PTH Regulates the Hematopoietic Stem Cell Niche in Bone View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Henry M Kronenberg

ABSTRACT

In late fetal life, hematopoiesis moves from the liver to the bone marrow in mammals, and continues to occur throughout postnatal life, with extramedullary hematopoiesis occurring only when disease blocks hematopoiesis in the marrow. Hematopoietic stem cells (HSCs) are uniquely the cells that can generate cells of all hematopoietic lineages. These cells do so by balancing an ability to increase their number by proliferation while staying pleuripotent (self-renewal) with their ability to differentiate into any of the hematopoietic lineages. Hematopoietic stem cells also happen to be able to circulate in the systemic circulation, a property likely to be important in their normal function. One of the reasons that we have learned so much about hematopoietic stem cells is that their properties underlie the ability of transplanted bone marrow to populate the marrow of patient recipients with failing bone marrow. Clearly, the regulation of stem cell self-renewal and differentiation is crucial for normal function. A powerful idea that organizes a number of important properties of this regulation is that of the stem cell niche (Ohlstein, Kai, Decotto, et al. 2004; Scadden 2006). A niche is a particular place at which cells and matrix coalesce to regulate stem cells. This concept provides a source of the obvious need for paracrine regulation of stem cell properties. By providing a saturable number of sites for stem cell self-renewal, the niche also suggests a specific regulatory process: stem cells can enter and leave a niche and thus move toward or away from a unique site at which self renewal is possible. A recent series of advances has shown that hematopoietic stem cells can be found adjacent to both osteoblastic cells and endothelial cells in normal bone (Zhang, Niu, Ye, et al. 2003; Kiel, Yilmaz, Iwashita, et al. 2005). Here I will describe how activation of the PTH/PTHrP receptor found on cells of the osteoblast lineage can modify the niche for hematopoietic stem cells in bone in a way that allows such cells to accumulate in the marrow (Calvi, Adams, Weibrecht, et al. 2003). These findings have implications both for the normal regulation of hematopoiesis and for potential therapies in humans needing transplantation of human hematopoietic stem cells. More... »

PAGES

57-60

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-0-387-72009-8_7

DOI

http://dx.doi.org/10.1007/978-0-387-72009-8_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012101407

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17966388


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone and Bones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parathyroid Hormone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parathyroid Hormone-Related Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kronenberg", 
        "givenName": "Henry M", 
        "id": "sg:person.01005031757.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005031757.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature02040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003509222", 
          "https://doi.org/10.1038/nature02040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003509222", 
          "https://doi.org/10.1038/nature02040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2004.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007621368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199609053351004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008101955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci11296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016957718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2004.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032285616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033486035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033486035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033616640", 
          "https://doi.org/10.1038/nature02041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033616640", 
          "https://doi.org/10.1038/nature02041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047165782", 
          "https://doi.org/10.1038/nature04957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047165782", 
          "https://doi.org/10.1038/nature04957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047165782", 
          "https://doi.org/10.1038/nature04957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048721879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0508928103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049284168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2006.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052401014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-0036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064287633"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007", 
    "datePublishedReg": "2007-01-01", 
    "description": "In late fetal life, hematopoiesis moves from the liver to the bone marrow in mammals, and continues to occur throughout postnatal life, with extramedullary hematopoiesis occurring only when disease blocks hematopoiesis in the marrow. Hematopoietic stem cells (HSCs) are uniquely the cells that can generate cells of all hematopoietic lineages. These cells do so by balancing an ability to increase their number by proliferation while staying pleuripotent (self-renewal) with their ability to differentiate into any of the hematopoietic lineages. Hematopoietic stem cells also happen to be able to circulate in the systemic circulation, a property likely to be important in their normal function. One of the reasons that we have learned so much about hematopoietic stem cells is that their properties underlie the ability of transplanted bone marrow to populate the marrow of patient recipients with failing bone marrow. Clearly, the regulation of stem cell self-renewal and differentiation is crucial for normal function. A powerful idea that organizes a number of important properties of this regulation is that of the stem cell niche (Ohlstein, Kai, Decotto, et al. 2004; Scadden 2006). A niche is a particular place at which cells and matrix coalesce to regulate stem cells. This concept provides a source of the obvious need for paracrine regulation of stem cell properties. By providing a saturable number of sites for stem cell self-renewal, the niche also suggests a specific regulatory process: stem cells can enter and leave a niche and thus move toward or away from a unique site at which self renewal is possible. A recent series of advances has shown that hematopoietic stem cells can be found adjacent to both osteoblastic cells and endothelial cells in normal bone (Zhang, Niu, Ye, et al. 2003; Kiel, Yilmaz, Iwashita, et al. 2005). Here I will describe how activation of the PTH/PTHrP receptor found on cells of the osteoblast lineage can modify the niche for hematopoietic stem cells in bone in a way that allows such cells to accumulate in the marrow (Calvi, Adams, Weibrecht, et al. 2003). These findings have implications both for the normal regulation of hematopoiesis and for potential therapies in humans needing transplantation of human hematopoietic stem cells.", 
    "editor": [
      {
        "familyName": "Choi", 
        "givenName": "Yongwon", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-0-387-72009-8_7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-0-387-72008-1", 
        "978-0-387-72009-8"
      ], 
      "name": "Osteoimmunology", 
      "type": "Book"
    }, 
    "name": "PTH Regulates the Hematopoietic Stem Cell Niche in Bone", 
    "pagination": "57-60", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17966388"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012101407"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-0-387-72009-8_7"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "39a7e21343b8e2cca623ae35418f852b0015c1e6c9d1cf525a28567d444ef064"
        ]
      }
    ], 
    "publisher": {
      "location": "Boston, MA", 
      "name": "Springer US", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-0-387-72009-8_7", 
      "https://app.dimensions.ai/details/publication/pub.1012101407"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T08:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78965_00000000.jsonl", 
    "type": "Chapter", 
    "url": "https://link.springer.com/10.1007%2F978-0-387-72009-8_7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-72009-8_7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-72009-8_7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-72009-8_7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-72009-8_7'


 

This table displays all metadata directly associated to this object as RDF triples.

132 TRIPLES      23 PREDICATES      46 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-0-387-72009-8_7 schema:about N187ade45fea541a6b11b502532b9835b
2 N6b0d543e02cc4700abcccc9e9cfd1f6f
3 Na61be3ef2941475899a8a778a92f2fa1
4 Ncf948b2bf3c749a791cb106cc2b85a18
5 Neb84c8591da145588f1aaee3b14b38e0
6 Nfe6c2f5ec1a24217a6e2c8204b5f565a
7 anzsrc-for:06
8 anzsrc-for:0601
9 schema:author N9b42fb063aec4b9bbd808eb5273f9bb2
10 schema:citation sg:pub.10.1038/nature02040
11 sg:pub.10.1038/nature02041
12 sg:pub.10.1038/nature04957
13 https://doi.org/10.1016/j.bone.2006.03.002
14 https://doi.org/10.1016/j.ceb.2004.09.003
15 https://doi.org/10.1016/j.cell.2004.07.004
16 https://doi.org/10.1016/j.cell.2005.05.026
17 https://doi.org/10.1016/j.immuni.2004.05.001
18 https://doi.org/10.1056/nejm199609053351004
19 https://doi.org/10.1073/pnas.0508928103
20 https://doi.org/10.1172/jci11296
21 https://doi.org/10.1210/jc.2004-0036
22 schema:datePublished 2007
23 schema:datePublishedReg 2007-01-01
24 schema:description In late fetal life, hematopoiesis moves from the liver to the bone marrow in mammals, and continues to occur throughout postnatal life, with extramedullary hematopoiesis occurring only when disease blocks hematopoiesis in the marrow. Hematopoietic stem cells (HSCs) are uniquely the cells that can generate cells of all hematopoietic lineages. These cells do so by balancing an ability to increase their number by proliferation while staying pleuripotent (self-renewal) with their ability to differentiate into any of the hematopoietic lineages. Hematopoietic stem cells also happen to be able to circulate in the systemic circulation, a property likely to be important in their normal function. One of the reasons that we have learned so much about hematopoietic stem cells is that their properties underlie the ability of transplanted bone marrow to populate the marrow of patient recipients with failing bone marrow. Clearly, the regulation of stem cell self-renewal and differentiation is crucial for normal function. A powerful idea that organizes a number of important properties of this regulation is that of the stem cell niche (Ohlstein, Kai, Decotto, et al. 2004; Scadden 2006). A niche is a particular place at which cells and matrix coalesce to regulate stem cells. This concept provides a source of the obvious need for paracrine regulation of stem cell properties. By providing a saturable number of sites for stem cell self-renewal, the niche also suggests a specific regulatory process: stem cells can enter and leave a niche and thus move toward or away from a unique site at which self renewal is possible. A recent series of advances has shown that hematopoietic stem cells can be found adjacent to both osteoblastic cells and endothelial cells in normal bone (Zhang, Niu, Ye, et al. 2003; Kiel, Yilmaz, Iwashita, et al. 2005). Here I will describe how activation of the PTH/PTHrP receptor found on cells of the osteoblast lineage can modify the niche for hematopoietic stem cells in bone in a way that allows such cells to accumulate in the marrow (Calvi, Adams, Weibrecht, et al. 2003). These findings have implications both for the normal regulation of hematopoiesis and for potential therapies in humans needing transplantation of human hematopoietic stem cells.
25 schema:editor N232ecd95f17c4ff59c749712b0dc38a1
26 schema:genre chapter
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N05fc3723e45f45a490190dcae3dd5f99
30 schema:name PTH Regulates the Hematopoietic Stem Cell Niche in Bone
31 schema:pagination 57-60
32 schema:productId N428c9d33e9154b3e84314cdcd46b28d2
33 N7797a6c367e745659edfe5d21b1dcebc
34 N926cec76038d420fb222823b9ba54b7d
35 Ne9f7e83965dd42f992740ef47beef62f
36 schema:publisher N60d9721ba91e4e908b3ce231f5569bc6
37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012101407
38 https://doi.org/10.1007/978-0-387-72009-8_7
39 schema:sdDatePublished 2019-04-16T08:52
40 schema:sdLicense https://scigraph.springernature.com/explorer/license/
41 schema:sdPublisher N468946d67a8c48819f96cc3429f47efb
42 schema:url https://link.springer.com/10.1007%2F978-0-387-72009-8_7
43 sgo:license sg:explorer/license/
44 sgo:sdDataset chapters
45 rdf:type schema:Chapter
46 N05fc3723e45f45a490190dcae3dd5f99 schema:isbn 978-0-387-72008-1
47 978-0-387-72009-8
48 schema:name Osteoimmunology
49 rdf:type schema:Book
50 N187ade45fea541a6b11b502532b9835b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
51 schema:name Osteoblasts
52 rdf:type schema:DefinedTerm
53 N1901e43e19ea4f7b9dedb6fa6f89f656 schema:familyName Choi
54 schema:givenName Yongwon
55 rdf:type schema:Person
56 N232ecd95f17c4ff59c749712b0dc38a1 rdf:first N1901e43e19ea4f7b9dedb6fa6f89f656
57 rdf:rest rdf:nil
58 N428c9d33e9154b3e84314cdcd46b28d2 schema:name doi
59 schema:value 10.1007/978-0-387-72009-8_7
60 rdf:type schema:PropertyValue
61 N468946d67a8c48819f96cc3429f47efb schema:name Springer Nature - SN SciGraph project
62 rdf:type schema:Organization
63 N60d9721ba91e4e908b3ce231f5569bc6 schema:location Boston, MA
64 schema:name Springer US
65 rdf:type schema:Organisation
66 N6b0d543e02cc4700abcccc9e9cfd1f6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Bone and Bones
68 rdf:type schema:DefinedTerm
69 N7797a6c367e745659edfe5d21b1dcebc schema:name readcube_id
70 schema:value 39a7e21343b8e2cca623ae35418f852b0015c1e6c9d1cf525a28567d444ef064
71 rdf:type schema:PropertyValue
72 N926cec76038d420fb222823b9ba54b7d schema:name pubmed_id
73 schema:value 17966388
74 rdf:type schema:PropertyValue
75 N9b42fb063aec4b9bbd808eb5273f9bb2 rdf:first sg:person.01005031757.00
76 rdf:rest rdf:nil
77 Na61be3ef2941475899a8a778a92f2fa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Animals
79 rdf:type schema:DefinedTerm
80 Ncf948b2bf3c749a791cb106cc2b85a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Parathyroid Hormone
82 rdf:type schema:DefinedTerm
83 Ne9f7e83965dd42f992740ef47beef62f schema:name dimensions_id
84 schema:value pub.1012101407
85 rdf:type schema:PropertyValue
86 Neb84c8591da145588f1aaee3b14b38e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Hematopoietic Stem Cells
88 rdf:type schema:DefinedTerm
89 Nfe6c2f5ec1a24217a6e2c8204b5f565a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Parathyroid Hormone-Related Protein
91 rdf:type schema:DefinedTerm
92 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
93 schema:name Biological Sciences
94 rdf:type schema:DefinedTerm
95 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
96 schema:name Biochemistry and Cell Biology
97 rdf:type schema:DefinedTerm
98 sg:person.01005031757.00 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
99 schema:familyName Kronenberg
100 schema:givenName Henry M
101 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005031757.00
102 rdf:type schema:Person
103 sg:pub.10.1038/nature02040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003509222
104 https://doi.org/10.1038/nature02040
105 rdf:type schema:CreativeWork
106 sg:pub.10.1038/nature02041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033616640
107 https://doi.org/10.1038/nature02041
108 rdf:type schema:CreativeWork
109 sg:pub.10.1038/nature04957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047165782
110 https://doi.org/10.1038/nature04957
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1016/j.bone.2006.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052401014
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1016/j.ceb.2004.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032285616
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1016/j.cell.2004.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033486035
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1016/j.cell.2005.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048721879
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1016/j.immuni.2004.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007621368
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1056/nejm199609053351004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008101955
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1073/pnas.0508928103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049284168
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1172/jci11296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016957718
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1210/jc.2004-0036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287633
129 rdf:type schema:CreativeWork
130 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
131 schema:name Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA.
132 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...