A Polymer Physics Model to Dissect Genome Organization in Healthy and Pathological Phenotypes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2021-08-21

AUTHORS

Mattia Conte , Luca Fiorillo , Simona Bianco , Andrea M. Chiariello , Andrea Esposito , Francesco Musella , Francesco Flora , Alex Abraham , Mario Nicodemi

ABSTRACT

Novel technologies revealed a nontrivial spatial organization of the chromosomes within the cell nucleus, which includes different levels of compartmentalization and architectural patterns. Notably, such complex three-dimensional structure plays a crucial role in vital biological functions and its alterations can produce extensive rewiring of genomic regulatory regions, thus leading to gene misexpression and disease. Here, we show that theoretical and computational approaches, based on polymer physics, can be employed to dissect chromatin contacts in three-dimensional space and to predict the effects of pathogenic structural variants on the genome architecture. In particular, we discuss the folding of the human EPHA4 and the murine Pitx1 loci as case studies. More... »

PAGES

307-316

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-0716-1390-0_16

DOI

http://dx.doi.org/10.1007/978-1-0716-1390-0_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1140550502

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34415543


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