublishedReg": "2022-03-02", 
    "description": "Rabbits are a useful animal model for examining human hyperlipidemia and atherosclerosis because they have unique features of lipoprotein metabolism that are similar to those in humans. Feeding rabbits a cholesterol-rich diet is a simple means to induce experimental atherosclerosis. Indeed, cholesterol-fed rabbits were first applied to address the relationship between dietary cholesterol and atherosclerosis more than 100\u00a0years ago. However, the methods for investigating atherosclerosis using cholesterol-fed rabbits have not been well formulated. In this chapter, we attempt to provide readers with the essential methods to use cholesterol-fed rabbits in the examination of atherosclerosis from cholesterol diet preparation to lesion analysis. These protocols are compiled for both experienced and young researchers who intend to use rabbits for the investigation of lipoprotein metabolism and atherosclerosis.", 
    "editor": [
      {
        "familyName": "Ramji", 
        "givenName": "Dipak", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-0716-1924-7_25", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-0716-1923-0", 
        "978-1-0716-1924-7"
      ], 
      "name": "Atherosclerosis", 
      "type": "Book"
    }, 
    "keywords": [
      "cholesterol-fed rabbits", 
      "lipoprotein metabolism", 
      "cholesterol-rich diet", 
      "useful animal model", 
      "experimental atherosclerosis", 
      "dietary cholesterol", 
      "atherosclerosis", 
      "animal models", 
      "human hyperlipidemia", 
      "rabbit model", 
      "rabbits", 
      "diet preparation", 
      "metabolism", 
      "hyperlipidemia", 
      "cholesterol", 
      "diet", 
      "examination", 
      "humans", 
      "years", 
      "protocol", 
      "use", 
      "unique features", 
      "essential method", 
      "simple means", 
      "relationship", 
      "investigation", 
      "method", 
      "preparation", 
      "analysis", 
      "features", 
      "model", 
      "means", 
      "chapter", 
      "researchers", 
      "readers", 
      "young researchers"
    ], 
    "name": "Use of Rabbit Models to Study Atherosclerosis", 
    "pagination": "413-431", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1145981065"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-0716-1924-7_25"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35237979"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-0716-1924-7_25", 
      "https://app.dimensions.ai/details/publication/pub.1145981065"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-09-02T16:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/chapter/chapter_40.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-0716-1924-7_25"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-0716-1924-7_25'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-0716-1924-7_25'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-0716-1924-7_25'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-0716-1924-7_25'


 

This table displays all metadata directly associated to this object as RDF triples.

171 TRIPLES      22 PREDICATES      69 URIs      60 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-0716-1924-7_25 schema:about N2d9bfe69ec9b4250be2cf0790f7ac963
2 N4d3c9a818da34b4cb4b6d574ec14f5d0
3 N5cd449eb70a04e689ac3adf40f0e5d25
4 N7ee0245bea254218be47f3f3c8762fed
5 N944aa621e32948f282f5739f0b590994
6 Na0ceebe8f6164bd5a0590c0bffdc6086
7 Nff61463f07b843edb68965a69db4ebe4
8 anzsrc-for:03
9 anzsrc-for:0399
10 anzsrc-for:06
11 anzsrc-for:0601
12 schema:author N10ed91089aaa4adc9628d83c4effa8d3
13 schema:datePublished 2022-03-02
14 schema:datePublishedReg 2022-03-02
15 schema:description Rabbits are a useful animal model for examining human hyperlipidemia and atherosclerosis because they have unique features of lipoprotein metabolism that are similar to those in humans. Feeding rabbits a cholesterol-rich diet is a simple means to induce experimental atherosclerosis. Indeed, cholesterol-fed rabbits were first applied to address the relationship between dietary cholesterol and atherosclerosis more than 100 years ago. However, the methods for investigating atherosclerosis using cholesterol-fed rabbits have not been well formulated. In this chapter, we attempt to provide readers with the essential methods to use cholesterol-fed rabbits in the examination of atherosclerosis from cholesterol diet preparation to lesion analysis. These protocols are compiled for both experienced and young researchers who intend to use rabbits for the investigation of lipoprotein metabolism and atherosclerosis.
16 schema:editor N50de57a3753a42f0aa3fbd8a4a72068d
17 schema:genre chapter
18 schema:isAccessibleForFree false
19 schema:isPartOf Nd1c9f75fc1c54025b8c6f7b67c927018
20 schema:keywords analysis
21 animal models
22 atherosclerosis
23 chapter
24 cholesterol
25 cholesterol-fed rabbits
26 cholesterol-rich diet
27 diet
28 diet preparation
29 dietary cholesterol
30 essential method
31 examination
32 experimental atherosclerosis
33 features
34 human hyperlipidemia
35 humans
36 hyperlipidemia
37 investigation
38 lipoprotein metabolism
39 means
40 metabolism
41 method
42 model
43 preparation
44 protocol
45 rabbit model
46 rabbits
47 readers
48 relationship
49 researchers
50 simple means
51 unique features
52 use
53 useful animal model
54 years
55 young researchers
56 schema:name Use of Rabbit Models to Study Atherosclerosis
57 schema:pagination 413-431
58 schema:productId N39414b5920ac4230af51d37a27867f7b
59 N5311c7305e1e4b8fa5d131bc6a875073
60 Nc1b87248eb2047a0bb9c7a6d0195c606
61 schema:publisher N4dc568b4992b41d7b31043460f127c1c
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1145981065
63 https://doi.org/10.1007/978-1-0716-1924-7_25
64 schema:sdDatePublished 2022-09-02T16:15
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N2a370ae9d9084ee2a94763afd728b518
67 schema:url https://doi.org/10.1007/978-1-0716-1924-7_25
68 sgo:license sg:explorer/license/
69 sgo:sdDataset chapters
70 rdf:type schema:Chapter
71 N00168f0ac25545c9bcac3438f72ef5bd rdf:first sg:person.01115327172.22
72 rdf:rest N90ae85284f4046ac8bebec6cadf383a5
73 N10ed91089aaa4adc9628d83c4effa8d3 rdf:first sg:person.01136672602.49
74 rdf:rest N00168f0ac25545c9bcac3438f72ef5bd
75 N2a370ae9d9084ee2a94763afd728b518 schema:name Springer Nature - SN SciGraph project
76 rdf:type schema:Organization
77 N2d9bfe69ec9b4250be2cf0790f7ac963 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Hypercholesterolemia
79 rdf:type schema:DefinedTerm
80 N2fee79883224463c9b7535e241d5c243 rdf:first N5c219c5ceb444c18a865a803035a219f
81 rdf:rest N48742d7332814296ae469ed4f8936ef7
82 N39414b5920ac4230af51d37a27867f7b schema:name doi
83 schema:value 10.1007/978-1-0716-1924-7_25
84 rdf:type schema:PropertyValue
85 N431f14b1b93d4828a08761d3d88df57d schema:familyName Ramji
86 schema:givenName Dipak
87 rdf:type schema:Person
88 N48742d7332814296ae469ed4f8936ef7 rdf:first sg:person.016446245112.43
89 rdf:rest rdf:nil
90 N4d3c9a818da34b4cb4b6d574ec14f5d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Animals
92 rdf:type schema:DefinedTerm
93 N4dc568b4992b41d7b31043460f127c1c schema:name Springer Nature
94 rdf:type schema:Organisation
95 N50de57a3753a42f0aa3fbd8a4a72068d rdf:first N431f14b1b93d4828a08761d3d88df57d
96 rdf:rest rdf:nil
97 N5311c7305e1e4b8fa5d131bc6a875073 schema:name pubmed_id
98 schema:value 35237979
99 rdf:type schema:PropertyValue
100 N5c219c5ceb444c18a865a803035a219f schema:affiliation grid-institutes:grid.267500.6
101 schema:familyName Suzuki
102 schema:givenName Ritsuko
103 rdf:type schema:Person
104 N5cd449eb70a04e689ac3adf40f0e5d25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cholesterol
106 rdf:type schema:DefinedTerm
107 N7ee0245bea254218be47f3f3c8762fed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Cholesterol, Dietary
109 rdf:type schema:DefinedTerm
110 N90ae85284f4046ac8bebec6cadf383a5 rdf:first sg:person.01037035370.11
111 rdf:rest N2fee79883224463c9b7535e241d5c243
112 N944aa621e32948f282f5739f0b590994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Disease Models, Animal
114 rdf:type schema:DefinedTerm
115 Na0ceebe8f6164bd5a0590c0bffdc6086 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Rabbits
117 rdf:type schema:DefinedTerm
118 Nc1b87248eb2047a0bb9c7a6d0195c606 schema:name dimensions_id
119 schema:value pub.1145981065
120 rdf:type schema:PropertyValue
121 Nd1c9f75fc1c54025b8c6f7b67c927018 schema:isbn 978-1-0716-1923-0
122 978-1-0716-1924-7
123 schema:name Atherosclerosis
124 rdf:type schema:Book
125 Nff61463f07b843edb68965a69db4ebe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Atherosclerosis
127 rdf:type schema:DefinedTerm
128 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
129 schema:name Chemical Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:0399 schema:inDefinedTermSet anzsrc-for:
132 schema:name Other Chemical Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
135 schema:name Biological Sciences
136 rdf:type schema:DefinedTerm
137 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
138 schema:name Biochemistry and Cell Biology
139 rdf:type schema:DefinedTerm
140 sg:person.01037035370.11 schema:affiliation grid-institutes:grid.500400.1
141 schema:familyName Chen
142 schema:givenName Yajie
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037035370.11
144 rdf:type schema:Person
145 sg:person.01115327172.22 schema:affiliation grid-institutes:grid.267500.6
146 schema:familyName Niimi
147 schema:givenName Manabu
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115327172.22
149 rdf:type schema:Person
150 sg:person.01136672602.49 schema:affiliation grid-institutes:grid.500400.1
151 schema:familyName Fan
152 schema:givenName Jianglin
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136672602.49
154 rdf:type schema:Person
155 sg:person.016446245112.43 schema:affiliation grid-institutes:grid.43169.39
156 schema:familyName Liu
157 schema:givenName Enqi
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016446245112.43
159 rdf:type schema:Person
160 grid-institutes:grid.267500.6 schema:alternateName Admission Center, University of Yamanashi, Kofu, Japan
161 Department of Molecular Pathology, Faculty of Medicine, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Japan
162 schema:name Admission Center, University of Yamanashi, Kofu, Japan
163 Department of Molecular Pathology, Faculty of Medicine, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Japan
164 rdf:type schema:Organization
165 grid-institutes:grid.43169.39 schema:alternateName Research Institute of Atherosclerotic Disease and Laboratory Animal Center, Xi’an Jiaotong University School of Medicine, Xi’an, China
166 schema:name Research Institute of Atherosclerotic Disease and Laboratory Animal Center, Xi’an Jiaotong University School of Medicine, Xi’an, China
167 rdf:type schema:Organization
168 grid-institutes:grid.500400.1 schema:alternateName School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China
169 schema:name Department of Molecular Pathology, Faculty of Medicine, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Japan
170 School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China
171 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...