COP-Mediated Vesicle Transport View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Silvere Pagant , Elizabeth Miller

ABSTRACT

Transport of lipid and protein within the early secretory pathway is mediated by small transport vesicles that act as molecular taxis, shuttling cargoes between the endoplasmic reticulum (ER) and Golgi apparatus and within the Golgi. These vesicles are sculpted from donor organelles by distinct sets of cytoplasmic coat proteins that deform the lipid bilayer into a highly curved structure while selecting specific cargo proteins for efficient delivery to the acceptor organelle. The COPII coat generates vesicles from the ER membrane that transport newly synthesized proteins to the Golgi, whereas the COPI coat creates vesicles that mediate both retrograde Golgi-to-ER and intra-Golgi trafficking. These distinct cytoplasmic coats represent the minimal machinery required for vesicle formation and share some common mechanisms to drive intracellular protein transport. This chapter highlights the molecular details of COPII- and COPI-mediated vesicular traffic. More... »

PAGES

143-158

Book

TITLE

Trafficking Inside Cells

ISBN

978-0-387-93876-9
978-0-387-93877-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-0-387-93877-6_8

DOI

http://dx.doi.org/10.1007/978-0-387-93877-6_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043618437


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