Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

James B. Knaak , Curt C. Dary , Miles S. Okino , Fred W. Power , Xiaofei Zhang , Carol B. Thompson , R. Tornero-Velez , Jerry N. Blancato

ABSTRACT

Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000). Table 1 Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.(a). More... »

PAGES

53-212

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-0-387-73163-6_3

    DOI

    http://dx.doi.org/10.1007/978-0-387-73163-6_3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002313040

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20614344


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