Tolerance and cytokine profiles in sensitized transplant recipients View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

Jochen Binder , Jerzy W. Kupiec-Weglinski

ABSTRACT

The immediate and fulminant rejection of human renal allografts in sensitized recipients was first described more than 30 years ago [1]. The process of hyperacute rejection, occurring within minutes or hours after revascularization, is thought to be primarily mediated by pre-existing anti-donor antibodies (Abs) [2]. That it has become rare in recent years is primarily ascribed to improved crossmatching techniques [3]. However, at present, over 20% of patients with end-stage renal disease on waiting transplant lists are considered highly sensitized. Apart from prior failed allografts, this may result from blood transfusions or pregnancies. These highly sensitized patients experience an increased rate of graft rejection, compared to unsensitized individuals, which is often irreversible and unresponsive to currently used immunosuppressive therapy. More... »

PAGES

97-105

References to SciGraph publications

Book

TITLE

Retransplantation

ISBN

978-0-7923-4937-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-0-585-38142-8_13

DOI

http://dx.doi.org/10.1007/978-0-585-38142-8_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007528327


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