2008
AUTHORS ABSTRACTUnlike cytotoxic drugs, antiangiogenic agents by themselves seldom induce rapid tumor shrinkage over short periods of time. Therefore, traditional clinical endpoints (e.g., complete or partial response) that are used to determine the anti-tumor activity of the former may not necessarily be applicable to the latter. With a myriad of angiogenesis inhibitors undergoing and entering clinical trials for cancer treatment, there is an urgent need to develop and validate novel surrogate biomarkers for defining optimal drug doses and schedules, monitoring drug efficacy, and predicting drug response. This chapter describes the molecular, cellular, and functional imaging candidates currently being explored as potential surrogate pharmacodynamic markers for antiangiogenic therapies. Their advantages and pitfalls are also discussed. More... »
PAGES313-320
Angiogenesis
ISBN
978-0-387-71517-9
978-0-387-71518-6
http://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27'
This table displays all metadata directly associated to this object as RDF triples.
301 TRIPLES
23 PREDICATES
103 URIs
20 LITERALS
8 BLANK NODES