How to Annotate and Submit a Short Linear Motif to the Eukaryotic Linear Motif Resource View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2020-07-22

AUTHORS

Marc Gouw , Jesús Alvarado-Valverde , Jelena Čalyševa , Francesca Diella , Manjeet Kumar , Sushama Michael , Kim Van Roey , Holger Dinkel , Toby J. Gibson

ABSTRACT

Over the past few years, it has become apparent that approximately 35% of the human proteome consists of intrinsically disordered regions. Many of these disordered regions are rich in short linear motifs (SLiMs) which mediate protein–protein interactions. Although these motifs are short and often partially conserved, they are involved in many important aspects of protein function, including cleavage, targeting, degradation, docking, phosphorylation, and other posttranslational modifications. The Eukaryotic Linear Motif resource (ELM) was established over 15 years ago as a repository to store and catalogue the scientific discoveries of motifs. Each motif in the database is annotated and curated manually, based on the experimental evidence gathered from publications. The entries themselves are submitted to ELM by filling in two annotation templates designed for motif class and motif instance annotation. In this protocol, we describe the steps involved in annotating new motifs and how to submit them to ELM. More... »

PAGES

73-102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-0716-0524-0_4

DOI

http://dx.doi.org/10.1007/978-1-0716-0524-0_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1129537160

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32696353


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189 grid-institutes:grid.7700.0 schema:alternateName Faculty of Biosciences, Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Heidelberg, Germany
190 schema:name Faculty of Biosciences, Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Heidelberg, Germany
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