Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Karin List , Thomas H. Bugge

ABSTRACT

Recent advances in the mouse and human genome projects have resulted in the identification of a surprisingly large number of genes encoding new proteolytic enzymes which include members of the type II transmembrane serine protease (TTSP) family. In the past few years, the TTSP family has undergone a rapid transformation from a group of largely unexplored proteins into an established family of cell surface-associated proteases playing important roles in development, homeostasis, and pathogenesis. This chapter summarizes current knowledge about the biochemical properties and the biological functions of the TTSP family members in mammalian physiology and disease. More... »

PAGES

259-279

Book

TITLE

The Cancer Degradome

ISBN

978-0-387-69056-8
978-0-387-69057-5

From Grant

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-0-387-69057-5_14

DOI

http://dx.doi.org/10.1007/978-0-387-69057-5_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048143256


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