Surrogates for Clinical Development View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Sylvia S. W. Ng , Kim N. Chi

ABSTRACT

Unlike cytotoxic drugs, antiangiogenic agents by themselves seldom induce rapid tumor shrinkage over short periods of time. Therefore, traditional clinical endpoints (e.g., complete or partial response) that are used to determine the anti-tumor activity of the former may not necessarily be applicable to the latter. With a myriad of angiogenesis inhibitors undergoing and entering clinical trials for cancer treatment, there is an urgent need to develop and validate novel surrogate biomarkers for defining optimal drug doses and schedules, monitoring drug efficacy, and predicting drug response. This chapter describes the molecular, cellular, and functional imaging candidates currently being explored as potential surrogate pharmacodynamic markers for antiangiogenic therapies. Their advantages and pitfalls are also discussed. More... »

PAGES

313-320

Book

TITLE

Angiogenesis

ISBN

978-0-387-71517-9
978-0-387-71518-6

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27

DOI

http://dx.doi.org/10.1007/978-0-387-71518-6_27

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001930776


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Departments of Advanced Therapeutics, University of British Columbia, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Sylvia S. W.", 
        "id": "sg:person.012365442052.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012365442052.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Departments of Advanced Therapeutics and Medical Oncology, University of British Columbia, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chi", 
        "givenName": "Kim N.", 
        "id": "sg:person.01142252161.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142252161.65"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ccr.2004.11.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000028656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.11.3658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000159162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mph.0000243657.64056.c3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001670387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mph.0000243657.64056.c3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001670387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.08.140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002368597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdf013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003073567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003700365", 
          "https://doi.org/10.1038/nm988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003700365", 
          "https://doi.org/10.1038/nm988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006231681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008449601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.4801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009392507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-11-4570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010528964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urology.2004.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017185324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017804909", 
          "https://doi.org/10.1038/nrc905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017804909", 
          "https://doi.org/10.1038/nrc905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.26.14608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018416746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019159796", 
          "https://doi.org/10.1038/nrc1369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019159796", 
          "https://doi.org/10.1038/nrc1369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(02)00883-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019974254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-472x(02)00883-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019974254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020541056", 
          "https://doi.org/10.1038/nm1200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020541056", 
          "https://doi.org/10.1038/nm1200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197712)40:6<3107::aid-cncr2820400653>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021195855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdh017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022822335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.02.7458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024759238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.04-3669com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027779591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028029679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.8.4589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030690190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031020150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197111182852108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031952402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2538", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032196257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-08-3210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035760041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci8829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036426384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59259-453-5_18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036606288", 
          "https://doi.org/10.1007/978-1-59259-453-5_18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037538258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000137877.89448.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039040939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000137877.89448.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039040939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mph.0000183863.10792.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039960660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mph.0000183863.10792.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039960660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mph.0000183863.10792.d4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039960660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040662289", 
          "https://doi.org/10.1038/nrc1971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040662289", 
          "https://doi.org/10.1038/nrc1971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041229486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041420286", 
          "https://doi.org/10.1038/sj.bjc.6601035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041420286", 
          "https://doi.org/10.1038/sj.bjc.6601035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-006-9011-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042134066", 
          "https://doi.org/10.1007/s10637-006-9011-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-006-9011-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042134066", 
          "https://doi.org/10.1007/s10637-006-9011-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-006-9011-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042134066", 
          "https://doi.org/10.1007/s10637-006-9011-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa022287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042976289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043834726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdi118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044196097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.12.883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044772253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-3759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045727112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2135406100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050157278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1101-1194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050308225", 
          "https://doi.org/10.1038/nm1101-1194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1101-1194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050308225", 
          "https://doi.org/10.1038/nm1101-1194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-04-1422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051585696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(01)01191-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051682242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051787522", 
          "https://doi.org/10.1038/sj.bjc.6602952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051787522", 
          "https://doi.org/10.1038/sj.bjc.6602952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051910693", 
          "https://doi.org/10.1038/nm1097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051910693", 
          "https://doi.org/10.1038/nm1097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-05-1846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052282298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(91)90391-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052359607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1011141009812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056304954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.1.1992.1.317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059308866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1127592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.05.102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.11.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.05.187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.08.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.08.092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.21.5.1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071514815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-82-1-96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073732684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.4.708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074590088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074595987", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074623639", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074750381", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074829575", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074847514", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074880632", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075070897", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075085502", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075198244", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075221306", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075329243", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077015532", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.23.16_suppl.5000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079369837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082391132", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082707205", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082972417", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347153", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008", 
    "datePublishedReg": "2008-01-01", 
    "description": "Unlike cytotoxic drugs, antiangiogenic agents by themselves seldom induce rapid tumor shrinkage over short periods of time. Therefore, traditional clinical endpoints (e.g., complete or partial response) that are used to determine the anti-tumor activity of the former may not necessarily be applicable to the latter. With a myriad of angiogenesis inhibitors undergoing and entering clinical trials for cancer treatment, there is an urgent need to develop and validate novel surrogate biomarkers for defining optimal drug doses and schedules, monitoring drug efficacy, and predicting drug response. This chapter describes the molecular, cellular, and functional imaging candidates currently being explored as potential surrogate pharmacodynamic markers for antiangiogenic therapies. Their advantages and pitfalls are also discussed.", 
    "editor": [
      {
        "familyName": "Figg", 
        "givenName": "William D.", 
        "type": "Person"
      }, 
      {
        "familyName": "Folkman", 
        "givenName": "Judah", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-0-387-71518-6_27", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-0-387-71517-9", 
        "978-0-387-71518-6"
      ], 
      "name": "Angiogenesis", 
      "type": "Book"
    }, 
    "name": "Surrogates for Clinical Development", 
    "pagination": "313-320", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-0-387-71518-6_27"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "09325b0dce12a78be06af40a1541f7a77afa1475a7ffc0aa9e3ce3347bc30caa"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001930776"
        ]
      }
    ], 
    "publisher": {
      "location": "Boston, MA", 
      "name": "Springer US", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-0-387-71518-6_27", 
      "https://app.dimensions.ai/details/publication/pub.1001930776"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T00:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000244.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-0-387-71518-6_27"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-0-387-71518-6_27'


 

This table displays all metadata directly associated to this object as RDF triples.

301 TRIPLES      23 PREDICATES      103 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-0-387-71518-6_27 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author N92fbe114bf0a43cdb4ba5750b109f272
4 schema:citation sg:pub.10.1007/978-1-59259-453-5_18
5 sg:pub.10.1007/s10637-006-9011-x
6 sg:pub.10.1038/nm1097
7 sg:pub.10.1038/nm1101-1194
8 sg:pub.10.1038/nm1200
9 sg:pub.10.1038/nm988
10 sg:pub.10.1038/nrc1369
11 sg:pub.10.1038/nrc1971
12 sg:pub.10.1038/nrc905
13 sg:pub.10.1038/sj.bjc.6601035
14 sg:pub.10.1038/sj.bjc.6602952
15 https://app.dimensions.ai/details/publication/pub.1074595987
16 https://app.dimensions.ai/details/publication/pub.1074623639
17 https://app.dimensions.ai/details/publication/pub.1074750381
18 https://app.dimensions.ai/details/publication/pub.1074829575
19 https://app.dimensions.ai/details/publication/pub.1074847514
20 https://app.dimensions.ai/details/publication/pub.1074880632
21 https://app.dimensions.ai/details/publication/pub.1075070897
22 https://app.dimensions.ai/details/publication/pub.1075085502
23 https://app.dimensions.ai/details/publication/pub.1075198244
24 https://app.dimensions.ai/details/publication/pub.1075221306
25 https://app.dimensions.ai/details/publication/pub.1075329243
26 https://app.dimensions.ai/details/publication/pub.1077015532
27 https://app.dimensions.ai/details/publication/pub.1082391132
28 https://app.dimensions.ai/details/publication/pub.1082707205
29 https://app.dimensions.ai/details/publication/pub.1082972417
30 https://app.dimensions.ai/details/publication/pub.1083347153
31 https://doi.org/10.1002/1097-0142(197712)40:6<3107::aid-cncr2820400653>3.0.co;2-5
32 https://doi.org/10.1016/0277-5379(91)90391-p
33 https://doi.org/10.1016/j.ccr.2004.11.023
34 https://doi.org/10.1016/j.ccr.2005.08.002
35 https://doi.org/10.1016/j.urology.2004.11.006
36 https://doi.org/10.1016/s0090-4295(01)01191-8
37 https://doi.org/10.1016/s0301-472x(02)00883-4
38 https://doi.org/10.1023/a:1011141009812
39 https://doi.org/10.1056/nejm197111182852108
40 https://doi.org/10.1056/nejmoa022287
41 https://doi.org/10.1056/nejmoa040766
42 https://doi.org/10.1073/pnas.2135406100
43 https://doi.org/10.1073/pnas.95.8.4589
44 https://doi.org/10.1073/pnas.97.26.14608
45 https://doi.org/10.1089/scd.1.1992.1.317
46 https://doi.org/10.1093/annonc/mdf013
47 https://doi.org/10.1093/annonc/mdh017
48 https://doi.org/10.1093/annonc/mdi118
49 https://doi.org/10.1093/jnci/94.12.883
50 https://doi.org/10.1096/fj.04-3669com
51 https://doi.org/10.1097/01.mph.0000183863.10792.d4
52 https://doi.org/10.1097/01.mph.0000243657.64056.c3
53 https://doi.org/10.1126/science.1127592
54 https://doi.org/10.1158/0008-5472.can-04-0580
55 https://doi.org/10.1158/0008-5472.can-05-3759
56 https://doi.org/10.1158/0008-5472.can-05-4411
57 https://doi.org/10.1158/1078-0432.ccr-04-0378
58 https://doi.org/10.1158/1078-0432.ccr-04-2271
59 https://doi.org/10.1158/1078-0432.ccr-04-2538
60 https://doi.org/10.1158/1078-0432.ccr-05-2762
61 https://doi.org/10.1161/01.res.0000137877.89448.78
62 https://doi.org/10.1172/jci8829
63 https://doi.org/10.1182/blood-2004-05-1846
64 https://doi.org/10.1182/blood-2005-04-1422
65 https://doi.org/10.1182/blood-2005-08-3210
66 https://doi.org/10.1182/blood-2005-11-4570
67 https://doi.org/10.1182/blood.v97.11.3658
68 https://doi.org/10.1200/jco.2000.18.4.708
69 https://doi.org/10.1200/jco.2002.05.102
70 https://doi.org/10.1200/jco.2002.11.061
71 https://doi.org/10.1200/jco.2003.05.187
72 https://doi.org/10.1200/jco.2003.08.046
73 https://doi.org/10.1200/jco.2003.08.092
74 https://doi.org/10.1200/jco.2005.02.7458
75 https://doi.org/10.1200/jco.2005.03.4801
76 https://doi.org/10.1200/jco.2005.08.140
77 https://doi.org/10.1200/jco.2005.23.16_suppl.5000
78 https://doi.org/10.3892/ijo.21.5.1111
79 https://doi.org/10.7326/0003-4819-82-1-96
80 schema:datePublished 2008
81 schema:datePublishedReg 2008-01-01
82 schema:description Unlike cytotoxic drugs, antiangiogenic agents by themselves seldom induce rapid tumor shrinkage over short periods of time. Therefore, traditional clinical endpoints (e.g., complete or partial response) that are used to determine the anti-tumor activity of the former may not necessarily be applicable to the latter. With a myriad of angiogenesis inhibitors undergoing and entering clinical trials for cancer treatment, there is an urgent need to develop and validate novel surrogate biomarkers for defining optimal drug doses and schedules, monitoring drug efficacy, and predicting drug response. This chapter describes the molecular, cellular, and functional imaging candidates currently being explored as potential surrogate pharmacodynamic markers for antiangiogenic therapies. Their advantages and pitfalls are also discussed.
83 schema:editor N802a30d30a1e481892b48b87c87b6868
84 schema:genre chapter
85 schema:inLanguage en
86 schema:isAccessibleForFree false
87 schema:isPartOf Nb53f0b80c8ae44c48a19246dce45ea49
88 schema:name Surrogates for Clinical Development
89 schema:pagination 313-320
90 schema:productId N40184219c5344679a8d223b1e553c38f
91 N45d325e04fa3475397640d261c95b58e
92 N9395a2565177441d86eed22b211ad79b
93 schema:publisher Ne37d2af4b90242c58e8bbf41026f450d
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001930776
95 https://doi.org/10.1007/978-0-387-71518-6_27
96 schema:sdDatePublished 2019-04-16T00:46
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N03a8a1c9763143dd847c4420a2056760
99 schema:url http://link.springer.com/10.1007/978-0-387-71518-6_27
100 sgo:license sg:explorer/license/
101 sgo:sdDataset chapters
102 rdf:type schema:Chapter
103 N01ade92beb644b47b50a99b3378e2372 rdf:first N2a312032c4174c629b8db950183baf9c
104 rdf:rest rdf:nil
105 N03a8a1c9763143dd847c4420a2056760 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 N1a6e847d62274a3d9ec03c4834bef042 schema:familyName Figg
108 schema:givenName William D.
109 rdf:type schema:Person
110 N2a312032c4174c629b8db950183baf9c schema:familyName Folkman
111 schema:givenName Judah
112 rdf:type schema:Person
113 N40184219c5344679a8d223b1e553c38f schema:name readcube_id
114 schema:value 09325b0dce12a78be06af40a1541f7a77afa1475a7ffc0aa9e3ce3347bc30caa
115 rdf:type schema:PropertyValue
116 N45d325e04fa3475397640d261c95b58e schema:name doi
117 schema:value 10.1007/978-0-387-71518-6_27
118 rdf:type schema:PropertyValue
119 N802a30d30a1e481892b48b87c87b6868 rdf:first N1a6e847d62274a3d9ec03c4834bef042
120 rdf:rest N01ade92beb644b47b50a99b3378e2372
121 N92fbe114bf0a43cdb4ba5750b109f272 rdf:first sg:person.012365442052.01
122 rdf:rest Na454b39caadf4318984ced26cc62b382
123 N9395a2565177441d86eed22b211ad79b schema:name dimensions_id
124 schema:value pub.1001930776
125 rdf:type schema:PropertyValue
126 Na454b39caadf4318984ced26cc62b382 rdf:first sg:person.01142252161.65
127 rdf:rest rdf:nil
128 Nb53f0b80c8ae44c48a19246dce45ea49 schema:isbn 978-0-387-71517-9
129 978-0-387-71518-6
130 schema:name Angiogenesis
131 rdf:type schema:Book
132 Ne37d2af4b90242c58e8bbf41026f450d schema:location Boston, MA
133 schema:name Springer US
134 rdf:type schema:Organisation
135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
136 schema:name Medical and Health Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
139 schema:name Pharmacology and Pharmaceutical Sciences
140 rdf:type schema:DefinedTerm
141 sg:person.01142252161.65 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
142 schema:familyName Chi
143 schema:givenName Kim N.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142252161.65
145 rdf:type schema:Person
146 sg:person.012365442052.01 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
147 schema:familyName Ng
148 schema:givenName Sylvia S. W.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012365442052.01
150 rdf:type schema:Person
151 sg:pub.10.1007/978-1-59259-453-5_18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036606288
152 https://doi.org/10.1007/978-1-59259-453-5_18
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/s10637-006-9011-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042134066
155 https://doi.org/10.1007/s10637-006-9011-x
156 rdf:type schema:CreativeWork
157 sg:pub.10.1038/nm1097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051910693
158 https://doi.org/10.1038/nm1097
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/nm1101-1194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050308225
161 https://doi.org/10.1038/nm1101-1194
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/nm1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020541056
164 https://doi.org/10.1038/nm1200
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/nm988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003700365
167 https://doi.org/10.1038/nm988
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nrc1369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019159796
170 https://doi.org/10.1038/nrc1369
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/nrc1971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040662289
173 https://doi.org/10.1038/nrc1971
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/nrc905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017804909
176 https://doi.org/10.1038/nrc905
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/sj.bjc.6601035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041420286
179 https://doi.org/10.1038/sj.bjc.6601035
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/sj.bjc.6602952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051787522
182 https://doi.org/10.1038/sj.bjc.6602952
183 rdf:type schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1074595987 schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1074623639 schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1074750381 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1074829575 schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1074847514 schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1074880632 schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1075070897 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1075085502 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1075198244 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1075221306 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1075329243 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1077015532 schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1082391132 schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1082707205 schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1082972417 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1083347153 schema:CreativeWork
200 https://doi.org/10.1002/1097-0142(197712)40:6<3107::aid-cncr2820400653>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021195855
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0277-5379(91)90391-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1052359607
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.ccr.2004.11.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000028656
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.ccr.2005.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043834726
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.urology.2004.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017185324
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s0090-4295(01)01191-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051682242
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0301-472x(02)00883-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019974254
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1023/a:1011141009812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056304954
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1056/nejm197111182852108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031952402
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1056/nejmoa022287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042976289
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1056/nejmoa040766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037538258
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1073/pnas.2135406100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050157278
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1073/pnas.95.8.4589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030690190
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1073/pnas.97.26.14608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018416746
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1089/scd.1.1992.1.317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059308866
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1093/annonc/mdf013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003073567
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1093/annonc/mdh017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022822335
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1093/annonc/mdi118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044196097
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1093/jnci/94.12.883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044772253
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1096/fj.04-3669com schema:sameAs https://app.dimensions.ai/details/publication/pub.1027779591
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1097/01.mph.0000183863.10792.d4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039960660
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/01.mph.0000243657.64056.c3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001670387
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1126/science.1127592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453796
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1158/0008-5472.can-04-0580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041229486
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1158/0008-5472.can-05-3759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045727112
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1158/0008-5472.can-05-4411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006231681
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1158/1078-0432.ccr-04-0378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031020150
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1158/1078-0432.ccr-04-2271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008449601
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1158/1078-0432.ccr-04-2538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032196257
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1158/1078-0432.ccr-05-2762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028029679
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1161/01.res.0000137877.89448.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039040939
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1172/jci8829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036426384
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1182/blood-2004-05-1846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052282298
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1182/blood-2005-04-1422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051585696
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1182/blood-2005-08-3210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035760041
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1182/blood-2005-11-4570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010528964
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1182/blood.v97.11.3658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000159162
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1200/jco.2000.18.4.708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074590088
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1200/jco.2002.05.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202985
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1200/jco.2002.11.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203172
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1200/jco.2003.05.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203635
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1200/jco.2003.08.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203784
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1200/jco.2003.08.092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203798
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1200/jco.2005.02.7458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024759238
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1200/jco.2005.03.4801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009392507
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1200/jco.2005.08.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002368597
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1200/jco.2005.23.16_suppl.5000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079369837
293 rdf:type schema:CreativeWork
294 https://doi.org/10.3892/ijo.21.5.1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071514815
295 rdf:type schema:CreativeWork
296 https://doi.org/10.7326/0003-4819-82-1-96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073732684
297 rdf:type schema:CreativeWork
298 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
299 schema:name Departments of Advanced Therapeutics and Medical Oncology, University of British Columbia, Vancouver, BC, Canada
300 Departments of Advanced Therapeutics, University of British Columbia, Vancouver, BC, Canada
301 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...