CNS Drug Delivery: Opioid Peptides and the Blood-Brain Barrier View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2008

AUTHORS

Ken A. Witt , Thomas P. Davis

ABSTRACT

Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious “hybrid” peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future. More... »

PAGES

511-533

References to SciGraph publications

  • 1979-01. Quantitative estimate of pinocytosis in experimental acute hypertension in ACTA NEUROPATHOLOGICA
  • 1985-03. Changes in the integrity of the blood-brain barrier in suckling rats with low dose lead encephalopathy in ACTA NEUROPATHOLOGICA
  • 1995-10. Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain Barrier in PHARMACEUTICAL RESEARCH
  • 2000-06. A quantitative evaluation of the permeability of the blood brain barrier of portacaval shunted rats in METABOLIC BRAIN DISEASE
  • 1996-03. The blood-brain barrier and selective vulnerability in experimental thiamine-deficiency encephalopathy in the mouse in METABOLIC BRAIN DISEASE
  • 1990-09. Prodrugs of Peptides. 6. Bioreversible Derivatives of Thyrotropin-Releasing Hormone (TRH) with Increased Lipophilicity and Resistance to Cleavage by the TRH-Specific Serum Enzyme in PHARMACEUTICAL RESEARCH
  • 1999-07. Extended blood half-life of monomethoxypolyethylene glycol-conjugated hen lysozyme is a key parameter controlling immunological tolerogenicity in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1983-09. Ultracytochemical studies of vesicular and canalicular transport structures in the injured mammalian blood-brain barrier in ACTA NEUROPATHOLOGICA
  • 1997-10. The Effect of β-Turn Structure on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers in PHARMACEUTICAL RESEARCH
  • 1991-07. Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration in INFLAMMATION RESEARCH
  • 2000-02. Tight Junctions of the Blood–Brain Barrier in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 2000-12. Development of Novel Lipophilic Derivatives of DADLE (Leucine Enkephalin Analogue): Intestinal Permeability Characteristics of DADLE Derivatives in Rats in PHARMACEUTICAL RESEARCH
  • 1992-07. Reversal of multidrug resistance by surfactants in BRITISH JOURNAL OF CANCER
  • 1992-04. Absorptive-Mediated Endocytosis of an Adrenocorticotropic Hormone (ACTH) Analogue, Ebiratide, into the Blood–Brain Barrier: Studies with Monolayers of Primary Cultured Bovine Brain Capillary Endothelial Cells in PHARMACEUTICAL RESEARCH
  • 2003-07. RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain in NATURE MEDICINE
  • 1998. PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimisation of coupling techniques. in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 1999-01. Acyloxyalkoxy-Based Cyclic Prodrugs of Opioid Peptides: Evaluation of the Chemical and Enzymatic Stability as Well as Their Transport Properties Across Caco-2 Cell Monolayers in PHARMACEUTICAL RESEARCH
  • 2000-04. Determinants of Passive Drug Entry into the Central Nervous System in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 1985-06. Blood-brain barrier impairment by low pH buffer perfusion via the internal carotid artery in rat in ACTA NEUROPATHOLOGICA
  • 2003-10. Development of the blood-brain barrier in CELL AND TISSUE RESEARCH
  • 1989-11. Blood-brain barrier permeability and vascular reactivity to bradykinin after pretreatment with dexamethasone in ACTA NEUROPATHOLOGICA
  • 1994-03. Hydrogen Bonding Potential as a Determinant of the in Vitro and in Situ Blood–Brain Barrier Permeability of Peptides in PHARMACEUTICAL RESEARCH
  • 1992-09. Enhanced Delivery of 5-Iodo-2′-Deoxyuridine to the Brain Parenchyma in PHARMACEUTICAL RESEARCH
  • 1997-08. Lead-induced abnormalities in blood-brain barrier permeability in experimental chronic toxicity in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2000-04. Osmotic Opening of the Blood–Brain Barrier: Principles, Mechanism, and Therapeutic Applications in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 2004-12. Effect of Pluronic P85 on ATPase Activity of Drug Efflux Transporters in PHARMACEUTICAL RESEARCH
  • 1991-02. Blood-brain barrier alterations in bacterial meningitis: Development of an in vitro model and observations on the effects of lipopolysaccharide in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY
  • 1993-09. Peptide Stability in Drug Development. II. Effect of Single Amino Acid Substitution and Glycosylation on Peptide Reactivity in Human Serum in PHARMACEUTICAL RESEARCH
  • 1986. Pathophysiological Aspects of Blood-Brain Barrier Permeability in Epileptic Seizures in EXCITATORY AMINO ACIDS AND EPILEPSY
  • Book

    TITLE

    Drug Addiction

    ISBN

    978-0-387-76677-5
    978-0-387-76678-2

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-0-387-76678-2_30

    DOI

    http://dx.doi.org/10.1007/978-0-387-76678-2_30

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003108005


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Pharmacology and Pharmaceutical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University, Edwardsville, 200 University Park Drive, 62026, Edwardsville, IL., USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Witt", 
            "givenName": "Ken A.", 
            "id": "sg:person.01176566423.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176566423.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Arizona", 
              "id": "https://www.grid.ac/institutes/grid.134563.6", 
              "name": [
                "Department of Medical Pharmacology, College of Medicine, The University of Arizona, LSN 542, 1501 N. Campbell Avenue, 85724, Tucson, Arizona"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davis", 
            "givenName": "Thomas P.", 
            "id": "sg:person.0600744321.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600744321.17"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1023/a:1012152117703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000305289", 
              "https://doi.org/10.1023/a:1012152117703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01986590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000688948", 
              "https://doi.org/10.1007/bf01986590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01986590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000688948", 
              "https://doi.org/10.1007/bf01986590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mvr.2004.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001050241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0005-2736(97)00115-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003665719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1015933504191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003930090", 
              "https://doi.org/10.1023/a:1015933504191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.12.5592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004478722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02080931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006411346", 
              "https://doi.org/10.1007/bf02080931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02080931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006411346", 
              "https://doi.org/10.1007/bf02080931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1432-1033.1993.tb18347.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006609084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(00)00139-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006924620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.51.8.1058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006974132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.15.7114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007964413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008474342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1018953309913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009265478", 
              "https://doi.org/10.1023/a:1018953309913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005072-197007000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009555889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci110793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009637855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0196-9781(01)00537-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009838904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-003-0751-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010600396", 
              "https://doi.org/10.1007/s00441-003-0751-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-003-0751-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010600396", 
              "https://doi.org/10.1007/s00441-003-0751-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1520-6017(200011)89:11<1371::aid-jps1>3.0.co;2-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010724422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1997.69031236.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010806411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011304929", 
              "https://doi.org/10.1038/nm890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011304929", 
              "https://doi.org/10.1038/nm890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(99)00250-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011575804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s000180050365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012094168", 
              "https://doi.org/10.1007/s000180050365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0026-2862(90)90064-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012219932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci112407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012697429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02679976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013372981", 
              "https://doi.org/10.1007/bf02679976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02679976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013372981", 
              "https://doi.org/10.1007/bf02679976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1748-1716.1985.tb07746.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013477597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1999.0720238.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013739899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00688948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014016197", 
              "https://doi.org/10.1007/bf00688948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00688948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014016197", 
              "https://doi.org/10.1007/bf00688948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1006995910836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014612890", 
              "https://doi.org/10.1023/a:1006995910836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02630996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015269375", 
              "https://doi.org/10.1007/bf02630996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1007644706286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015807658", 
              "https://doi.org/10.1023/a:1007644706286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0024-3205(97)00597-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016972470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0024-3205(96)00380-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017026379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci2029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017510731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.neuro.22.1.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018977293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.104.069393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019318827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-004-7675-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019470067", 
              "https://doi.org/10.1007/s11095-004-7675-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0142-9612(00)00193-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020015933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(79)90159-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020027954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(79)90159-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020027954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.103.064006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020236993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0079-6336(88)80001-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020382540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1018854308829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022588007", 
              "https://doi.org/10.1023/a:1018854308829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000157851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022964296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.490050303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023075595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1248/bpb1978.13.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023351497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.12.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023488129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00684811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023560660", 
              "https://doi.org/10.1007/bf00684811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00684811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023560660", 
              "https://doi.org/10.1007/bf00684811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js970357+", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023721340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1999.9930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023797219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci111290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023988533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(00)02794-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024166897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2004.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024359292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.102.039545", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025174598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0169-328x(94)90222-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025416245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0169-328x(94)90222-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025416245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.2003.01582.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025419095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2002.tb00430.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026243412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(79)90414-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026375175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(79)90414-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026375175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1992.217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027185723", 
              "https://doi.org/10.1038/bjc.1992.217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1992.217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027185723", 
              "https://doi.org/10.1038/bjc.1992.217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-328x(99)00007-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028458758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tetasy.2004.11.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028750424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-199206000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029508252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-199206000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029508252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1018969222130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030251918", 
              "https://doi.org/10.1023/a:1018969222130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.2042-7158.1996.tb07112.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030395367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(00)00122-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030862922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1007049806660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031306463", 
              "https://doi.org/10.1023/a:1007049806660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.2.632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031650614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(95)00492-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032037156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(98)00090-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032712309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(86)90870-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032877410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(86)90870-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032877410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(98)00084-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032955367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1015803922401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033231559", 
              "https://doi.org/10.1023/a:1015803922401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0028-3908(86)90037-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033568095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0028-3908(86)90037-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033568095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.901520402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033795312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.901520402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033795312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0031-6989(85)90019-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033840657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1098-1128(200009)20:5<367::aid-med3>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034576598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1015848531603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034871513", 
              "https://doi.org/10.1023/a:1015848531603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-186x(200007)21:5<338::aid-bem2>3.0.co;2-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035021957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.1997.tb48517.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035214569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0173(91)90020-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035579194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0173(91)90020-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035579194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awh007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035610899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0196-9781(99)00127-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036304574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02815125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036308823", 
              "https://doi.org/10.1007/bf02815125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02815125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036308823", 
              "https://doi.org/10.1007/bf02815125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000112242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037025717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bem.2250110402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037587338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bem.2250110402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037587338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.16.5774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038546880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.140210597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038693636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005072-198409000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039014658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.10417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039497599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.2042-7158.1992.tb05469.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039577868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1016254514167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040149505", 
              "https://doi.org/10.1023/a:1016254514167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(90)90133-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041476325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(90)90133-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041476325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0196-9781(82)90173-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041515617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(99)00042-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041604463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(98)00087-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041684364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(83)90538-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043429059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(83)90538-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043429059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1989.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043719991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1989.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043719991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(81)90398-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044133904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(81)90398-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044133904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1399-3011.1999.00071.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044207340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1399-3011.1999.00071.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044207340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.40.3.648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044485643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-328x(99)00332-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044808838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2004.07.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045237321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(97)00323-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045689158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-2236(85)90140-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045837384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-2236(85)90140-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045837384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.2600840604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046143707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2004.02502.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046498908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js980410+", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046683986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4684-7971-3_13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047092770", 
              "https://doi.org/10.1007/978-1-4684-7971-3_13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1345/aph.10054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048172043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1345/aph.10054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048172043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(95)00023-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048343551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1975.tb04415.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048568136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-4347(00)82175-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049433808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2005.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049478541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00687884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049479637", 
              "https://doi.org/10.1007/bf00687884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00687884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049479637", 
              "https://doi.org/10.1007/bf00687884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bioorg.2004.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049889689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00691992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049897352", 
              "https://doi.org/10.1007/bf00691992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00691992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049897352", 
              "https://doi.org/10.1007/bf00691992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1993.tb03223.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049977679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0730-725x(94)92533-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050749926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0041-008x(73)90084-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051690023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1399-3011.1999.00076.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051964905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1399-3011.1999.00076.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051964905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00688639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052120338", 
              "https://doi.org/10.1007/bf00688639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00688639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052120338", 
              "https://doi.org/10.1007/bf00688639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.11.7011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052224650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005072-197905000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052354479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000054640", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053140675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0300-9629(73)90481-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053160274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0300-9629(73)90481-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053160274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.2000.0750424.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053282001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1007001923498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053312255", 
              "https://doi.org/10.1023/a:1007001923498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0925-5710(98)00039-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054664164", 
              "https://doi.org/10.1016/s0925-5710(98)00039-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac035491v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac035491v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054995611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc00029a005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc00032a009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00280a013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055168463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja0268635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055831082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja0268635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055831082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm000077y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055932350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm000077y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055932350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00082a008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055934471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00114a026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055935677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00396a038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055946165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm960356e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055957701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm960356e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055957701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm970119r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055958174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm970119r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055958174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm980374r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055958963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm980374r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055958963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm9810699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055959270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm9810699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055959270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs0670035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056721983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs0670035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056721983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006123-199805000-00082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060247650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1166305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062459060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203303lu501oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203303lu501oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1191/0961203303lu501oa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064154383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo-126-2-977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064263121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1381612013398310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069164576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.39.9.1040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070736176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/1282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070913582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1970.32.2.0127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071089231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1970.32.2.0127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071089231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1970.32.2.0127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071089231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1970.32.2.0127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071089231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1970.32.2.0127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071089231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/jns.1970.32.2.0127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071089231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074272681", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/096368979900800114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074462214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/096368979900800114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074462214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.20-21-08153.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074718190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074751783", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074849911", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076617608", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076972763", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077203375", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077360848", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077443211", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079048938", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079092058", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079409485", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079477910", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081023901", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081884598", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081891539", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082190674", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082263426", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082461044", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082563414", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082778645", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082786678", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082788632", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082900345", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082954759", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083060266", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083131545", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083245453", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083344047", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2008", 
        "datePublishedReg": "2008-01-01", 
        "description": "Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious \u201chybrid\u201d peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future.", 
        "editor": [
          {
            "familyName": "Rapaka", 
            "givenName": "Rao S.", 
            "type": "Person"
          }, 
          {
            "familyName": "Sad\u00e9e", 
            "givenName": "Wolfgang", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-0-387-76678-2_30", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": {
          "isbn": [
            "978-0-387-76677-5", 
            "978-0-387-76678-2"
          ], 
          "name": "Drug Addiction", 
          "type": "Book"
        }, 
        "name": "CNS Drug Delivery: Opioid Peptides and the Blood-Brain Barrier", 
        "pagination": "511-533", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1003108005"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-0-387-76678-2_30"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0ece00a796bf9e0c0b6e7a5b6912eb41642f4996a70cfba012558c1ffdd6fc75"
            ]
          }
        ], 
        "publisher": {
          "location": "New York, NY", 
          "name": "Springer New York", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-0-387-76678-2_30", 
          "https://app.dimensions.ai/details/publication/pub.1003108005"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-16T07:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000356_0000000356/records_57865_00000000.jsonl", 
        "type": "Chapter", 
        "url": "https://link.springer.com/10.1007%2F978-0-387-76678-2_30"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-76678-2_30'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-76678-2_30'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-76678-2_30'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-76678-2_30'


     

    This table displays all metadata directly associated to this object as RDF triples.

    617 TRIPLES      23 PREDICATES      206 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-0-387-76678-2_30 schema:about anzsrc-for:11
    2 anzsrc-for:1115
    3 schema:author N44773c96a4734f26af70b393a7d10722
    4 schema:citation sg:pub.10.1007/978-1-4684-7971-3_13
    5 sg:pub.10.1007/bf00684811
    6 sg:pub.10.1007/bf00687884
    7 sg:pub.10.1007/bf00688639
    8 sg:pub.10.1007/bf00688948
    9 sg:pub.10.1007/bf00691992
    10 sg:pub.10.1007/bf01986590
    11 sg:pub.10.1007/bf02080931
    12 sg:pub.10.1007/bf02630996
    13 sg:pub.10.1007/bf02679976
    14 sg:pub.10.1007/bf02815125
    15 sg:pub.10.1007/s000180050365
    16 sg:pub.10.1007/s00441-003-0751-z
    17 sg:pub.10.1007/s11095-004-7675-5
    18 sg:pub.10.1016/s0925-5710(98)00039-5
    19 sg:pub.10.1023/a:1006995910836
    20 sg:pub.10.1023/a:1007001923498
    21 sg:pub.10.1023/a:1007049806660
    22 sg:pub.10.1023/a:1007644706286
    23 sg:pub.10.1023/a:1012152117703
    24 sg:pub.10.1023/a:1015803922401
    25 sg:pub.10.1023/a:1015848531603
    26 sg:pub.10.1023/a:1015933504191
    27 sg:pub.10.1023/a:1016254514167
    28 sg:pub.10.1023/a:1018854308829
    29 sg:pub.10.1023/a:1018953309913
    30 sg:pub.10.1023/a:1018969222130
    31 sg:pub.10.1038/bjc.1992.217
    32 sg:pub.10.1038/nm890
    33 https://app.dimensions.ai/details/publication/pub.1074272681
    34 https://app.dimensions.ai/details/publication/pub.1074751783
    35 https://app.dimensions.ai/details/publication/pub.1074849911
    36 https://app.dimensions.ai/details/publication/pub.1076617608
    37 https://app.dimensions.ai/details/publication/pub.1076972763
    38 https://app.dimensions.ai/details/publication/pub.1077203375
    39 https://app.dimensions.ai/details/publication/pub.1077360848
    40 https://app.dimensions.ai/details/publication/pub.1077443211
    41 https://app.dimensions.ai/details/publication/pub.1079048938
    42 https://app.dimensions.ai/details/publication/pub.1079092058
    43 https://app.dimensions.ai/details/publication/pub.1079409485
    44 https://app.dimensions.ai/details/publication/pub.1079477910
    45 https://app.dimensions.ai/details/publication/pub.1081023901
    46 https://app.dimensions.ai/details/publication/pub.1081884598
    47 https://app.dimensions.ai/details/publication/pub.1081891539
    48 https://app.dimensions.ai/details/publication/pub.1082190674
    49 https://app.dimensions.ai/details/publication/pub.1082263426
    50 https://app.dimensions.ai/details/publication/pub.1082461044
    51 https://app.dimensions.ai/details/publication/pub.1082563414
    52 https://app.dimensions.ai/details/publication/pub.1082778645
    53 https://app.dimensions.ai/details/publication/pub.1082786678
    54 https://app.dimensions.ai/details/publication/pub.1082788632
    55 https://app.dimensions.ai/details/publication/pub.1082900345
    56 https://app.dimensions.ai/details/publication/pub.1082954759
    57 https://app.dimensions.ai/details/publication/pub.1083060266
    58 https://app.dimensions.ai/details/publication/pub.1083131545
    59 https://app.dimensions.ai/details/publication/pub.1083245453
    60 https://app.dimensions.ai/details/publication/pub.1083344047
    61 https://doi.org/10.1002/1098-1128(200009)20:5<367::aid-med3>3.0.co;2-p
    62 https://doi.org/10.1002/1520-6017(200011)89:11<1371::aid-jps1>3.0.co;2-d
    63 https://doi.org/10.1002/1521-186x(200007)21:5<338::aid-bem2>3.0.co;2-q
    64 https://doi.org/10.1002/bem.2250110402
    65 https://doi.org/10.1002/cne.901520402
    66 https://doi.org/10.1002/jcp.10417
    67 https://doi.org/10.1002/jnr.490050303
    68 https://doi.org/10.1002/jps.2600840604
    69 https://doi.org/10.1002/path.1434
    70 https://doi.org/10.1006/bbrc.1999.9930
    71 https://doi.org/10.1016/0006-8993(79)90414-1
    72 https://doi.org/10.1016/0006-8993(81)90398-x
    73 https://doi.org/10.1016/0006-8993(86)90870-x
    74 https://doi.org/10.1016/0006-8993(95)00023-j
    75 https://doi.org/10.1016/0014-2999(90)90133-q
    76 https://doi.org/10.1016/0014-2999(95)00492-0
    77 https://doi.org/10.1016/0024-3205(79)90159-0
    78 https://doi.org/10.1016/0024-3205(83)90538-6
    79 https://doi.org/10.1016/0026-2862(90)90064-x
    80 https://doi.org/10.1016/0028-3908(86)90037-7
    81 https://doi.org/10.1016/0031-6989(85)90019-0
    82 https://doi.org/10.1016/0041-008x(73)90084-7
    83 https://doi.org/10.1016/0165-0173(91)90020-9
    84 https://doi.org/10.1016/0166-2236(85)90140-7
    85 https://doi.org/10.1016/0169-328x(94)90222-4
    86 https://doi.org/10.1016/0196-9781(82)90173-5
    87 https://doi.org/10.1016/0300-9629(73)90481-7
    88 https://doi.org/10.1016/0730-725x(94)92533-x
    89 https://doi.org/10.1016/j.bbrc.2004.12.123
    90 https://doi.org/10.1016/j.bioorg.2004.05.011
    91 https://doi.org/10.1016/j.jneuroim.2004.11.011
    92 https://doi.org/10.1016/j.mvr.2004.07.005
    93 https://doi.org/10.1016/j.neuron.2004.07.017
    94 https://doi.org/10.1016/j.tetasy.2004.11.038
    95 https://doi.org/10.1016/j.tins.2005.02.001
    96 https://doi.org/10.1016/s0005-2736(97)00115-6
    97 https://doi.org/10.1016/s0006-8993(00)02794-3
    98 https://doi.org/10.1016/s0006-8993(97)00323-5
    99 https://doi.org/10.1016/s0024-3205(96)00380-3
    100 https://doi.org/10.1016/s0024-3205(97)00597-3
    101 https://doi.org/10.1016/s0079-6336(88)80001-9
    102 https://doi.org/10.1016/s0142-9612(00)00193-9
    103 https://doi.org/10.1016/s0168-3659(99)00042-5
    104 https://doi.org/10.1016/s0168-3659(99)00250-3
    105 https://doi.org/10.1016/s0169-328x(99)00007-8
    106 https://doi.org/10.1016/s0169-328x(99)00332-0
    107 https://doi.org/10.1016/s0169-409x(00)00122-8
    108 https://doi.org/10.1016/s0169-409x(00)00139-3
    109 https://doi.org/10.1016/s0169-409x(98)00084-2
    110 https://doi.org/10.1016/s0169-409x(98)00087-8
    111 https://doi.org/10.1016/s0169-409x(98)00090-8
    112 https://doi.org/10.1016/s0196-9781(01)00537-x
    113 https://doi.org/10.1016/s0196-9781(99)00127-8
    114 https://doi.org/10.1016/s0378-4347(00)82175-1
    115 https://doi.org/10.1021/ac035491v
    116 https://doi.org/10.1021/bc00029a005
    117 https://doi.org/10.1021/bc00032a009
    118 https://doi.org/10.1021/bi00280a013
    119 https://doi.org/10.1021/ja0268635
    120 https://doi.org/10.1021/jm000077y
    121 https://doi.org/10.1021/jm00082a008
    122 https://doi.org/10.1021/jm00114a026
    123 https://doi.org/10.1021/jm00396a038
    124 https://doi.org/10.1021/jm960356e
    125 https://doi.org/10.1021/jm970119r
    126 https://doi.org/10.1021/jm980374r
    127 https://doi.org/10.1021/jm9810699
    128 https://doi.org/10.1021/js970357+
    129 https://doi.org/10.1021/js980410+
    130 https://doi.org/10.1034/j.1399-3011.1999.00071.x
    131 https://doi.org/10.1034/j.1399-3011.1999.00076.x
    132 https://doi.org/10.1038/jcbfm.1989.10
    133 https://doi.org/10.1042/cs0670035
    134 https://doi.org/10.1046/j.1471-4159.1997.69031236.x
    135 https://doi.org/10.1046/j.1471-4159.1999.0720238.x
    136 https://doi.org/10.1046/j.1471-4159.2000.0750424.x
    137 https://doi.org/10.1046/j.1471-4159.2003.01582.x
    138 https://doi.org/10.1073/pnas.140210597
    139 https://doi.org/10.1073/pnas.83.16.5774
    140 https://doi.org/10.1073/pnas.85.2.632
    141 https://doi.org/10.1073/pnas.91.15.7114
    142 https://doi.org/10.1073/pnas.92.12.5592
    143 https://doi.org/10.1074/jbc.274.11.7011
    144 https://doi.org/10.1083/jcb.40.3.648
    145 https://doi.org/10.1093/brain/awh007
    146 https://doi.org/10.1097/00001813-199206000-00001
    147 https://doi.org/10.1097/00005072-197007000-00007
    148 https://doi.org/10.1097/00005072-197905000-00003
    149 https://doi.org/10.1097/00005072-198409000-00004
    150 https://doi.org/10.1097/00006123-199805000-00082
    151 https://doi.org/10.1111/j.1432-1033.1993.tb18347.x
    152 https://doi.org/10.1111/j.1471-4159.1975.tb04415.x
    153 https://doi.org/10.1111/j.1471-4159.1993.tb03223.x
    154 https://doi.org/10.1111/j.1471-4159.2004.02502.x
    155 https://doi.org/10.1111/j.1748-1716.1985.tb07746.x
    156 https://doi.org/10.1111/j.1749-6632.1997.tb48517.x
    157 https://doi.org/10.1111/j.1750-3639.2002.tb00430.x
    158 https://doi.org/10.1111/j.2042-7158.1992.tb05469.x
    159 https://doi.org/10.1111/j.2042-7158.1996.tb07112.x
    160 https://doi.org/10.1124/jpet.102.039545
    161 https://doi.org/10.1124/jpet.103.064006
    162 https://doi.org/10.1124/jpet.104.069393
    163 https://doi.org/10.1126/science.1166305
    164 https://doi.org/10.1136/jnnp.51.8.1058
    165 https://doi.org/10.1146/annurev.neuro.22.1.11
    166 https://doi.org/10.1159/000054640
    167 https://doi.org/10.1159/000112242
    168 https://doi.org/10.1159/000157851
    169 https://doi.org/10.1172/jci110793
    170 https://doi.org/10.1172/jci111290
    171 https://doi.org/10.1172/jci112407
    172 https://doi.org/10.1172/jci2029
    173 https://doi.org/10.1177/096368979900800114
    174 https://doi.org/10.1191/0961203303lu501oa
    175 https://doi.org/10.1210/endo-126-2-977
    176 https://doi.org/10.1248/bpb1978.13.10
    177 https://doi.org/10.1345/aph.10054
    178 https://doi.org/10.1523/jneurosci.20-21-08153.2000
    179 https://doi.org/10.2174/1381612013398310
    180 https://doi.org/10.2337/diab.39.9.1040
    181 https://doi.org/10.2741/1282
    182 https://doi.org/10.3171/jns.1970.32.2.0127
    183 schema:datePublished 2008
    184 schema:datePublishedReg 2008-01-01
    185 schema:description Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious “hybrid” peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future.
    186 schema:editor Nbb2bea62c8d64c70a6be22b6f229ccd8
    187 schema:genre chapter
    188 schema:inLanguage en
    189 schema:isAccessibleForFree true
    190 schema:isPartOf N7fbf820b5e1c41f4a666ec0dc39e5c1b
    191 schema:name CNS Drug Delivery: Opioid Peptides and the Blood-Brain Barrier
    192 schema:pagination 511-533
    193 schema:productId N2c7e10c896a34fd0824b881ccfcaebe6
    194 Na7f815786051441c8f9f813cc91a0a0e
    195 Naf045a7df78c424e842b383222dc8ff4
    196 schema:publisher N4eb86746fd5a48ac895ec527d8e1fc15
    197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003108005
    198 https://doi.org/10.1007/978-0-387-76678-2_30
    199 schema:sdDatePublished 2019-04-16T07:29
    200 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    201 schema:sdPublisher N62cb9cbe9a9f4c139f114cb6a4e9b41f
    202 schema:url https://link.springer.com/10.1007%2F978-0-387-76678-2_30
    203 sgo:license sg:explorer/license/
    204 sgo:sdDataset chapters
    205 rdf:type schema:Chapter
    206 N2c7e10c896a34fd0824b881ccfcaebe6 schema:name readcube_id
    207 schema:value 0ece00a796bf9e0c0b6e7a5b6912eb41642f4996a70cfba012558c1ffdd6fc75
    208 rdf:type schema:PropertyValue
    209 N44773c96a4734f26af70b393a7d10722 rdf:first sg:person.01176566423.66
    210 rdf:rest Nba7fb5059e534d9cbe7a2a3f014af2c7
    211 N4eb86746fd5a48ac895ec527d8e1fc15 schema:location New York, NY
    212 schema:name Springer New York
    213 rdf:type schema:Organisation
    214 N58420b3aadd941dab9892a465df12cbd schema:familyName Rapaka
    215 schema:givenName Rao S.
    216 rdf:type schema:Person
    217 N62cb9cbe9a9f4c139f114cb6a4e9b41f schema:name Springer Nature - SN SciGraph project
    218 rdf:type schema:Organization
    219 N7980996e4bd44611a9fac984930f3175 schema:familyName Sadée
    220 schema:givenName Wolfgang
    221 rdf:type schema:Person
    222 N7fbf820b5e1c41f4a666ec0dc39e5c1b schema:isbn 978-0-387-76677-5
    223 978-0-387-76678-2
    224 schema:name Drug Addiction
    225 rdf:type schema:Book
    226 Na7f815786051441c8f9f813cc91a0a0e schema:name doi
    227 schema:value 10.1007/978-0-387-76678-2_30
    228 rdf:type schema:PropertyValue
    229 Naf045a7df78c424e842b383222dc8ff4 schema:name dimensions_id
    230 schema:value pub.1003108005
    231 rdf:type schema:PropertyValue
    232 Nba7fb5059e534d9cbe7a2a3f014af2c7 rdf:first sg:person.0600744321.17
    233 rdf:rest rdf:nil
    234 Nbb2bea62c8d64c70a6be22b6f229ccd8 rdf:first N58420b3aadd941dab9892a465df12cbd
    235 rdf:rest Ncb11ac7109734499a38a4cd3b1d7e924
    236 Ncb11ac7109734499a38a4cd3b1d7e924 rdf:first N7980996e4bd44611a9fac984930f3175
    237 rdf:rest rdf:nil
    238 Nde1d80e8433342528c62da4f8b9e906e schema:name Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University, Edwardsville, 200 University Park Drive, 62026, Edwardsville, IL., USA
    239 rdf:type schema:Organization
    240 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    241 schema:name Medical and Health Sciences
    242 rdf:type schema:DefinedTerm
    243 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
    244 schema:name Pharmacology and Pharmaceutical Sciences
    245 rdf:type schema:DefinedTerm
    246 sg:person.01176566423.66 schema:affiliation Nde1d80e8433342528c62da4f8b9e906e
    247 schema:familyName Witt
    248 schema:givenName Ken A.
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176566423.66
    250 rdf:type schema:Person
    251 sg:person.0600744321.17 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
    252 schema:familyName Davis
    253 schema:givenName Thomas P.
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600744321.17
    255 rdf:type schema:Person
    256 sg:pub.10.1007/978-1-4684-7971-3_13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047092770
    257 https://doi.org/10.1007/978-1-4684-7971-3_13
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1007/bf00684811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023560660
    260 https://doi.org/10.1007/bf00684811
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1007/bf00687884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049479637
    263 https://doi.org/10.1007/bf00687884
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1007/bf00688639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052120338
    266 https://doi.org/10.1007/bf00688639
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1007/bf00688948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014016197
    269 https://doi.org/10.1007/bf00688948
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1007/bf00691992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049897352
    272 https://doi.org/10.1007/bf00691992
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/bf01986590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000688948
    275 https://doi.org/10.1007/bf01986590
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/bf02080931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006411346
    278 https://doi.org/10.1007/bf02080931
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1007/bf02630996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015269375
    281 https://doi.org/10.1007/bf02630996
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/bf02679976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013372981
    284 https://doi.org/10.1007/bf02679976
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/bf02815125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036308823
    287 https://doi.org/10.1007/bf02815125
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s000180050365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012094168
    290 https://doi.org/10.1007/s000180050365
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s00441-003-0751-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1010600396
    293 https://doi.org/10.1007/s00441-003-0751-z
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s11095-004-7675-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019470067
    296 https://doi.org/10.1007/s11095-004-7675-5
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1016/s0925-5710(98)00039-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054664164
    299 https://doi.org/10.1016/s0925-5710(98)00039-5
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1023/a:1006995910836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014612890
    302 https://doi.org/10.1023/a:1006995910836
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1023/a:1007001923498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053312255
    305 https://doi.org/10.1023/a:1007001923498
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1023/a:1007049806660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031306463
    308 https://doi.org/10.1023/a:1007049806660
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1023/a:1007644706286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015807658
    311 https://doi.org/10.1023/a:1007644706286
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1023/a:1012152117703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000305289
    314 https://doi.org/10.1023/a:1012152117703
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1023/a:1015803922401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033231559
    317 https://doi.org/10.1023/a:1015803922401
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1023/a:1015848531603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034871513
    320 https://doi.org/10.1023/a:1015848531603
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1023/a:1015933504191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003930090
    323 https://doi.org/10.1023/a:1015933504191
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1023/a:1016254514167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040149505
    326 https://doi.org/10.1023/a:1016254514167
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1023/a:1018854308829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022588007
    329 https://doi.org/10.1023/a:1018854308829
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1023/a:1018953309913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009265478
    332 https://doi.org/10.1023/a:1018953309913
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1023/a:1018969222130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030251918
    335 https://doi.org/10.1023/a:1018969222130
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/bjc.1992.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027185723
    338 https://doi.org/10.1038/bjc.1992.217
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nm890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011304929
    341 https://doi.org/10.1038/nm890
    342 rdf:type schema:CreativeWork
    343 https://app.dimensions.ai/details/publication/pub.1074272681 schema:CreativeWork
    344 https://app.dimensions.ai/details/publication/pub.1074751783 schema:CreativeWork
    345 https://app.dimensions.ai/details/publication/pub.1074849911 schema:CreativeWork
    346 https://app.dimensions.ai/details/publication/pub.1076617608 schema:CreativeWork
    347 https://app.dimensions.ai/details/publication/pub.1076972763 schema:CreativeWork
    348 https://app.dimensions.ai/details/publication/pub.1077203375 schema:CreativeWork
    349 https://app.dimensions.ai/details/publication/pub.1077360848 schema:CreativeWork
    350 https://app.dimensions.ai/details/publication/pub.1077443211 schema:CreativeWork
    351 https://app.dimensions.ai/details/publication/pub.1079048938 schema:CreativeWork
    352 https://app.dimensions.ai/details/publication/pub.1079092058 schema:CreativeWork
    353 https://app.dimensions.ai/details/publication/pub.1079409485 schema:CreativeWork
    354 https://app.dimensions.ai/details/publication/pub.1079477910 schema:CreativeWork
    355 https://app.dimensions.ai/details/publication/pub.1081023901 schema:CreativeWork
    356 https://app.dimensions.ai/details/publication/pub.1081884598 schema:CreativeWork
    357 https://app.dimensions.ai/details/publication/pub.1081891539 schema:CreativeWork
    358 https://app.dimensions.ai/details/publication/pub.1082190674 schema:CreativeWork
    359 https://app.dimensions.ai/details/publication/pub.1082263426 schema:CreativeWork
    360 https://app.dimensions.ai/details/publication/pub.1082461044 schema:CreativeWork
    361 https://app.dimensions.ai/details/publication/pub.1082563414 schema:CreativeWork
    362 https://app.dimensions.ai/details/publication/pub.1082778645 schema:CreativeWork
    363 https://app.dimensions.ai/details/publication/pub.1082786678 schema:CreativeWork
    364 https://app.dimensions.ai/details/publication/pub.1082788632 schema:CreativeWork
    365 https://app.dimensions.ai/details/publication/pub.1082900345 schema:CreativeWork
    366 https://app.dimensions.ai/details/publication/pub.1082954759 schema:CreativeWork
    367 https://app.dimensions.ai/details/publication/pub.1083060266 schema:CreativeWork
    368 https://app.dimensions.ai/details/publication/pub.1083131545 schema:CreativeWork
    369 https://app.dimensions.ai/details/publication/pub.1083245453 schema:CreativeWork
    370 https://app.dimensions.ai/details/publication/pub.1083344047 schema:CreativeWork
    371 https://doi.org/10.1002/1098-1128(200009)20:5<367::aid-med3>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1034576598
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1002/1520-6017(200011)89:11<1371::aid-jps1>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1010724422
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1002/1521-186x(200007)21:5<338::aid-bem2>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1035021957
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1002/bem.2250110402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037587338
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1002/cne.901520402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033795312
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1002/jcp.10417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039497599
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1002/jnr.490050303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023075595
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1002/jps.2600840604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046143707
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1002/path.1434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008474342
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1006/bbrc.1999.9930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023797219
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/0006-8993(79)90414-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026375175
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1016/0006-8993(81)90398-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044133904
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1016/0006-8993(86)90870-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032877410
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1016/0006-8993(95)00023-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1048343551
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1016/0014-2999(90)90133-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1041476325
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1016/0014-2999(95)00492-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032037156
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1016/0024-3205(79)90159-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020027954
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1016/0024-3205(83)90538-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043429059
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1016/0026-2862(90)90064-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012219932
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1016/0028-3908(86)90037-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033568095
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1016/0031-6989(85)90019-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033840657
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1016/0041-008x(73)90084-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051690023
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/0165-0173(91)90020-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035579194
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/0166-2236(85)90140-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045837384
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/0169-328x(94)90222-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025416245
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/0196-9781(82)90173-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041515617
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/0300-9629(73)90481-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053160274
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/0730-725x(94)92533-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050749926
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/j.bbrc.2004.12.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023488129
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/j.bioorg.2004.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049889689
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/j.jneuroim.2004.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024359292
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/j.mvr.2004.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001050241
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/j.neuron.2004.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045237321
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/j.tetasy.2004.11.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028750424
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.tins.2005.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049478541
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/s0005-2736(97)00115-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003665719
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/s0006-8993(00)02794-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024166897
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/s0006-8993(97)00323-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045689158
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/s0024-3205(96)00380-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017026379
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/s0024-3205(97)00597-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016972470
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/s0079-6336(88)80001-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020382540
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/s0142-9612(00)00193-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020015933
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/s0168-3659(99)00042-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041604463
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/s0168-3659(99)00250-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011575804
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/s0169-328x(99)00007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028458758
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/s0169-328x(99)00332-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044808838
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/s0169-409x(00)00122-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030862922
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/s0169-409x(00)00139-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006924620
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/s0169-409x(98)00084-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032955367
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/s0169-409x(98)00087-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041684364
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/s0169-409x(98)00090-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032712309
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/s0196-9781(01)00537-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009838904
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/s0196-9781(99)00127-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036304574
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/s0378-4347(00)82175-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049433808
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1021/ac035491v schema:sameAs https://app.dimensions.ai/details/publication/pub.1054995611
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1021/bc00029a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153017
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1021/bc00032a009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153086
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1021/bi00280a013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055168463
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1021/ja0268635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055831082
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1021/jm000077y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055932350
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1021/jm00082a008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055934471
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1021/jm00114a026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055935677
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1021/jm00396a038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055946165
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1021/jm960356e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055957701
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1021/jm970119r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055958174
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1021/jm980374r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055958963
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1021/jm9810699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055959270
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1021/js970357+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1023721340
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1021/js980410+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1046683986
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1034/j.1399-3011.1999.00071.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044207340
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1034/j.1399-3011.1999.00076.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051964905
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1038/jcbfm.1989.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043719991
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1042/cs0670035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056721983
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1046/j.1471-4159.1997.69031236.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010806411
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1046/j.1471-4159.1999.0720238.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013739899
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1046/j.1471-4159.2000.0750424.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053282001
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1046/j.1471-4159.2003.01582.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025419095
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1073/pnas.140210597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038693636
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1073/pnas.83.16.5774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038546880
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1073/pnas.85.2.632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031650614
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1073/pnas.91.15.7114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007964413
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1073/pnas.92.12.5592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004478722
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1074/jbc.274.11.7011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052224650
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1083/jcb.40.3.648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044485643
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1093/brain/awh007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035610899
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1097/00001813-199206000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029508252
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1097/00005072-197007000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009555889
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1097/00005072-197905000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052354479
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1097/00005072-198409000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039014658
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1097/00006123-199805000-00082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060247650
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1111/j.1432-1033.1993.tb18347.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006609084
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1111/j.1471-4159.1975.tb04415.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048568136
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1111/j.1471-4159.1993.tb03223.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049977679
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1111/j.1471-4159.2004.02502.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046498908
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1111/j.1748-1716.1985.tb07746.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013477597
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1111/j.1749-6632.1997.tb48517.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035214569
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1111/j.1750-3639.2002.tb00430.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026243412
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1111/j.2042-7158.1992.tb05469.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039577868
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1111/j.2042-7158.1996.tb07112.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030395367
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1124/jpet.102.039545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025174598
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1124/jpet.103.064006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020236993
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1124/jpet.104.069393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019318827
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1126/science.1166305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062459060
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1136/jnnp.51.8.1058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006974132
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1146/annurev.neuro.22.1.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018977293
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1159/000054640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053140675
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1159/000112242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037025717
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1159/000157851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022964296
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1172/jci110793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009637855
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1172/jci111290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023988533
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1172/jci112407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012697429
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1172/jci2029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017510731
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1177/096368979900800114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074462214
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1191/0961203303lu501oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1064154383
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1210/endo-126-2-977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064263121
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1248/bpb1978.13.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023351497
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1345/aph.10054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048172043
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1523/jneurosci.20-21-08153.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074718190
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.2174/1381612013398310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069164576
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.2337/diab.39.9.1040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070736176
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.2741/1282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070913582
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.3171/jns.1970.32.2.0127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071089231
    614 rdf:type schema:CreativeWork
    615 https://www.grid.ac/institutes/grid.134563.6 schema:alternateName University of Arizona
    616 schema:name Department of Medical Pharmacology, College of Medicine, The University of Arizona, LSN 542, 1501 N. Campbell Avenue, 85724, Tucson, Arizona
    617 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...