Second Messenger Systems Involved in Heart Mechanotransduction View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007-01-01

AUTHORS

Hiroshi Hasegawa , Hiroyuki Takano , Yunzeng Zou , Hiroshi Akazawa , Issei Komuro

ABSTRACT

Mechanical stress can be considered one of the major stimuli that evoke hypertrophic responses including reprogramming of gene expression in cardiac myocytes. Therefore, it is important to understand how mechanical loading is sensed by cardiomyocytes and converted into intracellular biomechanical signals leading to cardiac hypertrophy. When mechanical stress is received it is converted also into biochemical signals inside the cells. The signal transduction pathway leading to an increase in protein synthesis is similar to the pathway which is known to be activated by various humoral factors such as growth factors, hormones and cytokines in many other cells. In this review we start with initiation of stress induced signaling and then concentrate on signalling vie MAP-kinase, JAK/STAT and ECM/integrin pathways. Although multiple cellular events which occur in cardiac myocytes in response to mechanical stretch have been clarified, many questions remain unanswered. More... »

PAGES

93-105

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-0-387-48868-4_6

DOI

http://dx.doi.org/10.1007/978-0-387-48868-4_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041680370


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