Ras GEF Mouse Models for the Analysis of Ras Biology and Signaling View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2021-05-12

AUTHORS

Alberto Fernández-Medarde , Eugenio Santos

ABSTRACT

Animal modelsModels have become in recent years a crucial tool to understand the physiological and pathological roles of many cellular proteins. They allow analysis of the functional consequences of [1] complete or partial (time- or organ-limited) removal of specific proteins (knockout animals), [2] the exchange of a wild-type allele for a mutantRasmutants or truncated version found in human illnesses (knock-in), or [3] the effect of overexpression of a given protein in the whole body or in specific organs (transgenicTransgenic mice). In this regard, the study of phenotypes in Ras GEF animal modelsModels has allowed researchers to find specific functions for otherwise very similar proteins, uncovering their role in physiological contexts such as memory formation, lymphopoiesis, photoreception, or body homeostasis. In addition, mouse modelsMouse models have been used to unveil the functional role of Ras GEFsGuanine nucleotide exchange factors (GEFs) under pathological conditions, including Noonan syndrome, skin tumorigenesis, inflammatory diseases, diabetes, or ischemia among others. In the following sections, we will describe the methodological approaches employed for Ras GEF animal modelModels analyses, as well as the main discoveries made. More... »

PAGES

361-395

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-0716-1190-6_23

DOI

http://dx.doi.org/10.1007/978-1-0716-1190-6_23

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1137930725

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33977490


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